The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MSR1  -  macrophage scavenger receptor 1

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MSR1


High impact information on MSR1

  • We report here that lipid IVA binding and subsequent metabolism to a less active form by macrophage-like RAW 264.7 cells is mediated by the macrophage scavenger receptor [2].
  • The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis [3].
  • AGE proteins are taken up by macrophages via the AGE receptor, which is similar to the macrophage scavenger receptor (MSR) [4].
  • The growth-stimulating effect of Ox-LDL on murine resident peritoneal macrophages was inhibited by maleylated bovine serum albumin (maleyl-BSA), a non-lipoprotein ligand for MSR but a poor carrier of lyso-PC, while maleyl-BSA itself failed to induce macrophage growth even in the presence of lyso-PC [5].
  • Furthermore, the Ox-LDL-induced cell growth of peritoneal macrophages obtained from MSR knockout mice was significantly weaker than that of macrophages obtained from their wild-type littermates [5].

Biological context of MSR1

  • Furthermore, these results suggest that MSR ligands can block cytokine induction by plasmid DNA whether or not the plasmid contains extended runs of dG [6].
  • Macrophage scavenger receptor is a trimerized membrane protein that binds ligands and undergoes internalization by endocytosis [7].
  • The macrophage scavenger receptor exhibits a pH-dependent conformational change around the carboxy-terminal half of the alpha-helical coiled coil domain, which has a representative amino acid sequence of a (defgabc)n heptad [8].
  • In a 24-h culture, silica (250 microg/ml) induced significant cell injury (necrosis and apoptosis) in transfected cells (MSR II) but not in the control cells (KA-7) [9].
  • It is a single polypeptide chain of 1413 amino acids consisting of 11 non-identical repeats of a 110 amino acid consensus sequence, homologous to the macrophage scavenger receptor cysteine rich (SRCR) domain [10].

Anatomical context of MSR1

  • Northern blot analysis using the cDNA for the macrophage scavenger receptor revealed that these CHO cells did not express this receptor [11].
  • Studies with oligonucleotides indicate that dG sequences can directly stimulate B cells as well as enhance the activity of immunostimulatory CpG motifs because of interaction with the macrophage scavenger receptor (MSR); this receptor can bind a variety of polyanions including dG sequences [6].
  • Transient expression of full-length, native type II MSR in COS-1 cells conferred adhesion to denatured type I collagens, whereas expression of a truncated receptor lacking the distal portion of the collagenous domain did not [12].
  • Immunoelectron microscopic studies using both AGE-BSA conjugated with gold particles and anti-(bovine MSR) antibody (D2) revealed co-localization of gold particles and the reactive sites for the antibody at coated pits of plasma membranes as well as in endosomes [13].

Associations of MSR1 with chemical compounds

  • Role of the buried glutamate in the alpha-helical coiled coil domain of the macrophage scavenger receptor [8].
  • These domains resemble motifs of the LDL receptor (two copies), complement component Clr (two copies), the metalloprotease meprin (one copy), and the macrophage scavenger receptor (one copy) [14].
  • These results indicate that the electrostatic interaction of oxLDL with some component(s) of the heparin-bound fraction might interfere with the endocytic uptake of oxLDL by the macrophage scavenger receptor [15].
  • This effect was specific to silica, as a control particle titanium dioxide had no cytotoxic effects on the MSR II cells at equal particle mass concentrations [9].
  • Furthermore, silica-induced apoptosis in the MSR II cells could be eliminated by preincubating the cells with SR-A II antagonists: polyinosinic acid or maleylated bovine serum albumin [9].

Other interactions of MSR1


  1. The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid. Dunne, D.W., Resnick, D., Greenberg, J., Krieger, M., Joiner, K.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Recognition and plasma clearance of endotoxin by scavenger receptors. Hampton, R.Y., Golenbock, D.T., Penman, M., Krieger, M., Raetz, C.R. Nature (1991) [Pubmed]
  3. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama, T., Freeman, M., Rohrer, L., Zabrecky, J., Matsudaira, P., Krieger, M. Nature (1990) [Pubmed]
  4. Advanced glycation end products and their recognition by macrophage and macrophage-derived cells. Horiuchi, S., Higashi, T., Ikeda, K., Saishoji, T., Jinnouchi, Y., Sano, H., Shibayama, R., Sakamoto, T., Araki, N. Diabetes (1996) [Pubmed]
  5. The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation. Sakai, M., Miyazaki, A., Hakamata, H., Kodama, T., Suzuki, H., Kobori, S., Shichiri, M., Horiuchi, S. J. Biol. Chem. (1996) [Pubmed]
  6. The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. Wloch, M.K., Pasquini, S., Ertl, H.C., Pisetsky, D.S. Hum. Gene Ther. (1998) [Pubmed]
  7. The conformation of the alpha-helical coiled coil domain of macrophage scavenger receptor is pH dependent. Suzuki, K., Doi, T., Imanishi, T., Kodama, T., Tanaka, T. Biochemistry (1997) [Pubmed]
  8. Role of the buried glutamate in the alpha-helical coiled coil domain of the macrophage scavenger receptor. Suzuki, K., Yamada, T., Tanaka, T. Biochemistry (1999) [Pubmed]
  9. Class A type II scavenger receptor mediates silica-induced apoptosis in Chinese hamster ovary cell line. Hamilton, R.F., de Villiers, W.J., Holian, A. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  10. A novel multi-gene family of sheep gamma delta T cells. Walker, I.D., Glew, M.D., O'Keeffe, M.A., Metcalfe, S.A., Clevers, H.C., Wijngaard, P.L., Adams, T.E., Hein, W.R. Immunology (1994) [Pubmed]
  11. Chinese hamster ovary cells expressing a novel type of acetylated low density lipoprotein receptor. Isolation and characterization. Fukasawa, M., Hirota, K., Adachi, H., Mimura, K., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., Inoue, K. J. Biol. Chem. (1995) [Pubmed]
  12. The collagenous domain of class A scavenger receptors is involved in macrophage adhesion to collagens. Gowen, B.B., Borg, T.K., Ghaffar, A., Mayer, E.P. J. Leukoc. Biol. (2001) [Pubmed]
  13. Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction. Araki, N., Higashi, T., Mori, T., Shibayama, R., Kawabe, Y., Kodama, T., Takahashi, K., Shichiri, M., Horiuchi, S. Eur. J. Biochem. (1995) [Pubmed]
  14. cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen. Kitamoto, Y., Veile, R.A., Donis-Keller, H., Sadler, J.E. Biochemistry (1995) [Pubmed]
  15. The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages. Suginohara, Y., Miyazaki, A., Hakamata, H., Sakamoto, Y., Ohta, T., Matsuda, I., Horiuchi, S. Atherosclerosis (1996) [Pubmed]
  16. Complexes of a modified low-molecular-weight heparin with protamine are predominantly cleared by a macrophage scavenger receptor-mediated process in rats. Stehle, G., Wunder, A., Sinn, H., Schrenk, H.H., Friedrich, E.A., Dempfle, C.E., Maier-Borst, W., Heene, D.L. J. Surg. Res. (1995) [Pubmed]
WikiGenes - Universities