Gene Review:
Tnfsf4 - tumor necrosis factor (ligand) superfamily...
Mus musculus
Synonyms:
Ath-1, Ath1, CD134L, OX-40L, OX40 ligand, ...
Phelan,
Beier,
Higgins,
Paigen,
Obermeier,
Schwarz,
Dunger,
Strauch,
Grunwald,
Schölmerich,
Falk,
Wang,
Ria,
Kelmenson,
Eriksson,
Higgins,
Samnegård,
Petros,
Rollins,
Bennet,
Wiman,
de Faire,
Wennberg,
Olsson,
Ishii,
Sugamura,
Hamsten,
Forsman-Semb,
Lagercrantz,
Paigen,
Prina,
Abdi,
Lebastard,
Perret,
Winter,
Antoine,
Seko,
Takahashi,
Oshima,
Shimozato,
Akiba,
Takeda,
Kobata,
Yagita,
Okumura,
Azuma,
Nagai,
- Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. Akiba, H., Miyahira, Y., Atsuta, M., Takeda, K., Nohara, C., Futagawa, T., Matsuda, H., Aoki, T., Yagita, H., Okumura, K. J. Exp. Med. (2000)
- OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Humphreys, I.R., Edwards, L., Walzl, G., Rae, A.J., Dougan, G., Hill, S., Hussell, T. J. Immunol. (2003)
- Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. Martin-Orozco, N., Chen, Z., Poirot, L., Hyatt, E., Chen, A., Kanagawa, O., Sharpe, A., Mathis, D., Benoist, C. J. Immunol. (2003)
- Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3. Seko, Y., Takahashi, N., Oshima, H., Shimozato, O., Akiba, H., Takeda, K., Kobata, T., Yagita, H., Okumura, K., Azuma, M., Nagai, R. J. Pathol. (2001)
- Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Sato, T., Ishii, N., Murata, K., Kikuchi, K., Nakagawa, S., Ndhlovu, L.C., Sugamura, K. Eur. J. Immunol. (2002)
- Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Wang, X., Ria, M., Kelmenson, P.M., Eriksson, P., Higgins, D.C., Samnegård, A., Petros, C., Rollins, J., Bennet, A.M., Wiman, B., de Faire, U., Wennberg, C., Olsson, P.G., Ishii, N., Sugamura, K., Hamsten, A., Forsman-Semb, K., Lagercrantz, J., Paigen, B. Nat. Genet. (2005)
- CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells. Kim, M.Y., Gaspal, F.M., Wiggett, H.E., McConnell, F.M., Gulbranson-Judge, A., Raykundalia, C., Walker, L.S., Goodall, M.D., Lane, P.J. Immunity (2003)
- Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Chen, A.I., McAdam, A.J., Buhlmann, J.E., Scott, S., Lupher, M.L., Greenfield, E.A., Baum, P.R., Fanslow, W.C., Calderhead, D.M., Freeman, G.J., Sharpe, A.H. Immunity (1999)
- Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Stüber, E., Neurath, M., Calderhead, D., Fell, H.P., Strober, W. Immunity (1995)
- OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice. Obermeier, F., Schwarz, H., Dunger, N., Strauch, U.G., Grunwald, N., Schölmerich, J., Falk, W. Eur. J. Immunol. (2003)
- A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. Kleijnen, M.F., Huppa, J.B., Lucin, P., Mukherjee, S., Farrell, H., Campbell, A.E., Koszinowski, U.H., Hill, A.B., Ploegh, H.L. EMBO J. (1997)
- Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Paigen, B., Mitchell, D., Reue, K., Morrow, A., Lusis, A.J., LeBoeuf, R.C. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. Al-Shamkhani, A., Mallett, S., Brown, M.H., James, W., Barclay, A.N. J. Biol. Chem. (1997)
- Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. Murata, K., Nose, M., Ndhlovu, L.C., Sato, T., Sugamura, K., Ishii, N. J. Immunol. (2002)
- Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. Takeda, I., Ine, S., Killeen, N., Ndhlovu, L.C., Murata, K., Satomi, S., Sugamura, K., Ishii, N. J. Immunol. (2004)
- Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L.C., Nose, M., Noda, T., Sugamura, K. J. Exp. Med. (2000)
- The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. Stüber, E., Strober, W. J. Exp. Med. (1996)
- The murine cytomegalovirus immune evasion protein m4/gp34 forms biochemically distinct complexes with class I MHC at the cell surface and in a pre-Golgi compartment. Kavanagh, D.G., Koszinowski, U.H., Hill, A.B. J. Immunol. (2001)
- OX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expression. Kim, M.Y., Anderson, G., White, A., Jenkinson, E., Arlt, W., Martensson, I.L., Erlandsson, L., Lane, P.J. J. Immunol. (2005)
- Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation. Prina, E., Abdi, S.Z., Lebastard, M., Perret, E., Winter, N., Antoine, J.C. J. Cell. Sci. (2004)
- 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. Dawicki, W., Bertram, E.M., Sharpe, A.H., Watts, T.H. J. Immunol. (2004)
- Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. Linton, P.J., Bautista, B., Biederman, E., Bradley, E.S., Harbertson, J., Kondrack, R.M., Padrick, R.C., Bradley, L.M. J. Exp. Med. (2003)
- Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. Gramaglia, I., Weinberg, A.D., Lemon, M., Croft, M. J. Immunol. (1998)
- OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors. Kim, M.Y., Bekiaris, V., McConnell, F.M., Gaspal, F.M., Raykundalia, C., Lane, P.J. J. Immunol. (2005)
- The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. Ekkens, M.J., Liu, Z., Liu, Q., Whitmire, J., Xiao, S., Foster, A., Pesce, J., VanNoy, J., Sharpe, A.H., Urban, J.F., Gause, W.C. J. Immunol. (2003)
- During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion. Hendriks, J., Xiao, Y., Rossen, J.W., van der Sluijs, K.F., Sugamura, K., Ishii, N., Borst, J. J. Immunol. (2005)
- Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Wang, X., Phelan, S.A., Petros, C., Taylor, E.F., Ledinski, G., Jürgens, G., Forsman-Semb, K., Paigen, B. Atherosclerosis (2004)
- Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1. Phelan, S.A., Beier, D.R., Higgins, D.C., Paigen, B. Mamm. Genome (2002)
- Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Totsuka, T., Kanai, T., Uraushihara, K., Iiyama, R., Yamazaki, M., Akiba, H., Yagita, H., Okumura, K., Watanabe, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. Andarini, S., Kikuchi, T., Nukiwa, M., Pradono, P., Suzuki, T., Ohkouchi, S., Inoue, A., Maemondo, M., Ishii, N., Saijo, Y., Sugamura, K., Nukiwa, T. Cancer Res. (2004)
- OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response. Gri, G., Gallo, E., Di Carlo, E., Musiani, P., Colombo, M.P. J. Immunol. (2003)