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Gene Review

Pepd  -  peptidase D

Mus musculus

Synonyms: Imidodipeptidase, Pep-4, Pep4, Peptidase 4, Peptidase D, ...
 
 
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High impact information on Pepd

 

Biological context of Pepd

  • Analysis of progeny from reciprocal backcrosses established that the electrophoretic forms are expressed codominantly and that Pep-4 is located between the genes for glucosephosphate isomerase (Gpi-1) and pink-eyed dilution (p) on chromosome 7 [3].
  • We cloned mouse prolidase cDNA from a mouse liver cDNA library [4].
 

Associations of Pepd with chemical compounds

  • These results demonstrate that NO stimulates prolidase activity by increasing serine/threonine phosphorylation through PKG-cGMP pathway, but independent of MAPK and suggest an interaction between inflammatory signaling pathways and regulation of the terminal step of matrix degradation [2].
  • To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation [2].
  • Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7 [5].
 

Analytical, diagnostic and therapeutic context of Pepd

  • Northern blot analysis showed that while prolidase mRNA was transcribed in brain, heart, liver, and muscle, it was predominantly transcribed in kidney [4].

References

  1. Genetic factors controlling structure and expression of apolipoproteins B and E in mice. Lusis, A.J., Taylor, B.A., Quon, D., Zollman, S., LeBoeuf, R.C. J. Biol. Chem. (1987) [Pubmed]
  2. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. Surazynski, A., Liu, Y., Miltyk, W., Phang, J.M. J. Cell. Biochem. (2005) [Pubmed]
  3. Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7. Skow, L.C. Biochem. Genet. (1981) [Pubmed]
  4. Cloning of mouse prolidase cDNA: predominant expression of prolidase mRNA in kidney. Ishii, T., Tsujino, S., Matsunobu, S., Endo, F., Sato, K., Sakuragawa, N. Biochim. Biophys. Acta (1996) [Pubmed]
  5. Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7. Lalley, P.A., Francke, U., Minna, J.D. Cytogenet. Cell Genet. (1978) [Pubmed]
 
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