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Gene Review

Ceacam1  -  carcinoembryonic antigen-related cell...

Rattus norvegicus

Synonyms: ATP-dependent taurocolate-carrier protein, BGPR, Bgp, C-CAM 105, CD66a, ...
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Disease relevance of Ceacam1


High impact information on Ceacam1

  • Cell surface localization and tissue distribution of a hepatocyte cell-cell adhesion glycoprotein (cell-CAM 105) [6].
  • Fluorescence and confocal microscopy, respectively, revealed increased pericanalicular-apical membrane localization of two canalicular markers, peanut agglutinin and a 110-kDa canalicular ecto-ATPase, when hepatocyte couplets were preincubated in HCO3-/CO2-containing medium, an effect that was again blocked by colchicine [7].
  • Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain [8].
  • The identification of pp120 as HA4 serves to link insulin action through the receptor tyrosine kinase activity to bile metabolism and raises questions pertaining to the intracellular site(s) of action of the insulin receptor [8].
  • Analysis of these proteins revealed that protein kinase Calpha and the cell adhesion signaling molecule pp120 formed temporal associations with p130Cas in response to Ang II. c-Src was found to associate with p130Cas in a manner that was independent of Ang II treatment [9].

Chemical compound and disease context of Ceacam1


Biological context of Ceacam1

  • The results of this study also show that the canalicular ecto-ATPase/bile acid transport protein is phosphorylated on its cytoplasmic tail and that its phosphorylation is stimulated by activation of protein kinase C and inhibited by inhibitors of protein kinase C activation [12].
  • The amino acid sequence of the ecto-ATPase from rat liver was deduced from analysis of cDNA clones and a genomic clone [13].
  • In order to definitively determine whether these were two activities of a single polypeptide, we examined the possibility that transfection of cDNA for the ecto-ATPase would confer bile acid transport characteristics, as well as ecto-ATPase activity, on heterologous cells [12].
  • Because the short isoform of ecto-ATPase lacks the putative sites for tyrosine- and serine-specific phosphorylation, this alternative splicing may have a major effect upon the physiological function of the enzyme [14].
  • The association of ATPase activity with cell-CAM105 raises the possibility that extracellular nucleotides may play important roles in regulating cell adhesion [15].

Anatomical context of Ceacam1


Associations of Ceacam1 with chemical compounds

  • The insulin receptor possesses tyrosine kinase activity which is thought to mediate the biological effects of insulin upon target cells. pp120 is a liver-specific glycoprotein of apparent molecular size of 120 kDa that is phosphorylated on tyrosine residues by the receptors for insulin, insulin-like growth factor-I, and epidermal growth factor [14].
  • Since the mural trophoblast cells are the first to adhere to the uterine luminal epithelium during the onset of implantation and subsequently invade the uterine stroma, we suggest that the apparent downregulation of cell-CAM 105 in the mural trophoblast cells might be linked to the acquisition of trophoblast invasiveness [17].
  • In contrast, although dexamethasone elevated GP 110 in fetal rat livers, none of the other marker proteins was significantly affected [18].
  • Immunoprecipitation analysis of PHC induced by ethionine or diethylnitrosamine and choline-deficient diet showed that one of four PHC was expressing an altered form of cell-CAM 105 with the more basic pI characteristic of the THC form of this molecule [1].
  • Bile acid transport activity was completely abrogated in cells transfected with the T502A, S503A mutant cDNA and was retained but altered in kinetic characteristics in cells transfected with the Y488F mutant cDNA, even though both of these constructs conferred ecto-ATPase activity to the same extent as the wild type cDNA [19].

