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Gene Review

Plk1  -  polo-like kinase 1

Rattus norvegicus

Synonyms: PLK-1, Plk, Polo-like kinase 1, Serine/threonine-protein kinase PLK1
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High impact information on Plk1

  • These findings identify a Plk1-dependent signalling mechanism potentially linking Golgi structure and cell cycle control, but suggest that this may not be a cell cycle checkpoint in the classical sense [1].
  • Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis [2].
  • These findings suggest that phosphorylation of GRASP65 by Plk may be a critical event in the reorganization of the Golgi structure during mitosis [2].
  • Here, we provide evidence that Plk is involved in the mitosis-specific fragmentation of the Golgi apparatus [2].
  • In this study, Plk1 expression, subcellular localization, and possible functions during rat oocyte meiotic maturation, fertilization, and embryonic cleavages were studied by using RT-PCR, Western blot, confocal microscopy, drug-treatments, and antibody microinjection [3].

Biological context of Plk1

  • In conclusion, Plk1 may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during rat oocyte meiotic maturation, fertilization, and early embryonic mitosis [3].
  • The specific subcellular distribution of Plk1 was distorted after disrupting the M-phase spindle, while additional aggregation dots could be induced in the cytoplasm by taxol, suggesting its intimate association with active microtubule assembly [3].
  • Throughout cytokinesis, Plk1 was localized to the division plane, both during oocyte meiosis and embryonic mitosis [3].

Anatomical context of Plk1


Associations of Plk1 with chemical compounds


Analytical, diagnostic and therapeutic context of Plk1

  • Plk1 antibody microinjection delayed the meiotic resumption and blocked the emission of polar bodies [3].
  • Confocal microscopy revealed that Plk1 distributed abundantly in the nucleus at the germinal vesicle (GV) stage, was associated with spindle poles during the formation of M-phase spindle, and was translocated to the spindle mid-zone at anaphase [3].


  1. Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling. Preisinger, C., Körner, R., Wind, M., Lehmann, W.D., Kopajtich, R., Barr, F.A. EMBO J. (2005) [Pubmed]
  2. Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis. Sütterlin, C., Lin, C.Y., Feng, Y., Ferris, D.K., Erikson, R.L., Malhotra, V. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Characterization of Polo-like kinase-1 in rat oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization, and cleavage. Fan, H.Y., Tong, C., Teng, C.B., Lian, L., Li, S.W., Yang, Z.M., Chen, D.Y., Schatten, H., Sun, Q.Y. Mol. Reprod. Dev. (2003) [Pubmed]
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