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Gene Review

SIGLEC8  -  sialic acid binding Ig-like lectin 8

Homo sapiens

Synonyms: MGC59785, SAF-2, SAF2, SIGLEC-8, SIGLEC8L, ...
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High impact information on SIGLEC8


Biological context of SIGLEC8


Anatomical context of SIGLEC8


Associations of SIGLEC8 with chemical compounds

  • Previous studies demonstrated sialic acid-dependent binding of Siglec-8 but failed to reveal significant substructure specificity or high affinity of that binding [2].
  • We conclude that Siglec-8 binds preferentially to the sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl [2].
  • Like the other members of the CD33-like subgroup of Siglecs, except for the previously published Siglec8, Siglec8-L also contains the two tyrosine-based motifs that have been found to recruit both SH2 domain-containing tyrosine and inositol phosphatases [5].
  • It was shown that siglecs-1, -4, -5, -6, -7, -9, and -10 did not interact with these compounds; binding of 6-O-Su-3'SiaLacNAc and 6-O-Su-3'SiaTF to siglec-8 was weaker than that of the corresponding sulfate-free sialoside probes [7].

Other interactions of SIGLEC8

  • The SLG gene is localized 32.9 kb downstream of Siglec-8 on chromosome 19q13 [8].
  • The glycan pools from siglec-5 and siglec-7 contained a larger proportion of sialylated and core-fucosylated biantennary, triantennary and tetra-antennary oligosaccharides, whereas the carbohydrate mixture released from siglec-8 is noticeably less sialylated and is more abundant in 'high-mannose'-type glycans [9].

Analytical, diagnostic and therapeutic context of SIGLEC8


  1. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Nutku, E., Aizawa, H., Hudson, S.A., Bochner, B.S. Blood (2003) [Pubmed]
  2. Glycan array screening reveals a candidate ligand for Siglec-8. Bochner, B.S., Alvarez, R.A., Mehta, P., Bovin, N.V., Blixt, O., White, J.R., Schnaar, R.L. J. Biol. Chem. (2005) [Pubmed]
  3. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. Floyd, H., Ni, J., Cornish, A.L., Zeng, Z., Liu, D., Carter, K.C., Steel, J., Crocker, P.R. J. Biol. Chem. (2000) [Pubmed]
  4. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. Kikly, K.K., Bochner, B.S., Freeman, S.D., Tan, K.B., Gallagher, K.T., D'alessio, K.J., Holmes, S.D., Abrahamson, J.A., Erickson-Miller, C.L., Murdock, P.R., Tachimoto, H., Schleimer, R.P., White, J.R. J. Allergy Clin. Immunol. (2000) [Pubmed]
  5. Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene. Foussias, G., Yousef, G.M., Diamandis, E.P. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Nutku, E., Hudson, S.A., Bochner, B.S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. Rapoport, E.M., Pazynina, G.V., Sablina, M.A., Crocker, P.R., Bovin, N.V. Biochemistry Mosc. (2006) [Pubmed]
  8. Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs. Foussias, G., Taylor, S.M., Yousef, G.M., Tropak, M.B., Ordon, M.H., Diamandis, E.P. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. A comparative study of the asparagine-linked oligosaccharides on siglec-5, siglec-7 and siglec-8, expressed in a CHO cell line, and their contribution to ligand recognition. Freeman, S., Birrell, H.C., D'Alessio, K., Erickson-Miller, C., Kikly, K., Camilleri, P. Eur. J. Biochem. (2001) [Pubmed]
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