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Gene Review

Cplx1  -  complexin 1

Mus musculus

Synonyms: 921-S, CPX I, Complexin I, Complexin-1, Synaphin-2
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Disease relevance of Cplx1

  • Cplx1-/- mice show pronounced deficits in motor coordination and locomotion including abnormal gait, inability to run or swim, impaired rotarod performance, reduced neuromuscular strength, dystonia and resting tremor [1].

Psychiatry related information on Cplx1


High impact information on Cplx1


Biological context of Cplx1

  • Although the abnormal motor phenotype dominates their overt symptoms, Cplx1-/- mice also show other behavioural deficits, particularly in complex behaviours [1].
  • Complexin binds selectively to the neuronal SNARE complex, but how this promotes exocytosis remains unknown [4].
  • Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity [6].
  • Surface biotinylation demonstrated that the complexin-induced reduction in basal I(sc)was due to a reduction in apical membrane-resident ENaC and the inhibition in forskolin stimulation was due to the lack of ENaC insertion into the apical membrane to increase surface channel number [7].
  • The long-term potentiation (LTP) by high-frequency stimulation, recorded in the hippocampal CA1 area, was decreased in complexin II-lacking mice (CPXII KO mice) [8].

Anatomical context of Cplx1


Physical interactions of Cplx1

  • Here we used purified full-length and truncated SNARE proteins and a gel shift assay to show that the action of complexin on SNARE complex depends strictly on the transmembrane regions of syntaxin and synaptobrevin [4].

Other interactions of Cplx1


  1. Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits. Glynn, D., Drew, C.J., Reim, K., Brose, N., Morton, A.J. Hum. Mol. Genet. (2005) [Pubmed]
  2. A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse. Gibson, H.E., Reim, K., Brose, N., Morton, A.J., Jones, S. Eur. J. Neurosci. (2005) [Pubmed]
  3. Vulnerability of synaptic plasticity in the complexin II knockout mouse to maternal deprivation stress. Yamauchi, Y., Qin, L.H., Nishihara, M., Sawada, K., Kato, K., Inoue, S. Brain Res. (2005) [Pubmed]
  4. Action of complexin on SNARE complex. Hu, K., Carroll, J., Rickman, C., Davletov, B. J. Biol. Chem. (2002) [Pubmed]
  5. Complexin I regulates glucose-induced secretion in pancreatic beta-cells. Abderrahmani, A., Niederhauser, G., Plaisance, V., Roehrich, M.E., Lenain, V., Coppola, T., Regazzi, R., Waeber, G. J. Cell. Sci. (2004) [Pubmed]
  6. Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses. Takahashi, S., Yamamoto, H., Matsuda, Z., Ogawa, M., Yagyu, K., Taniguchi, T., Miyata, T., Kaba, H., Higuchi, T., Okutani, F. FEBS Lett. (1995) [Pubmed]
  7. PKA-dependent ENaC trafficking requires the SNARE-binding protein complexin. Butterworth, M.B., Frizzell, R.A., Johnson, J.P., Peters, K.W., Edinger, R.S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  8. Involvement of complexin II in synaptic plasticity in the CA1 region of the hippocampus: the use of complexin II-lacking mice. Huang, G.Z., Ujihara, H., Takahashi, S., Kaba, H., Yagi, T., Inoue, S. Jpn. J. Pharmacol. (2000) [Pubmed]
  9. Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease. Morton, A.J., Edwardson, J.M. J. Neurochem. (2001) [Pubmed]
  10. Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I. Schaub, J.R., Lu, X., Doneske, B., Shin, Y.K., McNew, J.A. Nat. Struct. Mol. Biol. (2006) [Pubmed]
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