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Gene Review

Mapk10  -  mitogen activated protein kinase 10

Rattus norvegicus

Synonyms: Jnk3, MAP kinase 10, MAPK 10, Mitogen-activated protein kinase 10, Prkm10, ...
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High impact information on Mapk10


Biological context of Mapk10


Anatomical context of Mapk10

  • c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10 [4].
  • The present study examined the stressor-like effects of repeated (4 days) administration of cocaine hydrochloride(COC) (35 mg/kg, i.p.) on the expression of heat shock proteins (HSPs) (HSP27, HSP60, HSP70, HSC70) and stress-activated protein kinases (SAPKs) (SAPKalpha, SAPKbeta, SAPKgamma) in the rat hippocampus [5].
  • Similar to the effects of a 10 min immobilization stress (IM) over 4 days, an early increase (5 h time point) in nerve cells immunoreactive for HSPs (HSP27, HSP60, HSP70, HSC70) and SAPKs (SAPKbeta, SAPKgamma) was observed in the COC group [5].

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