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Gene Review

Defb3  -  defensin beta 3

Mus musculus

Synonyms: BD-3, Bd3, Beta-defensin 3, Defensin, beta 3, mBD-3
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Disease relevance of Defb3

  • Recombinant mBD-3 peptide, produced from a baculovirus expression system, showed antimicrobial activity against P. aeruginosa PAO1 (MIC of 8 micrograms/ml) and Escherichia coli D31 (MIC of 16 micrograms/ml) in a salt-dependent manner [1].
  • After instillation of Pseudomonas aeruginosa PAO1 into mouse airways, mBD-3-specific mRNA was upregulated significantly not only in large airways but also in the small bowel and liver [1].
  • The kinetics of gene expression and the cellular source of murine beta -defensin-3 (mBD3) and murine beta -defensin-4 (mBD4) were determined in mouse models of progressive pulmonary tuberculosis and latent infection induced by high or low infecting doses, respectively [2].
  • We conclude that mBD-3 is an inducible peptide with limited tissue expression during E. coli peritonitis [3].
  • Synthetic mBD-3 inhibited the growth of E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans at concentrations from 25 to 50 microg/mL [3].

High impact information on Defb3


Chemical compound and disease context of Defb3

  • Three of the tested compounds, 5-(p-nitrobenzamido)-2-benzylbenzoxazole (BD-3), 6-methyl-2-(o-chlorophenyl) benzoxazole (A-9) and 5-(p-nitrophenoxyacetamido)-2-phenylbenzoxazole (D-30), showed an increased apoptotic effect on mouse lymphoma cells [5].

Biological context of Defb3


Other interactions of Defb3

  • Gf C57BL/6 and BALB/c mice expressed significantly different basal levels of mBD3, mBD4, TNF-alpha and IL-12 in gastric tissues; however, gf C57BL/6 and BALB/c mice were equally susceptible to intestinal colonization with C. albicans and had similar fungal burdens in gastric tissues 4 weeks after oral challenge [6].

Analytical, diagnostic and therapeutic context of Defb3

  • Constitutive expression of mBD-3 mRNA was not consistently found in any organ using RT-PCR [3].
  • The antimicrobial activity of synthetic mBD-3 was evaluated in microdilution broth assays using bacterial and fungal organisms. mBD-3 mRNA expression was assayed by polymerase chain reaction (PCR) using cDNA derived from a panel of tissues [3].


  1. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Bals, R., Wang, X., Meegalla, R.L., Wattler, S., Weiner, D.J., Nehls, M.C., Wilson, J.M. Infect. Immun. (1999) [Pubmed]
  2. beta-Defensin gene expression during the course of experimental tuberculosis infection. Rivas-Santiago, B., Sada, E., Tsutsumi, V., Aguilar-Leon, D., Contreras, J.L., Hernandez-Pando, R. J. Infect. Dis. (2006) [Pubmed]
  3. Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity. Burd, R.S., Furrer, J.L., Sullivan, J., Smith, A.L. Shock (2002) [Pubmed]
  4. Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., Ouchi, Y. J. Immunol. (2002) [Pubmed]
  5. Induction of apoptosis and necrosis by resistance modifiers benzazoles and benzoxazines on tumour cell line mouse lymphoma L5718 Mdr+cells. Varga, A., Aki-Sener, E., Yalcin, I., Temiz-Arpaci, O., Tekiner-Gulbas, B., Cherepnev, G., Molnar, J. In Vivo (2005) [Pubmed]
  6. Divergent chemokine, cytokine and beta-defensin responses to gastric candidiasis in immunocompetent C57BL/6 and BALB/c mice. Schofield, D.A., Westwater, C., Balish, E. J. Med. Microbiol. (2005) [Pubmed]
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