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Gene Review

ZFPM2  -  zinc finger protein, FOG family member 2

Homo sapiens

Synonyms: DIH3, FOG-2, FOG2, Friend of GATA 2, Friend of GATA protein 2, ...
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Disease relevance of ZFPM2


High impact information on ZFPM2


Biological context of ZFPM2


Anatomical context of ZFPM2

  • The hFOG-2 gene was initially detected in K562 cells using a polymerase chain reaction approach with degenerate primers corresponding to zinc finger regions of mFOG-1 [7].
  • Taken together with GATA4's known role in promoting EMT, these results suggest that FOG-2 functions in cardiac valve formation as an attenuator of EMT by repressing GATA4 activity within the developing endocardial cushions [8].
  • In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with the expression of MIS [9].

Other interactions of ZFPM2

  • Therefore, we screened 40 individuals affected by nonsyndromic TriAt for ZFPM2/FOG2 and HEY2 gene mutations [3].

Analytical, diagnostic and therapeutic context of ZFPM2


  1. AML1-FOG2 fusion protein in myelodysplasia. Chan, E.M., Comer, E.M., Brown, F.C., Richkind, K.E., Holmes, M.L., Chong, B.H., Shiffman, R., Zhang, D.E., Slovak, M.L., Willman, C.L., Noguchi, C.T., Li, Y., Heiber, D.J., Kwan, L., Chan, R.J., Vance, G.H., Ramsey, H.C., Hromas, R.A. Blood (2005) [Pubmed]
  2. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. Pizzuti, A., Sarkozy, A., Newton, A.L., Conti, E., Flex, E., Digilio, M.C., Amati, F., Gianni, D., Tandoi, C., Marino, B., Crossley, M., Dallapiccola, B. Hum. Mutat. (2003) [Pubmed]
  3. ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. Sarkozy, A., Conti, E., D'Agostino, R., Digilio, M.C., Formigari, R., Picchio, F., Marino, B., Pizzuti, A., Dallapiccola, B. Am. J. Med. Genet. A (2005) [Pubmed]
  4. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Svensson, E.C., Tufts, R.L., Polk, C.E., Leiden, J.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. Lin, A.C., Roche, A.E., Wilk, J., Svensson, E.C. J. Biol. Chem. (2004) [Pubmed]
  6. A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot. Nemer, G., Fadlalah, F., Usta, J., Nemer, M., Dbaibo, G., Obeid, M., Bitar, F. Hum. Mutat. (2006) [Pubmed]
  7. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. Holmes, M., Turner, J., Fox, A., Chisholm, O., Crossley, M., Chong, B. J. Biol. Chem. (1999) [Pubmed]
  8. FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Flagg, A.E., Earley, J.U., Svensson, E.C. Dev. Biol. (2007) [Pubmed]
  9. FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Anttonen, M., Ketola, I., Parviainen, H., Pusa, A.K., Heikinheimo, M. Biol. Reprod. (2003) [Pubmed]
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