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Gene Review

Mapk10  -  mitogen-activated protein kinase 10

Mus musculus

Synonyms: C230008H04Rik, JNK3, JNK3B1, JNK3B2, Jnk3, ...
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Disease relevance of Mapk10


High impact information on Mapk10

  • Mice lacking individual members of the Jnk family (Jnk1, Jnk2, and Jnk3) are viable and survive without overt structural abnormalities [3].
  • We found that syd and JNK3 are present on vesicular structures in axons, are transported in both the anterograde and retrograde axonal transport pathways, and interact with kinesin-I and the dynactin complex [4].
  • Our data revealed that JNK2- and JNK3-induced COX-2 may be a principle pathway responsible for neurodegeneration in PD [5].
  • A critical role of neural-specific JNK3 for ischemic apoptosis [1].
  • Neural differentiation was observed in wild-type, JNK2(-/-), and JNK3(-/-) cultures but not in JNK1(-/-) EBs [6].

Biological context of Mapk10


Anatomical context of Mapk10

  • Therefore, we have investigated the contractility of blood vessels in mice with genetically deleted JNK1, JNK2, JNK3 and JNK2+3 isoforms and their respective wildtypes [9].
  • Following transection of the medial forebrain bundle, however, JNK3 ko conferred persisting neuroprotection of axotomised SNC neurons [2].
  • Survival of dopaminergic neurons in the substantia nigra compacta (SNC) following intrastriatal injection of 6-hydroxydopamine was transiently improved in JNK3 ko and c-JunAA mice after 7 days, but not 60 days [2].
  • Robust interaction of free arrestins with JNK3 and Mdm2 and their ability to regulate subcellular localization of these proteins may play an important role in the survival of photoreceptors and other neurons, as well as in retinal and neuronal degeneration [10].

Associations of Mapk10 with chemical compounds


Other interactions of Mapk10

  • We conclude that endogenous AICD undergoes tight temporal regulation during the differentiation of neurons and is negatively regulated by JNK3 via phosphorylation of APP at Thr668 [13].

Analytical, diagnostic and therapeutic context of Mapk10

  • In a sciatic axotomy model of neuronal injury in the neonate, death of DRG neurons was also reduced by JNK3 deficiency [7].
  • SAPKbeta/JNK3 is present at levels that are 1/100-1/1,000 those of the positive control and in some cases at the apparent level of the negative control (previously measured by the less-sensitive Northern blot analysis) [14].


  1. A critical role of neural-specific JNK3 for ischemic apoptosis. Kuan, C.Y., Whitmarsh, A.J., Yang, D.D., Liao, G., Schloemer, A.J., Dong, C., Bao, J., Banasiak, K.J., Haddad, G.G., Flavell, R.A., Davis, R.J., Rakic, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Specific pathophysiological functions of JNK isoforms in the brain. Brecht, S., Kirchhof, R., Chromik, A., Willesen, M., Nicolaus, T., Raivich, G., Wessig, J., Waetzig, V., Goetz, M., Claussen, M., Pearse, D., Kuan, C.Y., Vaudano, E., Behrens, A., Wagner, E., Flavell, R.A., Davis, R.J., Herdegen, T. Eur. J. Neurosci. (2005) [Pubmed]
  3. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Weston, C.R., Wong, A., Hall, J.P., Goad, M.E., Flavell, R.A., Davis, R.J. Genes Dev. (2003) [Pubmed]
  4. Sunday Driver links axonal transport to damage signaling. Cavalli, V., Kujala, P., Klumperman, J., Goldstein, L.S. J. Cell Biol. (2005) [Pubmed]
  5. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Hunot, S., Vila, M., Teismann, P., Davis, R.J., Hirsch, E.C., Przedborski, S., Rakic, P., Flavell, R.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Inhibited neurogenesis in JNK1-deficient embryonic stem cells. Amura, C.R., Marek, L., Winn, R.A., Heasley, L.E. Mol. Cell. Biol. (2005) [Pubmed]
  7. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. Keramaris, E., Vanderluit, J.L., Bahadori, M., Mousavi, K., Davis, R.J., Flavell, R., Slack, R.S., Park, D.S. J. Biol. Chem. (2005) [Pubmed]
  8. JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. Bruckner, S.R., Tammariello, S.P., Kuan, C.Y., Flavell, R.A., Rakic, P., Estus, S. J. Neurochem. (2001) [Pubmed]
  9. Enhanced contractility of small blood vessels in JNK knockout mice. Laukeviciene, A., Brecht, S., Kevelaitis, E., Herdegen, T. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2006) [Pubmed]
  10. Visual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm. Song, X., Raman, D., Gurevich, E.V., Vishnivetskiy, S.A., Gurevich, V.V. J. Biol. Chem. (2006) [Pubmed]
  11. In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. Xu, P., Yoshioka, K., Yoshimura, D., Tominaga, Y., Nishioka, T., Ito, M., Nakabeppu, Y. J. Biol. Chem. (2003) [Pubmed]
  12. JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons. Bruckner, S.R., Estus, S. J. Neurosci. Res. (2002) [Pubmed]
  13. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. Kimberly, W.T., Zheng, J.B., Town, T., Flavell, R.A., Selkoe, D.J. J. Neurosci. (2005) [Pubmed]
  14. SAPKgamma/JNK1 and SAPKalpha/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells. Zhong, W., Sun, T., Wang, Q.T., Wang, Y., Xie, Y., Johnson, A., Leach, R., Puscheck, E.E., Rappolee, D.A. Fertil. Steril. (2004) [Pubmed]
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