High impact information on Acr

• Calculations of the rates of inactivation of memsin by peptidyl-chloromethanes and comparison with rate constants obtained with other serine proteinases indicated that memsin closely resembled trypsin and acrosin [1].
• As expected, acrosomes and proacrosomal vesicles in the trans-Golgi region contained abundant acrosin [2].
• We studied the biogenesis of the acrosome in sperm cells in immunogold-labeled ultrathin cryosections of rat testis, using a variety of antibodies against endosomal/lysosomal marker protein and acrosin, the major secretory protein of sperm cells [2].
• Biosynthesis of acrosin was found to start in early round spermatids which are haploid germ cells [3].
• Diploid expression and translational regulation of rat acrosin gene [3].

Biological context of Acr

• Using the indirect immunofluorescence staining technique, the developmental pattern of acrosin during spermatogenesis of boar, ram, rabbit, mouse, rat, and Russian hamster (Phodopus sungorus) was studied [4].

Anatomical context of Acr

• Acrosin, a sperm acrosomal serine protease has been implicated in the recognition, binding and penetration of the zona pellucida of the ovum [3].
• The findings suggest that the enzymatically inactive high molecular weight component (proacrosin) present in the caput spermatozoa is partially converted to the low molecular weight components (acrosin) during epididymal transit [5].

Associations of Acr with chemical compounds

• The sensitivity of these molecular forms to an inhibitor of acrosin, p-nitrophenyl p'-guanidino benzoate (NPGB), and the fact that all four forms cross-reacted with the antibody against guinea pig testis proacrosin, suggest that these molecular forms are proacrosin-acrosin components [5].
• Extrapolating the data of the two co-extracted acrosomal proteases, the ratio of acrosin-like protease [E] and benzamidine-resistant protease [E]x, it was possible to correlate the value expressed to the rate of pregnancy [6].

Other interactions of Acr

• Functional domains like the catalytic triad (His-70, Asp-124, Ser-222) are highly conserved not only between the available acrosin primary structures of different mammals but also in comparison with other serine proteinases [7].

Analytical, diagnostic and therapeutic context of Acr

• An intravaginal contraceptive device for the delivery of an acrosin and hyaluronidase inhibitor [8].
• Intraperitoneal injections of extracts of Spartium junceum in adult male rats were shown to reduce the rate of fertility and acrosin enzyme activity [6].

References