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Chemical Compound Review

POLY I     [3,4-dihydroxy-5-(6-oxo-3H- purin-9...

Synonyms: PolyI, Polyinosine, Poly r I, Poly(rI), AG-D-64989, ...
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Disease relevance of ribosylhypoxanthine monophosphate


High impact information on ribosylhypoxanthine monophosphate

  • Furthermore, the degradation of WHHL-VLDL was not blocked by either fucoidin, polyinosinic acid, or polyguanylic acid, potent inhibitors of the acetylated (acetyl)-LDL binding site, or by acetyl-LDL [6].
  • Moreover, when mice treated with the urate oxidase inhibitor potassium oxonate were fed inosine or inosinic acid, serum UA levels were elevated markedly for a period of hours, whereas only a minor, transient increase in serum inosine was detected [7].
  • Uptake of Aco-HSA liposomes by both endothelial and Kupffer cells was inhibited by preinjection with polyinosinic acid, indicating the involvement of scavenger receptors in the uptake process [8].
  • Inhibitors of scavenger receptor binding, including polyinosinic acid and fucoidin, also prevented binding of the oxidized red blood cells [9].
  • Rather than inhibiting chemotaxis, acetyl LDL showed intrinsic positive chemotactic activity as did also fucoidin and polyinosinic acid, both of which also interact with the acetyl-LDL receptor [10].

Chemical compound and disease context of ribosylhypoxanthine monophosphate


Biological context of ribosylhypoxanthine monophosphate


Anatomical context of ribosylhypoxanthine monophosphate


Associations of ribosylhypoxanthine monophosphate with other chemical compounds

  • Complexing with polyinosinic acid also decreased the rate of degradation of [35S]MPC as evidenced by an increase of the trichloroacetic acid-precipitable fraction (i.e., oligonucleotides larger than five to ten nucleotide units), from 0.45 to 0.92 of the total radioactivity in plasma 60 min postinjection [26].
  • Polyanionic ligands of the macrophage scavenger receptor (SR) for acetylated-LDL caused marked inhibition of AM binding of the oxide particles and latex beads (e.g., TiO2 binding; polyinosinic acid (polyl), 10 micrograms/ml: 70.2 +/- 1.5% inhibition, mean +/- SE, n = 11) [27].
  • Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis [28].
  • We now find that, in the presence of MgCl2, KCl, and inosine-5'-monophosphate as phosphate donor, purified cytosolic 5'-nucleotidase catalyzed the phosphorylation of ddlno [29].
  • The observed stimulation in macrophage uPA secretion by heparin is similar to that previously reported for polyanions recognized by the scavenger receptor including fucoidan, polyinosinic acid, dextran sulfate, and acetyl-LDL (Falcone and Ferenc: J. Cell. Physiol., 135:387-396, 1988) [30].

Gene context of ribosylhypoxanthine monophosphate


Analytical, diagnostic and therapeutic context of ribosylhypoxanthine monophosphate


