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Gene Review

ANKRD1  -  ankyrin repeat domain 1 (cardiac muscle)

Homo sapiens

Synonyms: ALRP, Ankyrin repeat domain-containing protein 1, C-193, C193, CARP, ...
 
 
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Disease relevance of ANKRD1

  • Compared with controls treated with an empty vector or with antisense cDNA, the ectopic expression of ANKRD1 led to reduced colony formation and to enhanced apoptotic cell death in hepatoma cells [1].
  • These novel ankyrin-rich proteins are related to C-193/CARP/MARP, a cardiac protein involved in the control of cardiac hypertrophy [2].
  • In confirmation and extension of observations by Carp and his associates, brain tissue and sera from patients with multiple sclerosis (MS) were found to harbor an agent which induces a transitory depression in polymorphonuclear leukocytes (PMN) in mice as well as in rats, hamsters, and guinea pigs [3].
  • These findings suggest that ANKRD1, a gene not previously associated with ovarian cancer or with response to chemotherapy, is associated with treatment outcome, and decreasing ANKRD1 expression, or function, is a potential strategy to sensitize tumors to platinum-based drugs [4].
 

High impact information on ANKRD1

  • These results suggest that ANKRD1 and the other genes, whose expressions were substantially modulated by the parthenolide-mediated inhibition of NF-kappaB activation, play roles in the enhanced drug-induced apoptosis [1].
  • CARP appears to be the rat homolog of a previously reported human single-copy gene (C-193; Chu, W., Burns, D. K., Swerlick, R. A., and Presky, D. H. (1995) J. Biol. Chem. 270, 10236-10245), whose mRNA is inducible by cytokines only in human endothelial cells [5].
  • The compiled cDNA sequence of C-193 is 1901 base pairs long and shows no significant homology with any known gene sequence [6].
  • The C-193 gene was localized to human chromosome 10 by Southern blot analysis of somatic cell hybrids [6].
  • Lipopolysaccharide and cycloheximide were also potent inducers of C-193 mRNA [6].
 

Biological context of ANKRD1

  • By differential screening of a cDNA library prepared from interleukin-1 alpha and tumor necrosis factor-alpha-stimulated human dermal microvascular endothelial cells, we have identified a novel cytokine-inducible gene, designated as C-193 [6].
  • In vitro translation of C-193 yielded a 36-kDa protein product, consistent with the predicted open reading frame of 318 amino acids and a calculated molecular mass of 36 kDa for C-193 protein [6].
 

Anatomical context of ANKRD1

 

Associations of ANKRD1 with chemical compounds

  • Structural changes of the peptide alpha(181-200) induced by substitution of P194 or P197 with two adjacent Gly residues, and insertion of a Gly between C192 and C193, were also incompatible with alpha-BTX binding [9].
  • The interaction of V and DDB1 involves the carboxyl-terminal domain of V in that either deletion of the V carboxyl-terminal domain or substitution of the cysteine residues (C189, C193, C205, C207, C210, C214, and C217) in the zinc-binding domain with alanine was able to disrupt binding to DDB1 [10].
 

Analytical, diagnostic and therapeutic context of ANKRD1

  • Protein sequence analysis revealed that Arpp is homologous (52.7% identity) to Carp which is shown to be involved in the regulation of the transcription of the cardiac ventricular myosin light chain 2 gene [11].

References

  1. Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells. Park, J.H., Liu, L., Kim, I.H., Kim, J.H., You, K.R., Kim, D.G. Cancer Res. (2005) [Pubmed]
  2. Characterization of human skeletal muscle Ankrd2. Pallavicini, A., Kojić, S., Bean, C., Vainzof, M., Salamon, M., Ievolella, C., Bortoletto, G., Pacchioni, B., Zatz, M., Lanfranchi, G., Faulkner, G., Valle, G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Multiple sclerosis-associated agent: transmission to animals and some properties of the agent. Koldovsky, U., Koldovsky, P., Henle, G., Henle, W., Ackermann, R., Haase, G. Infect. Immun. (1975) [Pubmed]
  4. Ankyrin repeat domain 1, ANKRD1, a novel determinant of cisplatin sensitivity expressed in ovarian cancer. Scurr, L.L., Guminski, A.D., Chiew, Y.E., Balleine, R.L., Sharma, R., Lei, Y., Pryor, K., Wain, G.V., Brand, A., Byth, K., Kennedy, C., Rizos, H., Harnett, P.R., deFazio, A. Clin. Cancer Res. (2008) [Pubmed]
  5. A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes. Jeyaseelan, R., Poizat, C., Baker, R.K., Abdishoo, S., Isterabadi, L.B., Lyons, G.E., Kedes, L. J. Biol. Chem. (1997) [Pubmed]
  6. Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells. Chu, W., Burns, D.K., Swerlick, R.A., Presky, D.H. J. Biol. Chem. (1995) [Pubmed]
  7. ANKRD1 specifically binds CASQ2 in heart extracts and both proteins are co-enriched in piglet cardiac Purkinje cells. Torrado, M., Nespereira, B., López, E., Centeno, A., Castro-Beiras, A., Mikhailov, A.T. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  8. Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. Hofhaus, G., Stein, G., Polimeno, L., Francavilla, A., Lisowsky, T. Eur. J. Cell Biol. (1999) [Pubmed]
  9. An alpha-bungarotoxin-binding sequence on the Torpedo nicotinic acetylcholine receptor alpha-subunit: conservative amino acid substitutions reveal side-chain specific interactions. McLane, K.E., Wu, X., Conti-Tronconi, B.M. Biochemistry (1994) [Pubmed]
  10. The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein. Lin, G.Y., Paterson, R.G., Richardson, C.D., Lamb, R.A. Virology (1998) [Pubmed]
  11. Identification of a novel human ankyrin-repeated protein homologous to CARP. Moriyama, M., Tsukamoto, Y., Fujiwara, M., Kondo, G., Nakada, C., Baba, T., Ishiguro, N., Miyazaki, A., Nakamura, K., Hori, N., Sato, K., Shomori, K., Takeuchi, K., Satoh, H., Mori, S., Ito, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
 
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