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Gene Review

ADNP  -  activity-dependent neuroprotector homeobox

Homo sapiens

Synonyms: ADNP1, Activity-dependent neuroprotective protein, Activity-dependent neuroprotector homeobox protein, KIAA0784, MRD28
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Disease relevance of ADNP

  • When incubated with pheochromocytoma (PC12) cells, a neuronal model, VP22-ADNP was associated with the cells after a 25-min incubation period [1].
  • Pre-incubation with VP22-ADNP enriched protein fractions protected against beta amyloid peptide toxicity and oxidative stress (H2O2) in PC12 cells [1].
  • The hADNP gene was mapped to chromosome 20q12-13.2, a region associated with aggressive tumor growth, frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. hADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells [2].

High impact information on ADNP


Biological context of ADNP

  • ADNP, a potential mediator of VIP-associated neuronal survival, and the new peptide, a potential lead compound for drug design, are discussed below [5].

Anatomical context of ADNP


Analytical, diagnostic and therapeutic context of ADNP

  • When the VIP paralog, PACAP38 was added to mouse neuron-glia co-cultures, it induced ADNP mRNA expression in a bimodal fashion at subpico- and nanomolar concentrations with greater response at subpicomolar level [4].


  1. Recombinant activity-dependent neuroprotective protein protects cells against oxidative stress. Steingart, R.A., Gozes, I. Mol. Cell. Endocrinol. (2006) [Pubmed]
  2. Cloning and characterization of the human activity-dependent neuroprotective protein. Zamostiano, R., Pinhasov, A., Gelber, E., Steingart, R.A., Seroussi, E., Giladi, E., Bassan, M., Wollman, Y., Eyre, H.J., Mulley, J.C., Brenneman, D.E., Gozes, I. J. Biol. Chem. (2001) [Pubmed]
  3. Brain deficits associated with fetal alcohol exposure may be protected, in part, by peptides derived from activity-dependent neurotrophic factor and activity-dependent neuroprotective protein. Sari, Y., Gozes, I. Brain Res. Brain Res. Rev. (2006) [Pubmed]
  4. Signaling involved in pituitary adenylate cyclase-activating polypeptide-stimulated ADNP expression. Nakamachi, T., Li, M., Shioda, S., Arimura, A. Peptides (2006) [Pubmed]
  5. A novel signaling molecule for neuropeptide action: activity-dependent neuroprotective protein. Gozes, I., Bassan, M., Zamostiano, R., Pinhasov, A., Davidson, A., Giladi, E., Perl, O., Glazner, G.W., Brenneman, D.E. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  6. Neurotrophic effects of the peptide NAP: a novel neuroprotective drug candidate. Gozes, I., Spivak-Pohis, I. Current Alzheimer research. (2006) [Pubmed]
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