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Gene Review

MYBBP1A  -  MYB binding protein (P160) 1a

Homo sapiens

Synonyms: FLJ37886, Myb-binding protein 1A, P160, PAP2
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Disease relevance of MYBBP1A


High impact information on MYBBP1A

  • In contrast to the v-abl oncogene product P160, the P210 bcr/abl gene product did not transform NIH/3T3 cells [2].
  • Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL [3].
  • Induction of PAP-2a mRNA was not affected by the protein synthesis inhibitor cycloheximide and was accompanied by a marked increase in PAP-2 activity as measured by the conversion of phosphatidic acid into diacylglycerol in membrane fractions of LNCaP [4].
  • When an octyl glucoside extract of surface-radioiodinated platelets was applied to an affinity matrix of KYGRGDS-coupled Sepharose 4B, a 160-kDa-labeled protein (P160) and GPIIb-IIIa bound and were specifically eluted by soluble GRGDSP peptide, but not by the variant GRGESP peptide [5].
  • Importantly, the phosphotyrosine content of total P160 BCR (induced plus endogenous) was strongly reduced by inducing expression of Bcr, indicating that the induced Bcr protein was not a target of the tyrosine kinase activity of Bcr-Abl but instead functioned as an inhibitor of Bcr-Abl [6].

Biological context of MYBBP1A


Anatomical context of MYBBP1A

  • P210 BCR-ABL is complexed to P160 BCR and ph-P53 proteins in K562 cells [9].
  • Expression levels of MYBBP1a are dependent on the cell type, and are particularly high in Jurkat T cells [8].

Analytical, diagnostic and therapeutic context of MYBBP1A


  1. BCR-ABL tyrosine kinase is autophosphorylated or transphosphorylates P160 BCR on tyrosine predominantly within the first BCR exon. Liu, J., Campbell, M., Guo, J.Q., Lu, D., Xian, Y.M., Andersson, B.S., Arlinghaus, R.B. Oncogene (1993) [Pubmed]
  2. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts. Daley, G.Q., McLaughlin, J., Witte, O.N., Baltimore, D. Science (1987) [Pubmed]
  3. Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL. Lu, D., Liu, J., Campbell, M., Guo, J.Q., Heisterkamp, N., Groffen, J., Canaani, E., Arlinghaus, R. Blood (1993) [Pubmed]
  4. Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP. Ulrix, W., Swinnen, J.V., Heyns, W., Verhoeven, G. J. Biol. Chem. (1998) [Pubmed]
  5. Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. Lam, S.C., Plow, E.F., D'Souza, S.E., Cheresh, D.A., Frelinger, A.L., Ginsberg, M.H. J. Biol. Chem. (1989) [Pubmed]
  6. Bcr: a negative regulator of the Bcr-Abl oncoprotein. Wu, Y., Ma, G., Lu, D., Lin, F., Xu, H.J., Liu, J., Arlinghaus, R.B. Oncogene (1999) [Pubmed]
  7. Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. Keough, R., Woollatt, E., Crawford, J., Sutherland, G.R., Plummer, S., Casey, G., Gonda, T.J. Genomics (1999) [Pubmed]
  8. MYBBP1a is a Novel Repressor of NF-kappaB. Owen, H.R., Elser, M., Cheung, E., Gersbach, M., Kraus, W.L., Hottiger, M.O. J. Mol. Biol. (2007) [Pubmed]
  9. P210 BCR-ABL is complexed to P160 BCR and ph-P53 proteins in K562 cells. Campbell, M.L., Li, W., Arlinghaus, R.B. Oncogene (1990) [Pubmed]
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