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Gene Review

EEF1G  -  eukaryotic translation elongation factor 1...

Homo sapiens

Synonyms: EF-1-gamma, EF1G, Elongation factor 1-gamma, GIG35, PRO1608, ...
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Disease relevance of EEF1G


High impact information on EEF1G


Biological context of EEF1G


Anatomical context of EEF1G


Associations of EEF1G with chemical compounds


Other interactions of EEF1G

  • GST-like proteins related to class theta comprise a large group including, in addition to typical GSTs and EF1 gamma, stress-induced proteins from bacteria and plants, bacterial reductive dehalogenases and beta-etherases, and several uncharacterized proteins [12].
  • A polyvalent antiserum against EF-1 beta and two monoclonal antibodies against EF-1 gamma were used to identify the protein fragments in this core [13].
  • The affinity of EF-1 alpha for other subunits was as follows, beta beta' gamma > beta beta' > beta not equal to beta'. Likewise, the affinity of EF-1 gamma for other subunits was: beta beta' gamma > beta >> beta'. Phe-tRNA binding activity of the reconstructed EF-1 was about 90% of that of the native EF-1 [14].

Analytical, diagnostic and therapeutic context of EEF1G


  1. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. Lew, Y., Jones, D.V., Mars, W.M., Evans, D., Byrd, D., Frazier, M.L. Pancreas (1992) [Pubmed]
  2. Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon. Chi, K., Jones, D.V., Frazier, M.L. Gastroenterology (1992) [Pubmed]
  3. Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas. Ender, B., Lynch, P., Kim, Y.H., Inamdar, N.V., Cleary, K.R., Frazier, M.L. Mol. Carcinog. (1993) [Pubmed]
  4. The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma. Mimori, K., Mori, M., Tanaka, S., Akiyoshi, T., Sugimachi, K. Cancer (1995) [Pubmed]
  5. Elongation factor 1 gamma mRNA expression in oesophageal carcinoma. Mimori, K., Mori, M., Inoue, H., Ueo, H., Mafune, K., Akiyoshi, T., Sugimachi, K. Gut (1996) [Pubmed]
  6. Nucleotide sequence of a Trypanosoma cruzi cDNA encoding a protein homologous to mammalian EF1 gamma. Billaut-Mulot, O., Pommier, V., Schöneck, R., Plumas-Marty, B., Taibi, A., Loyens, M., Capron, A., Ouaissi, M.A. Nucleic Acids Res. (1993) [Pubmed]
  7. Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. Kumabe, T., Sohma, Y., Yamamoto, T. Nucleic Acids Res. (1992) [Pubmed]
  8. Sequence of a fission yeast gene encoding a protein with extensive homology to eukaryotic elongation factor-1 gamma. Momoi, H., Yamada, H., Ueguchi, C., Mizuno, T. Gene (1993) [Pubmed]
  9. Utility of the nuclear protein-coding gene, elongation factor-1 gamma (EF-1gamma), for spider systematics, emphasizing family level relationships of tarantulas and their kin (Araneae: Mygalomorphae). Ayoub, N.A., Garb, J.E., Hedin, M., Hayashi, C.Y. Mol. Phylogenet. Evol. (2007) [Pubmed]
  10. Isolation and characterization of Leishmania infantum cDNA encoding a protein homologous to eukaryotic elongation factor 1 gamma. Cañavate, C., el Bali, M., Montoya, Y., Barker, D.C., Alvar, J. Trans. R. Soc. Trop. Med. Hyg. (2002) [Pubmed]
  11. A major substrate for MPF: cDNA cloning and expression of polypeptide chain elongation factor 1 gamma from goldfish (Carassius auratus). Tokumoto, M., Nagahama, Y., Tokumoto, T. DNA Seq. (2002) [Pubmed]
  12. Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse, ancient protein superfamily using motif search and structural modeling. Koonin, E.V., Mushegian, A.R., Tatusov, R.L., Altschul, S.F., Bryant, S.H., Bork, P., Valencia, A. Protein Sci. (1994) [Pubmed]
  13. Mapping the functional domains of the eukaryotic elongation factor 1 beta gamma. van Damme, H., Amons, R., Janssen, G., Möller, W. Eur. J. Biochem. (1991) [Pubmed]
  14. Interactions among four subunits of elongation factor 1 from rice embryo. Ejiri, S., Kawamura, R., Katsumata, T. Biochim. Biophys. Acta (1994) [Pubmed]
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