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Gene Review

TBCB  -  tubulin folding cofactor B

Homo sapiens

Synonyms: CG22, CKAP1, CKAPI, Cytoskeleton-associated protein 1, Cytoskeleton-associated protein CKAPI, ...
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Disease relevance of TBCB


Psychiatry related information on TBCB


High impact information on TBCB


Chemical compound and disease context of TBCB


Biological context of TBCB


Anatomical context of TBCB


Associations of TBCB with chemical compounds


Physical interactions of TBCB


Enzymatic interactions of TBCB


Regulatory relationships of TBCB


Other interactions of TBCB


Analytical, diagnostic and therapeutic context of TBCB


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  2. Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. Lekehal, M., Pessayre, D., Lereau, J.M., Moulis, C., Fouraste, I., Fau, D. Hepatology (1996) [Pubmed]
  3. Cytoskeleton-associated proteins of human lung cancer cells. Bernal, S.D., Baylin, S.B., Shaper, J.H., Gazdar, A.F., Chen, L.B. Cancer Res. (1983) [Pubmed]
  4. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway. Wang, W., Ding, J., Allen, E., Zhu, P., Zhang, L., Vogel, H., Yang, Y. Curr. Biol. (2005) [Pubmed]
  5. Kinesin-mediated transport of neurofilament protein oligomers in growing axons. Yabe, J.T., Pimenta, A., Shea, T.B. J. Cell. Sci. (1999) [Pubmed]
  6. Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease. Vickers, J.C., Delacourte, A., Morrison, J.H. Brain Res. (1992) [Pubmed]
  7. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Keely, P.J., Westwick, J.K., Whitehead, I.P., Der, C.J., Parise, L.V. Nature (1997) [Pubmed]
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  10. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. Grimbert, P., Valanciute, A., Audard, V., Pawlak, A., Le gouvelo, S., Lang, P., Niaudet, P., Bensman, A., Guellaën, G., Sahali, D. J. Exp. Med. (2003) [Pubmed]
  11. Sequence homologies between four cytoskeleton-associated proteins. Riehemann, K., Sorg, C. Trends Biochem. Sci. (1993) [Pubmed]
  12. Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. Meira, D.D., Marinho-Carvalho, M.M., Teixeira, C.A., Veiga, V.F., Da Poian, A.T., Holandino, C., de Freitas, M.S., Sola-Penna, M. Mol. Genet. Metab. (2005) [Pubmed]
  13. The 300-kDa intermediate filament-associated protein (IFAP300) is a hamster plectin ortholog. Clubb, B.H., Chou, Y.H., Herrmann, H., Svitkina, T.M., Borisy, G.G., Goldman, R.D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  14. Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain. Watanabe, T.K., Shimizu, F., Nagata, M., Kawai, A., Fujiwara, T., Nakamura, Y., Takahashi, E., Hirai, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  15. Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. Bertagnolli, M.E., Beckerle, M.C. J. Cell Biol. (1993) [Pubmed]
  16. Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42. Yoshida, H., Tomiyama, Y., Ishikawa, J., Oritani, K., Matsumura, I., Shiraga, M., Yokota, T., Okajima, Y., Ogawa, M., Miyagawa, J., Nishiura, T., Matsuzawa, Y. Blood (2000) [Pubmed]
  17. Stimulated cytokineplasts from human polymorphonuclear leukocytes mobilize calcium and polymerize actin. Cytoplasts made in cytochalasin B retain a defect in actin polymerization. Dyett, D.E., Malawista, S.E., Naccache, P.H., Sha'afi, R.I. J. Clin. Invest. (1986) [Pubmed]
  18. A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport. Vaughan, P.S., Miura, P., Henderson, M., Byrne, B., Vaughan, K.T. J. Cell Biol. (2002) [Pubmed]
