Gene Review:
Atxn7 - ataxin 7
Mus musculus
Synonyms:
A430107N12Rik, AI627028, Ataxin-7, Sca7, Spinocerebellar ataxia type 7 protein homolog, ...
- Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization. Chen, S., Peng, G.H., Wang, X., Smith, A.C., Grote, S.K., Sopher, B.L., La Spada, A.R. Hum. Mol. Genet. (2004)
- SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Yoo, S.Y., Pennesi, M.E., Weeber, E.J., Xu, B., Atkinson, R., Chen, S., Armstrong, D.L., Wu, S.M., Sweatt, J.D., Zoghbi, H.Y. Neuron (2003)
- Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. La Spada, A.R., Fu, Y.H., Sopher, B.L., Libby, R.T., Wang, X., Li, L.Y., Einum, D.D., Huang, J., Possin, D.E., Smith, A.C., Martinez, R.A., Koszdin, K.L., Treuting, P.M., Ware, C.B., Hurley, J.B., Ptácek, L.J., Chen, S. Neuron (2001)
- PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. Janer, A., Martin, E., Muriel, M.P., Latouche, M., Fujigasaki, H., Ruberg, M., Brice, A., Trottier, Y., Sittler, A. J. Cell Biol. (2006)
- Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene. Ström, A.L., Jonasson, J., Hart, P., Brännström, T., Forsgren, L., Holmberg, M. Gene (2002)
- Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice. Garden, G.A., Libby, R.T., Fu, Y.H., Kinoshita, Y., Huang, J., Possin, D.E., Smith, A.C., Martinez, R.A., Fine, G.C., Grote, S.K., Ware, C.B., Einum, D.D., Morrison, R.S., Ptacek, L.J., Sopher, B.L., La Spada, A.R. J. Neurosci. (2002)
- Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model. Helmlinger, D., Abou-Sleymane, G., Yvert, G., Rousseau, S., Weber, C., Trottier, Y., Mandel, J.L., Devys, D. J. Neurosci. (2004)
- Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Yvert, G., Lindenberg, K.S., Picaud, S., Landwehrmeyer, G.B., Sahel, J.A., Mandel, J.L. Hum. Mol. Genet. (2000)
- Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. Helmlinger, D., Hardy, S., Abou-Sleymane, G., Eberlin, A., Bowman, A.B., Gansmüller, A., Picaud, S., Zoghbi, H.Y., Trottier, Y., Tora, L., Devys, D. PLoS Biol. (2006)
- Identification and characterization of Spinocerebellar Ataxia Type 7 (SCA7) isoform SCA7b in mice. Ström, A.L., Forsgren, L., Holmberg, M. Biochim. Biophys. Acta (2005)