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Gene Review

Tswt  -  testis weight

Mus musculus

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Disease relevance of Tswt


High impact information on Tswt


Chemical compound and disease context of Tswt


Biological context of Tswt


Anatomical context of Tswt


Associations of Tswt with chemical compounds


Other interactions of Tswt

  • Testis weight was reduced in Pss2-deficient mice, and some of the male mice were infertile [30].
  • The testis weight and the degree of spermatogenesis in cryptorchidized normal (jsd/+) and jsd mutant mice were almost identical [31].
  • Weanling hpg mice were administered hCG (0.1-100 IU i.p. injection three times weekly) or T (1-cm subdermal Silastic implant) for 6 weeks, after which stereological estimates of germinal cell populations, serum and testicular T content, and testis weight were evaluated [20].
  • Administration of 80 or 160 micrograms testosterone oenanthate s.c. three times per week for 8 or 12 weeks reduced testis weight and increased seminal vesicle weight in mice [32].

Analytical, diagnostic and therapeutic context of Tswt


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  7. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Bedard, N., Hingamp, P., Pang, Z., Karaplis, A., Morales, C., Trasler, J., Cyr, D., Gagnon, C., Wing, S.S. Mol. Cell. Biol. (2005) [Pubmed]
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  12. Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats. Yang, H.J., Lee, S.H., Jin, Y., Choi, J.H., Han, C.H., Lee, M.H. J. Vet. Sci. (2005) [Pubmed]
  13. Damage of the mouse testis by tritiated water and 137Cs-gamma-rays. Kashiwabara, S., Kashimoto, N., Sanoh, S., Uesaka, T., Katoh, O., Watanabe, H. Hiroshima J. Med. Sci. (2003) [Pubmed]
  14. Environmental temperature and cryptorchidism: effects on pregnenolone-sulfatase of mice testicular tissue. Valencia-Sánchez, A., Ortega-Corona, B.G., Campos-Lara, G., Ponce-Monter, H. Arch. Androl. (1996) [Pubmed]
  15. Correlation of sperm and endocrine measures with reproductive success in rodents. Gray, L.E., Ostby, J., Ferrell, J., Sigmon, R., Cooper, R., Linder, R., Rehnberg, G., Goldman, J., Laskey, J. Prog. Clin. Biol. Res. (1989) [Pubmed]
  16. Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies. Oka, A., Mita, A., Sakurai-Yamatani, N., Yamamoto, H., Takagi, N., Takano-Shimizu, T., Toshimori, K., Moriwaki, K., Shiroishi, T. Genetics (2004) [Pubmed]
  17. A targeted mutation of Nkd1 impairs mouse spermatogenesis. Li, Q., Ishikawa, T.O., Miyoshi, H., Oshima, M., Taketo, M.M. J. Biol. Chem. (2005) [Pubmed]
  18. Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice. Lue, Y., Sinha Hikim, A.P., Wang, C., Leung, A., Swerdloff, R.S. Endocrinology (2003) [Pubmed]
  19. Relative biological effectiveness (RBE) of p(26) + Be neutrons from the King Faisal Specialist Hospital and Research Centre CS-30 cyclotron measured by testis weight loss. Feola, J.M., Aissi, A., Greer, W., el-Sayed, R., Clubb, B., el-Akkad, S. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1989) [Pubmed]
  20. Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone. Spaliviero, J.A., Jimenez, M., Allan, C.M., Handelsman, D.J. Biol. Reprod. (2004) [Pubmed]
  21. Estrogenic induction of spermatogenesis in the hypogonadal mouse. Ebling, F.J., Brooks, A.N., Cronin, A.S., Ford, H., Kerr, J.B. Endocrinology (2000) [Pubmed]
  22. Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages. França, L.R., Suescun, M.O., Miranda, J.R., Giovambattista, A., Perello, M., Spinedi, E., Calandra, R.S. Endocrinology (2006) [Pubmed]
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  24. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Ryu, B.Y., Orwig, K.E., Oatley, J.M., Avarbock, M.R., Brinster, R.L. Stem Cells (2006) [Pubmed]
  25. Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Shimshek, D.R., Bus, T., Grinevich, V., Single, F.N., Mack, V., Sprengel, R., Spergel, D.J., Seeburg, P.H. Mol. Endocrinol. (2006) [Pubmed]
  26. Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation. Handelsman, D.J., Spaliviero, J.A., Simpson, J.M., Allan, C.M., Singh, J. Endocrinology (1999) [Pubmed]
  27. Genetic toxicology of phthalate esters: mutagenic and other genotoxic effects. Douglas, G.R., Hugenholtz, A.P., Blakey, D.H. Environ. Health Perspect. (1986) [Pubmed]
  28. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. Choi, Y.J., Ok, D.W., Kwon, D.N., Chung, J.I., Kim, H.C., Yeo, S.M., Kim, T., Seo, H.G., Kim, J.H. FEBS Lett. (2004) [Pubmed]
  29. Transferrin treatment corrects aging-related immunologic and hormonal decay in old mice. Pierpaoli, W., Bulian, D., Arrighi, S. Exp. Gerontol. (2000) [Pubmed]
  30. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo, M.O., Gavino, B.J., Steenbergen, R., Sturbois, B., Parlow, A.F., Sanan, D.A., Skarnes, W.C., Vance, J.E., Young, S.G. J. Biol. Chem. (2002) [Pubmed]
  31. Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice. Shetty, G., Weng, C.C. Endocrinology (2004) [Pubmed]
  32. Effect of testosterone oenanthate on spermatogenesis and serum testosterone concentrations in adult mice. Bansal, M.R., Davies, A.G. J. Reprod. Fertil. (1986) [Pubmed]
  33. The effects of the age of intracerebroventricular grafts of normal preoptic area tissue upon pituitary and gonadal function in hypogonadal (HPG) mice. Charlton, H.M., Jones, A.J., Whitworth, D., Gibson, M.J., Kokoris, G., Zimmerman, E.A., Silverman, A.J. Neuroscience (1987) [Pubmed]
  34. Influence of teniposide (VM-26) on radiation-induced damage to mouse spermatogenesis: a flow cytometric evaluation. Jyothi, P., Jagetia, G.C., Krishnamurthy, H. Reprod. Toxicol. (1998) [Pubmed]
  35. Investigation of thermotolerance in mouse testis. Marigold, J.C., Hume, S.P., Hand, J.W. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1985) [Pubmed]
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