  19. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. Ookata, K., Hisanaga, S., Okano, T., Tachibana, K., Kishimoto, T. EMBO J. (1992) [Pubmed]
  20. An inherited defect of neutrophil motility and microfilamentous cytoskeleton associated with abnormalities in 47-Kd and 89-Kd proteins. Coates, T.D., Torkildson, J.C., Torres, M., Church, J.A., Howard, T.H. Blood (1991) [Pubmed]
  21. Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions. Guignandon, A., Lafage-Proust, M.H., Usson, Y., Laroche, N., Caillot-Augusseau, A., Alexandre, C., Vico, L. FASEB J. (2001) [Pubmed]
  22. Dissociation and redistribution of Na+,K(+)-ATPase from its surface membrane actin cytoskeletal complex during cellular ATP depletion. Molitoris, B.A., Geerdes, A., McIntosh, J.R. J. Clin. Invest. (1991) [Pubmed]
  23. Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Chen, X.M., Huang, B.Q., Splinter, P.L., Cao, H., Zhu, G., McNiven, M.A., LaRusso, N.F. Gastroenterology (2003) [Pubmed]
  24. Exon scanning for mutation of the NF2 gene in schwannomas. Jacoby, L.B., MacCollin, M., Louis, D.N., Mohney, T., Rubio, M.P., Pulaski, K., Trofatter, J.A., Kley, N., Seizinger, B., Ramesh, V. Hum. Mol. Genet. (1994) [Pubmed]
  25. Structure and assembly of hemidesmosomes. Jones, J.C., Hopkinson, S.B., Goldfinger, L.E. Bioessays (1998) [Pubmed]
  26. Analysis of the adaptor function of the LIM domain-containing protein FHL2 using an affinity chromatography approach. El Mourabit, H., Müller, S., Tunggal, L., Paulsson, M., Aumailley, M. J. Cell. Biochem. (2004) [Pubmed]
  27. Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets. Ezumi, Y., Takayama, H., Okuma, M. J. Biol. Chem. (1995) [Pubmed]
  28. Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component. Ulker, N., Zhang, X., Samuel, C.E. J. Biol. Chem. (1987) [Pubmed]
  29. Restoration of E-cadherin-based cell-cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line. Peng, Y.F., Mandai, K., Nakanishi, H., Ikeda, W., Asada, M., Momose, Y., Shibamoto, S., Yanagihara, K., Shiozaki, H., Monden, M., Takeichi, M., Takai, Y. Oncogene (2002) [Pubmed]
  30. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. Delaguillaumie, A., Harriague, J., Kohanna, S., Bismuth, G., Rubinstein, E., Seigneuret, M., Conjeaud, H. J. Cell. Sci. (2004) [Pubmed]
  31. New insights into the neurofibromatoses. Gutmann, D.H. Curr. Opin. Neurol. (1994) [Pubmed]
  32. Prevention of EGF-modulated adhesion of tumor cells to matrix proteins by specific EGF receptor inhibition. Genersch, E., Schneider, D.W., Sauer, G., Khazaie, K., Schuppan, D., Lichtner, R.B. Int. J. Cancer (1998) [Pubmed]
  33. Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells. Hofer, M.D., Menke, A., Genze, F., Gierschik, P., Giehl, K. Br. J. Cancer (2004) [Pubmed]
  34. The association of tau-like proteins with vimentin filaments in cultured cells. Capote, C., Maccioni, R.B. Exp. Cell Res. (1998) [Pubmed]
  35. Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures. Pumiglia, K.M., Feinstein, M.B. Biochem. J. (1993) [Pubmed]
  36. Epidermolysis bullosa: novel and de novo premature termination codon and deletion mutations in the plectin gene predict late-onset muscular dystrophy. Rouan, F., Pulkkinen, L., Meneguzzi, G., Laforgia, S., Hyde, P., Kim, D.U., Richard, G., Uitto, J. J. Invest. Dermatol. (2000) [Pubmed]
  37. p120-catenin expression in human colorectal cancer. Skoudy, A., Gomez, S., Fabre, M., Garcia de Herreros, A. Int. J. Cancer (1996) [Pubmed]
  38. Sulfation of guinea pig megakaryocyte and platelet proteins. Schick, B.P., Jacoby, J.A. J. Cell. Physiol. (1994) [Pubmed]
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