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Gene Review

ZDHHC23  -  zinc finger, DHHC-type containing 23

Homo sapiens

Synonyms: DHHC-23, MGC42530, Palmitoyltransferase ZDHHC23, Zinc finger DHHC domain-containing protein 23, zDHHC23
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Disease relevance of ZDHHC23

  • However, as hyperglycemia develops, basal insulin levels and insulin responses to nonglucose signals are maintained in many NIDD patients by the potentiating effect of hyperglycemia [1].
  • In contrast, GDRs were similar in obese NIDD patients with (n = 15) and without (n = 8) hypertension (802 +/- 90 vs. 849 +/- 90 mumol m-2/min-1, respectively, P = NS) [2].
  • In this study, LV function at rest was evaluated in 2 groups of diabetic patients, with insulin-dependent (IDD; n = 16) and non-insulin-dependent (NIDD; n = 23) diabetes mellitus, with no evidence of coronary artery disease [3].
  • Hyperinsulinemia increased leg glucose metabolism (P<0.001) in all groups, but obese NIDD patients were significantly more insulin resistant [4].
  • Seventeen were healthy controls (C), 24 had gestational diabetes (GD), 16 had type 2 diabetes (NIDD) and 37 had type 1 diabetes (IDD) [5].

High impact information on ZDHHC23

  • Glucose disposal was reduced in the NIDD patients at the three highest plasma insulin concentrations, and this was accounted for by defects in both glucose oxidation and nonoxidative glucose metabolism [6].
  • Both NIDD and nNOS were enriched in synaptosome and synaptic plasma membrane fractions and were present in the lipid raft and postsynaptic density fractions in the rat brain [7].
  • The PDZ dependence was confirmed by an experiment using a deletion mutant, and the interaction was further confirmed by co-sedimentation assays using COS-7 cells transfected with NIDD and nNOS [7].
  • NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity [7].
  • The deduced NIDD protein consisted of 392 amino acid residues and possessed five transmembrane segments, a zinc finger DHHC domain, and a PDZ-binding motif (-EDIV) at its C-terminal tail [7].

Chemical compound and disease context of ZDHHC23

  • In NIDD patients with mild to moderate hyperglycemia (fasting plasma glucose less than 200 mg/dl), chronic sulfonylurea therapy results in the maintenance of near-normal insulin levels, but at a lower plasma glucose level [1].
  • We studied the effect of a continuous subcutaneous insulin infusion (CSII) associated with a low-calorie diet and metformin 1,700 mg/day on glycaemic control and basal and stimulated insulin secretion in a series of 82 overweight NIDD before (T1), during CSII (T2), and after CSII withdrawal (T3) [8].

Biological context of ZDHHC23

  • In contrast, patients with NIDD had significantly reduced cardiac output compared with that of control subjects (5.7 +/- 0.2 vs 5.9 +/- 0.2 liter/min; p < 0.01), and increased systemic vascular resistances (1,422 +/- 137 vs 1,314 +/- 68; p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)[3]
  • Like hypertension, NIDD is mediated by insulin resistance and is expressed in individuals with limited beta-cell reserve [9].

Anatomical context of ZDHHC23

  • Thus, some NIDD patients may show an increase in basal insulin levels during chronic sulfonylurea therapy while others may not; however, all patients who respond to sulfonylureas demonstrate increased B-cell sensitivity to glucose [1].
  • There was no zinc deficiency in the leukocytes of NIDD subjects [10].

Associations of ZDHHC23 with chemical compounds

  • In conclusion, a linoleic-enriched diet in patients with NIDD causes a less atherogenic lipoprotein profile but does not influence glycemic control and carbohydrate tolerance [11].
  • Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD [12].
  • This study has shown for the first time that significant proportions of the Sri Lankan female population may be Se deficient (24, 24 and 40% in the NIDD, MIDD and HIDD villages, respectively) [13].
  • The CPR/IRG molar ratio was similar in control, GD and NIDD women; in the IDD, it was much smaller than in the other groups and was not affected by arginine [5].

Analytical, diagnostic and therapeutic context of ZDHHC23

  • CPR values were similar to, or slightly higher than control values in the GD and the NIDD and were much lower in the IDD women [5].


  1. Acute and chronic effects of sulfonylurea drugs on pancreatic islet function in man. Pfeifer, M.A., Halter, J.B., Judzewitsch, R.G., Beard, J.C., Best, J.D., Ward, W.K., Porte, D. Diabetes Care (1984) [Pubmed]
  2. Essential hypertension and insulin resistance in non-insulin-dependent diabetes. Laakso, M., Sarlund, H., Mykkänen, L. Eur. J. Clin. Invest. (1989) [Pubmed]
  3. Comparison of left ventricular function in insulin- and non-insulin-dependent diabetes mellitus. Ferraro, S., Perrone-Filardi, P., Maddalena, G., Desiderio, A., Gravina, E., Turco, S., Chiariello, M. Am. J. Cardiol. (1993) [Pubmed]
  4. Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. Mandarino, L.J., Consoli, A., Jain, A., Kelley, D.E. Am. J. Physiol. (1996) [Pubmed]
  5. Endocrine pancreatic function in insulin-dependent diabetic pregnant women. Fiore, R., Maldonato, A., Zicari, D., Pimpinella, G., Gargiulo, P., Tinelli, F.P., Arachi, S., Pachi, A., Fallucca, F. Acta endocrinologica. Supplementum. (1986) [Pubmed]
  6. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. Groop, L.C., Bonadonna, R.C., DelPrato, S., Ratheiser, K., Zyck, K., Ferrannini, E., DeFronzo, R.A. J. Clin. Invest. (1989) [Pubmed]
  7. NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. Saitoh, F., Tian, Q.B., Okano, A., Sakagami, H., Kondo, H., Suzuki, T. J. Biol. Chem. (2004) [Pubmed]
  8. Short-term effects of continuous subcutaneous insulin infusion treatment on insulin secretion in non-insulin-dependent overweight patients with poor glycaemic control despite maximal oral anti-diabetic treatment. Valensi, P., Moura, I., Le Magoarou, M., Pariès, J., Perret, G., Attali, J.R. Diabetes Metab. (1997) [Pubmed]
  9. Insulin resistance and preeclampsia. Berkowitz, K.M. Clinics in perinatology. (1998) [Pubmed]
  10. Trace elements in blood cells of diabetic subjects. Raz, I., Havivi, E. Diabetes Res. (1989) [Pubmed]
  11. Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients. Heine, R.J., Mulder, C., Popp-Snijders, C., van der Meer, J., van der Veen, E.A. Am. J. Clin. Nutr. (1989) [Pubmed]
  12. Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD. Noury, J., Nandeuil, A. Diabète & métabolisme. (1991) [Pubmed]
  13. Selenium and iodine in soil, rice and drinking water in relation to endemic goitre in Sri Lanka. Fordyce, F.M., Johnson, C.C., Navaratna, U.R., Appleton, J.D., Dissanayake, C.B. Sci. Total Environ. (2000) [Pubmed]
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