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Gene Review:

Mapk10 - mitogen activated protein kinase 10

Rattus norvegicus

Synonyms: Jnk3, MAP kinase 10, MAPK 10, Mitogen-activated protein kinase 10, Prkm10, ...

Hayase, T. et al., Fan, X.L. et al., Malek, R.L. et al., Neidhart, S. et al., Guan, Z. et al., et al.

Meeker, Fernandes, Hayase, Yamamoto, Yamamoto, Muso, Shiota,

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High impact information on Mapk10

Inhibiting ERK1/ERK2 with PD98059 or inhibiting SAPK/JNK by transfecting cells with a dominant-negative SAPKbeta/JNK3 mutant partially blocked NGF-induced down-regulation of A(2A)AR expression in PC12 cells [1].
Treating SAPKbeta/JNK3 mutant-transfected PC12 cells with PD98059 completely abolished the NGF-induced decrease in A(2A)AR mRNA and protein levels [1].
The current study demonstrates that overexpression of the dominant negative form of JNK1 or p54 JNK2/SAPKbeta reduces Cox-2 expression and PGE2 production stimulated by IL-1beta [2].
It has been demonstrated that opioid drugs are capable to induce apoptosis of neuronal cells, but the mechanism is not clear. c-Jun N-terminal kinase 3 (JNK3), specifically expressed in brain, has been proved to mediate neuronal apoptosis and is involved in opiate-induced cell apoptosis in vitro [3].
Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain [3].

Biological context of Mapk10

JNK3/SAPKbeta phosphorylation occurs at Ser-62 and Ser-73, residues that result in reduced microtubule-destabilizing activity for SCG10 [4].

Anatomical context of Mapk10

c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10 [4].
The present study examined the stressor-like effects of repeated (4 days) administration of cocaine hydrochloride(COC) (35 mg/kg, i.p.) on the expression of heat shock proteins (HSPs) (HSP27, HSP60, HSP70, HSC70) and stress-activated protein kinases (SAPKs) (SAPKalpha, SAPKbeta, SAPKgamma) in the rat hippocampus [5].
Similar to the effects of a 10 min immobilization stress (IM) over 4 days, an early increase (5 h time point) in nerve cells immunoreactive for HSPs (HSP27, HSP60, HSP70, HSC70) and SAPKs (SAPKbeta, SAPKgamma) was observed in the COC group [5].

Other interactions of Mapk10

Low basal expression of JNK-2 (SAPK-alpha) and JNK-3 (SAPK-beta) was seen in vivo and in vitro [6].

References

Adenosine A(2A) receptor mRNA regulation by nerve growth factor is TrkA-, Src-, and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH(2)-terminal kinase. Malek, R.L., Nie, Z., Ramkumar, V., Lee, N.H. J. Biol. Chem. (1999) [Pubmed]
Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan, Z., Buckman, S.Y., Miller, B.W., Springer, L.D., Morrison, A.R. J. Biol. Chem. (1998) [Pubmed]
Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain. Fan, X.L., Zhang, J.S., Zhang, X.Q., Ma, L. Neuroscience (2003) [Pubmed]
c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10. Neidhart, S., Antonsson, B., Gilliéron, C., Vilbois, F., Grenningloh, G., Arkinstall, S. FEBS Lett. (2001) [Pubmed]
Stressor-like effects of cocaine on heat shock protein and stress-activated protein kinase expression in the rat hippocampus: interaction with ethanol and anti-toxicity drugs. Hayase, T., Yamamoto, Y., Yamamoto, K., Muso, E., Shiota, K. Legal medicine (Tokyo, Japan) (2003) [Pubmed]
Osmotic and glutamate receptor regulation of c-Jun NH(2)-terminal protein kinase in neuroendocrine cells. Meeker, R., Fernandes, A. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]

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