Enzymatic interactions of Ceacam1


Other interactions of Ceacam1


Analytical, diagnostic and therapeutic context of Ceacam1


  1. Detection of an altered form of cell-CAM 105 on rat transplantable and primary hepatocellular carcinomas. Hixson, D.C., McEntire, K.D. Cancer Res. (1989) [Pubmed]
  2. Comparison of the structural characteristics of cell-CAM 105 from hepatocytes with those of an altered form expressed by rat transplantable hepatocellular carcinomas. McEntire, K.D., Mowery, J., Hixson, D.C. Cancer Res. (1989) [Pubmed]
  3. Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages. Chen, B.C., Lee, C.M., Lin, W.W. Br. J. Pharmacol. (1996) [Pubmed]
  4. Tumor-suppressive activity of CD66a in prostate cancer. Luo, W., Tapolsky, M., Earley, K., Wood, C.G., Wilson, D.R., Logothetis, C.J., Lin, S.H. Cancer Gene Ther. (1999) [Pubmed]
  5. Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine. Walton, N.Y., Nagy, A.K., Treiman, D.M. J. Mol. Neurosci. (1998) [Pubmed]
  6. Cell surface localization and tissue distribution of a hepatocyte cell-cell adhesion glycoprotein (cell-CAM 105). Ocklind, C., Forsum, U., Obrink, B. J. Cell Biol. (1983) [Pubmed]
  7. Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Benedetti, A., Strazzabosco, M., Ng, O.C., Boyer, J.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Margolis, R.N., Taylor, S.I., Seminara, D., Hubbard, A.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  9. Phosphorylation of p130Cas by angiotensin II is dependent on c-Src, intracellular Ca2+, and protein kinase C. Sayeski, P.P., Ali, M.S., Harp, J.B., Marrero, M.B., Bernstein, K.E. Circ. Res. (1998) [Pubmed]
  10. Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor. Phillips, S.A., Perrotti, N., Taylor, S.I. FEBS Lett. (1987) [Pubmed]
  11. Selective chemical modification of plasma membrane ectoenzymes. Salem, N., Lauter, C.J., Trams, E.G. Biochim. Biophys. Acta (1981) [Pubmed]
  12. The rat liver ecto-ATPase is also a canalicular bile acid transport protein. Sippel, C.J., Suchy, F.J., Ananthanarayanan, M., Perlmutter, D.H. J. Biol. Chem. (1993) [Pubmed]
  13. Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I. Lin, S.H., Guidotti, G. J. Biol. Chem. (1989) [Pubmed]
  14. pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. Najjar, S.M., Accili, D., Philippe, N., Jernberg, J., Margolis, R., Taylor, S.I. J. Biol. Chem. (1993) [Pubmed]
  15. Immunochemical characterization of two isoforms of rat liver ecto-ATPase that show an immunological and structural identity with a glycoprotein cell-adhesion molecule with Mr 105,000. Lin, S.H., Culic, O., Flanagan, D., Hixson, D.C. Biochem. J. (1991) [Pubmed]
  16. The cytoplasmic domain of C-CAM is required for C-CAM-mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron. Cheung, P.H., Culic, O., Qiu, Y., Earley, K., Thompson, N., Hixson, D.C., Lin, S.H. Biochem. J. (1993) [Pubmed]
  17. Trophectoderm surface expression of the cell adhesion molecule cell-CAM 105 on rat blastocysts. Svalander, P.C., Odin, P., Nilsson, B.O., Obrink, B. Development (1987) [Pubmed]
  18. The effect of dexamethasone and glucagon on the expression of hepatocyte plasma membrane proteins during development. Bujanover, Y., Amarri, S., Lebenthal, E., Petell, J.K. Hepatology (1988) [Pubmed]
  19. Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. Sippel, C.J., Fallon, R.J., Perlmutter, D.H. J. Biol. Chem. (1994) [Pubmed]
  20. CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes. Singer, B.B., Klaile, E., Scheffrahn, I., Müller, M.M., Kammerer, R., Reutter, W., Obrink, B., Lucka, L. Eur. J. Immunol. (2005) [Pubmed]
  21. Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence. McCaughan, G.W., Wickson, J.E., Creswick, P.F., Gorrell, M.D. Hepatology (1990) [Pubmed]
  22. Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase. Najjar, S.M., Boisclair, Y.R., Nabih, Z.T., Philippe, N., Imai, Y., Suzuki, Y., Suh, D.S., Ooi, G.T. J. Biol. Chem. (1996) [Pubmed]
  23. The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth. Schieffer, B., Bernstein, K.E., Marrero, M.B. J. Mol. Med. (1996) [Pubmed]
  24. Molecular cloning and expression of a new rat liver cell-CAM105 isoform. Differential phosphorylation of isoforms. Culic, O., Huang, Q.H., Flanagan, D., Hixson, D., Lin, S.H. Biochem. J. (1992) [Pubmed]
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