The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tnfsf8  -  tumor necrosis factor (ligand) superfamily...

Mus musculus

Synonyms: CD153, CD30 ligand, CD30-L, CD30LG, Cd30L, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tnfsf8


High impact information on Tnfsf8

  • Unlike dendritic cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand [4].
  • Importantly, neither suppression of allograft rejection nor enhanced apoptosis of memory CD8(+) T cells was observed when Treg cells lacked CD30 or when CD30 ligand-CD30 interaction was blocked with anti-CD30 ligand Ab [5].
  • Combination of NPM-ALK repression and CD30 ligand leads to significantly increased tumor cell growth inhibition compared with one method alone, suggesting its potential application for ALCL-specific cancer treatment [6].
  • A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells [7].
  • Immobilized, but not soluble, forms of anti-CD30 Abs (HRS-4 and Ber-H8) or recombinant mouse CD30 ligand exhibited an extremely rapid and intense survival-reducing effect on the eosinophils in the presence of exogenous IL-5; this effect was both concentration and time dependent [8].

Biological context of Tnfsf8


Anatomical context of Tnfsf8


Regulatory relationships of Tnfsf8

  • Anti-CD30L and anti-4-1BBL MAbs stimulated IL-6 production by cardiac myocytes in vitro [12].
  • The pleiotropic functions of CD30 are initiated by interaction of CD30-expressing cells with other immune competent cells expressing CD30-L and providing the signals for modulation of effector cell activity [13].

Other interactions of Tnfsf8

  • Thirdly, the effects of in vivo administration of anti-CD30L, anti-CD27L, anti-OX40L, or anti-4-1BBL MAb on the development of acute viral myocarditis were examined [12].

Analytical, diagnostic and therapeutic context of Tnfsf8

  • In addition, the treatment with anti-CD30L mAb also inhibited the development of diabetes induced by adoptive transfer of spleen cells from diabetic NOD mice or islet-specific CD4+ or CD8+ T cell lines into NOD-SCID mice [2].


  1. Expression of tumour necrosis factor (TNF) receptor/ligand superfamily co-stimulatory molecules CD40, CD30L, CD27L, and OX40L in murine hearts with chronic ongoing myocarditis caused by coxsackie virus B3. Seko, Y., Takahashi, N., Oshima, H., Shimozato, O., Akiba, H., Kobata, T., Yagita, H., Okumura, K., Azuma, M., Yazaki, Y. J. Pathol. (1999) [Pubmed]
  2. Critical roles of CD30/CD30L interactions in murine autoimmune diabetes. Chakrabarty, S., Nagata, M., Yasuda, H., Wen, L., Nakayama, M., Chowdhury, S.A., Yamada, K., Jin, Z., Kotani, R., Moriyama, H., Shimozato, O., Yagita, H., Yokono, K. Clin. Exp. Immunol. (2003) [Pubmed]
  3. ADAM10 Inhibition of Human CD30 Shedding Increases Specificity of Targeted Immunotherapy In vitro. Eichenauer, D.A., Simhadri, V.L., von Strandmann, E.P., Ludwig, A., Matthews, V., Reiners, K.S., von Tresckow, B., Saftig, P., Rose-John, S., Engert, A., Hansen, H.P. Cancer Res. (2007) [Pubmed]
  4. CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Kim, M.Y., Gaspal, F.M., Wiggett, H.E., McConnell, F.M., Gulbranson-Judge, A., Raykundalia, C., Walker, L.S., Goodall, M.D., Lane, P.J. Immunity (2003) [Pubmed]
  5. CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism. Dai, Z., Li, Q., Wang, Y., Gao, G., Diggs, L.S., Tellides, G., Lakkis, F.G. J. Clin. Invest. (2004) [Pubmed]
  6. The Expression of CD30 in Anaplastic Large Cell Lymphoma Is Regulated by Nucleophosmin-Anaplastic Lymphoma Kinase-Mediated JunB Level in a Cell Type-Specific Manner. Hsu, F.Y., Johnston, P.B., Burke, K.A., Zhao, Y. Cancer Res. (2006) [Pubmed]
  7. A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. Nishimura, H., Yajima, T., Muta, H., Podack, E.R., Tani, K., Yoshikai, Y. J. Immunol. (2005) [Pubmed]
  8. Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. Matsumoto, K., Terakawa, M., Miura, K., Fukuda, S., Nakajima, T., Saito, H. J. Immunol. (2004) [Pubmed]
  9. Deciphering CD30 ligand biology and its role in humoral immunity. Kennedy, M.K., Willis, C.R., Armitage, R.J. Immunology (2006) [Pubmed]
  10. Regulation of murine B cell growth and differentiation by CD30 ligand. Shanebeck, K.D., Maliszewski, C.R., Kennedy, M.K., Picha, K.S., Smith, C.A., Goodwin, R.G., Grabstein, K.H. Eur. J. Immunol. (1995) [Pubmed]
  11. Shedding of the soluble form of CD30 from the Hodgkin-analogous cell line L540 is strongly inhibited by a new CD30-specific antibody (Ki-4). Horn-Lohrens, O., Tiemann, M., Lange, H., Kobarg, J., Hafner, M., Hansen, H., Sterry, W., Parwaresch, R.M., Lemke, H. Int. J. Cancer (1995) [Pubmed]
  12. Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3. Seko, Y., Takahashi, N., Oshima, H., Shimozato, O., Akiba, H., Takeda, K., Kobata, T., Yagita, H., Okumura, K., Azuma, M., Nagai, R. J. Pathol. (2001) [Pubmed]
  13. Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation. Nam, S.Y., Cho, K.S., Heo, Y.M., Ha, J.C., Kim, Y.H., Keun Yi, H., Han Hwang, P., Kim, H.M., Podack, E.R. Cell. Immunol. (2002) [Pubmed]
WikiGenes - Universities