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Gene Review

Ceacam2  -  carcinoembryonic antigen-related cell...

Mus musculus

Synonyms: AI267129, BGP-2, Bgp2, Biliary glycoprotein 2, CEA-related cell adhesion molecule 2, ...
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Disease relevance of Ceacam2


High impact information on Ceacam2

  • The Bgp2 cDNA allowed the prediction of a 271-amino-acid glycoprotein with two immunoglobulin domains, a transmembrane, and a putative cytoplasmic tail [1].
  • RNase protection assays and RNA PCR showed that Bgp2 was expressed in BALB/c kidney, colon, and brain tissue, in SJL/J colon and liver tissue, in BALB/c and CD1 spleen tissue, in C3H macrophages, and in mouse rectal carcinoma CMT-93 cells [1].
  • There is considerable divergence in the amino acid sequences of the N-terminal domains of the proteins coded by the Bgp1 gene from that of the Bgp2-encoded protein [1].
  • Reverse transcription-PCR using testis RNA indicated that Ceacam2 in the testis is an alternatively spliced form containing only exons 1, 2, 5, 6, 8 and 9 [3].
  • On the other hand, no Ceacam2 mRNA was detected throughout embryonic development [3].

Chemical compound and disease context of Ceacam2

  • When Bgp2-transfected hamster cells were challenged with MHV-A59, MHV-JHM, or MHV-3, the Bgp2-encoded protein served as a functional MHV receptor, although with a lower efficiency than that of the MHVR glycoprotein [1].

Biological context of Ceacam2

  • While most of these differences were due to nucleotide substitutions, two insertions of 418 and 5849 bp occurred in intron 2 of Ceacam2, and another two insertions of 1384 and 197 bp occurred in introns 5 and 7 respectively [3].

Anatomical context of Ceacam2

  • In contrast, Ceacam2 mRNA was only detected in kidney, testis and, to a lesser extent, spleen [3].
  • The Bgp2 protein is expressed in low amounts in kidney and in a rectal carcinoma cell line [4].
  • Bgp2 was found by immunocytochemistry in smooth muscle layers of the kidney, the uterus, in gut mononuclear cells and in the crypt epithelia of intestinal tissues [4].
  • Both MHV-Y and -RI infected Vero cells transiently transfected with the Bgp2 receptor gene, though only MHV-Y infected CHO cells stably transfected with the Bgp2 receptor gene [5].

Other interactions of Ceacam2

  • The Bgp2-mediated virus infection could not be inhibited by monoclonal antibody CC1 that is specific for the N-terminal domain of MHVR [1].

Analytical, diagnostic and therapeutic context of Ceacam2


  1. Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. Nédellec, P., Dveksler, G.S., Daniels, E., Turbide, C., Chow, B., Basile, A.A., Holmes, K.V., Beauchemin, N. J. Virol. (1994) [Pubmed]
  2. Purified, soluble recombinant mouse hepatitis virus receptor, Bgp1(b), and Bgp2 murine coronavirus receptors differ in mouse hepatitis virus binding and neutralizing activities. Zelus, B.D., Wessner, D.R., Williams, R.K., Pensiero, M.N., Phibbs, F.T., deSouza, M., Dveksler, G.S., Holmes, K.V. J. Virol. (1998) [Pubmed]
  3. Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes. Han, E., Phan, D., Lo, P., Poy, M.N., Behringer, R., Najjar, S.M., Lin, S.H. Biochem. J. (2001) [Pubmed]
  4. Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2. Robitaille, J., Izzi, L., Daniels, E., Zelus, B., Holmes, K.V., Beauchemin, N. Eur. J. Biochem. (1999) [Pubmed]
  5. Interactions of enterotropic mouse hepatitis viruses with Bgp2 receptor proteins. Compton, S.R. Adv. Exp. Med. Biol. (1998) [Pubmed]
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