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Gene Review

FBXO3  -  F-box protein 3

Homo sapiens

Synonyms: F-box only protein 3, FBA, FBX3
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High impact information on FBXO3

  • Annexin-V could be conjugated with an average of two FBA mole equivalents without decreasing its affinity for red blood cells (K(d) 6-10 nM) with exposed phosphatidylserine [1].
  • Other cytoskeleton-associated proteins increased during development, including UDP-glucose starch glucosyltransferase (UDP-GSGT, EC, sucrose synthase 1 (SuSy-1, EC and fructose-1,6 bisphosphate aldolase (FBA, EC [2].
  • A comparison of the predicted 233-amino acid protein with several fish orthologues indicates a highly conserved sequence containing the F-box associated (FBA) domain and proline-rich motifs (PRM) characteristics of this family [3].
  • Furthermore, we confirmed that blocking PDGF-C signaling by anti-PDGF-C neutralization antibody led to branchial arch malformations similar to that of RA induced, both hypoplastic branchial arches and FBA [4].
  • A statistically significant difference on DNA synthesis was noticed when PDGF-BB was added to PDL cells cultured with FBA [5].

Biological context of FBXO3

  • This additional mode of supervision was performed in combination with continuous cardiotocography (CTG) and intermittent fetal blood sampling (FBA) in cases with suspect, prepathologic or pathologic heart rate patterns [6].

Anatomical context of FBXO3


Associations of FBXO3 with chemical compounds

  • The principal carboxyl-terminal residues determined by the hydrazinolysis method were glycine in SBB 1-3, SBA and FBA, and serine in SBB 4-5 and FBB [8].
  • The principal amino-terminal residues determined by the cyanate method were valine in SBB 1-5 and SBA, and alanine in FBA and FBB [8].

Analytical, diagnostic and therapeutic context of FBXO3

  • A retrospective study to determine how well cardiotocogram (CTG) and micro blood analysis (FBA) results correspond to each other was made on 200 deliveries which had been monitored sub partu by these techniques [9].
  • Fetal monitoring by combined CTG and FBA [7].
  • In cases with reduced SpO2-values as well as lengthy SpO2-registration gaps (limits of acceptability are described) it is urgently advised to use FBA for differential diagnosis so that even in these cases unnecessary operative interventions can be avoided [10].
  • One main and one minor active components, designated as FBA and FBB, respectively, were also separated from crude fruit bromelain by chromatographies on DEAE-Sephacel and then CM-Sephadex [8].
  • METHODS: Two human demineralized freeze-dried allografts of cortical (DFDBA) and cancellous (DFBA) bone and a non-demineralized freeze-dried allograft (FBA) from cancellous bone were used alone or supplemented with PDGF-BB [5].


  1. Production of [F-18]fluoroannexin for imaging apoptosis with PET. Grierson, J.R., Yagle, K.J., Eary, J.F., Tait, J.F., Gibson, D.F., Lewellen, B., Link, J.M., Krohn, K.A. Bioconjug. Chem. (2004) [Pubmed]
  2. Lysine-containing proteins in maize endosperm: a major contribution from cytoskeleton-associated carbohydrate-metabolizing enzymes. Azama, K., Abe, S., Sugimoto, H., Davies, E. Planta (2003) [Pubmed]
  3. Molecular characterization of the nonspecific cytotoxic cell receptor (NCCRP-1) demonstrates gilthead seabream NCC heterogeneity. Cuesta, A., Esteban, M.A., Meseguer, J. Dev. Comp. Immunol. (2005) [Pubmed]
  4. PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid. Han, J., Li, L., Zhang, Z., Xiao, Y., Lin, J., Li, Y. Toxicol. Lett. (2006) [Pubmed]
  5. In vitro evaluation of the mitogenic effect of platelet-derived growth factor-BB on human periodontal ligament cells cultured with various bone allografts. Papadopoulos, C.E., Dereka, X.E., Vavouraki, E.N., Vrotsos, I.A. J. Periodontol. (2003) [Pubmed]
  6. Clinical experience on tcPco2 during labor. Schmidt, S. Journal of perinatal medicine. (1987) [Pubmed]
  7. Fetal monitoring by combined CTG and FBA. Goeschen, K. Journal of perinatal medicine. (1996) [Pubmed]
  8. Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains. Ota, S., Muta, E., Katahira, Y., Okamoto, Y. J. Biochem. (1985) [Pubmed]
  9. Sub partu monitoring of the fetus by cardiotocography and fetal blood analysis. Baer, S., Vetter, K. Journal of perinatal medicine. (1988) [Pubmed]
  10. Fetal pulse oximetry during labor: issues and recommendations for clinical use. Saling, E. Journal of perinatal medicine. (1996) [Pubmed]
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