  1. Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole. Lowe, J.K., Brox, L., Henderson, J.F. Cancer Res. (1977) [Pubmed]
  2. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Lee, H.J., Pawlak, K., Nguyen, B.T., Robins, R.K., Sadée, W. Cancer Res. (1985) [Pubmed]
  3. Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells. Cass, C.E., Lowe, J.K., Manchak, J.M., Henderson, J.F. Cancer Res. (1977) [Pubmed]
  4. Variations in the contribution of induced interferon and adjuvanticity to the antiviral effect of different polyinosinic acid . polycytidylic acid formulations in mice infected with encephalomyocarditis virus. Stebbing, N., Lindley, I.J., Dawson, K.M. Infect. Immun. (1980) [Pubmed]
  5. Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic acid . polycytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine. Harrington, D.G., Crabbs, C.L., Hilmas, D.E., Brown, J.R., Higbee, G.A., Cole, F.E., Levy, H.B. Infect. Immun. (1979) [Pubmed]
  6. Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia. Kita, T., Yokode, M., Watanabe, Y., Narumiya, S., Kawai, C. J. Clin. Invest. (1986) [Pubmed]
  7. Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. Scott, G.S., Spitsin, S.V., Kean, R.B., Mikheeva, T., Koprowski, H., Hooper, D.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells. Kamps, J.A., Morselt, H.W., Swart, P.J., Meijer, D.K., Scherphof, G.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein. Sambrano, G.R., Parthasarathy, S., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein. Quinn, M.T., Parthasarathy, S., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  11. OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase. Lei, Z.B., Zhang, Z., Jing, Q., Qin, Y.W., Pei, G., Cao, B.Z., Li, X.Y. Cardiovasc. Res. (2002) [Pubmed]
  12. Retinoic acid and polyriboinosinic acid act synergistically to enhance the antibody response to tetanus toxoid during vitamin A deficiency: possible involvement of interleukin-2 receptor-beta, signal transducer and activator of transcription-1, and interferon regulatory factor-1. DeCicco, K.L., Zolfaghari, R., Li, N., Ross, A.C. J. Infect. Dis. (2000) [Pubmed]
  13. Phosphorylation of nucleosides by the mutated acid phosphatase from Morganella morganii. Mihara, Y., Utagawa, T., Yamada, H., Asano, Y. Appl. Environ. Microbiol. (2000) [Pubmed]
  14. Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver. Fabianowska-Majewska, K., Duley, J.A., Simmonds, H.A. Biochem. Pharmacol. (1994) [Pubmed]
  15. Biochemical mechanisms of resistance to tiazofurin. Jayaram, H.N. Adv. Enzyme Regul. (1985) [Pubmed]
  16. Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. Terpstra, V., van Berkel, T.J. Blood (2000) [Pubmed]
  17. Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase. Fridland, A., Connelly, M.C., Robbins, T.J. Cancer Res. (1986) [Pubmed]
  18. Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines. Collart, F.R., Chubb, C.B., Mirkin, B.L., Huberman, E. Cancer Res. (1992) [Pubmed]
  19. Potential role for scavenger receptors of human monocytes in the killing of Schistosoma mansoni. Xu, X., Remold, H.G., Caulfield, J.P. Am. J. Pathol. (1993) [Pubmed]
  20. Amplification of the inosinate dehydrogenase gene in Trypanosoma brucei gambiense due to an increase in chromosome copy number. Wilson, K., Berens, R.L., Sifri, C.D., Ullman, B. J. Biol. Chem. (1994) [Pubmed]
  21. Adenosine production in the ischemic kidney. Miller, W.L., Thomas, R.A., Berne, R.M., Rubio, R. Circ. Res. (1978) [Pubmed]
  22. Visualization of the interaction of native and modified lipoproteins with parenchymal, endothelial and Kupffer cells from human liver. Kleinherenbrink-Stins, M.F., van de Boom, J.H., Schouten, D., Roholl, P.J., Niels van der Heyde, M., Brouwer, A., van Berkel, T.J., Knook, D.L. Hepatology (1991) [Pubmed]
  23. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages. Lougheed, M., Zhang, H.F., Steinbrecher, U.P. J. Biol. Chem. (1991) [Pubmed]
  24. Cellular mechanism of endotoxin unresponsiveness in C3H/HeJ mice. Glode, L.M., Scher, I., Osborne, B., Rosenstreich, D.L. J. Immunol. (1976) [Pubmed]
  25. Specific interaction of oxidized low-density lipoprotein with macrophage-derived foam cells isolated from rabbit atherosclerotic lesions. de Vries, H.E., Buchner, B., van Berkel, T.J., Kuiper, J. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  26. Plasma clearance and tissue distribution of partially thiolated polycytidylic acid and its degradation products in rodents. Kung, M.P., Ho, Y.K., Lalka, D., Bardos, T.J. Cancer Res. (1984) [Pubmed]
  27. Lung macrophage uptake of unopsonized environmental particulates. Role of scavenger-type receptors. Kobzik, L. J. Immunol. (1995) [Pubmed]
  28. Linkage of the loci for glucose-6-phosphate dehydrogenase and for inosinic acid pyrophosphorylase to the X chromosome of the field-vole Microtus agrestis. Cook, P.R. J. Cell. Sci. (1975) [Pubmed]
  29. Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells. Johnson, M.A., Fridland, A. Mol. Pharmacol. (1989) [Pubmed]
  30. Heparin stimulation of plasminogen activator secretion by macrophage-like cell line RAW264.7: role of the scavenger receptor. Falcone, D.J. J. Cell. Physiol. (1989) [Pubmed]
  31. Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7. Campa, V.M., Iglesias, J.M., Carcedo, M.T., Rodríguez, R., Riera, J., Ramos, S., Lazo, P.S. Inflamm. Res. (2005) [Pubmed]
  32. Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists. Kazemi, M.R., McDonald, C.M., Shigenaga, J.K., Grunfeld, C., Feingold, K.R. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  33. Oxidized low-density lipoprotein stimulates protein kinase C (PKC) and induces expression of PKC-isotypes via prostaglandin-H-synthase in P388D1 macrophage-like cells. Claus, R., Fyrnys, B., Deigner, H.P., Wolf, G. Biochemistry (1996) [Pubmed]
  34. Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. Park, S.Y., Lee, J.H., Kim, Y.K., Kim, C.D., Rhim, B.Y., Lee, W.S., Hong, K.W. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  35. A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO. Chen, Y., Sankala, M., Ojala, J.R., Sun, Y., Tuuttila, A., Isenman, D.E., Tryggvason, K., Pikkarainen, T. J. Biol. Chem. (2006) [Pubmed]
  36. Circular dichroism calculations for polyinosinic acid in proposed multi-stranded geometries. Cech, C.L., Tinoco, I. Nucleic Acids Res. (1976) [Pubmed]
  37. Gamma-interferon induction in patients with chronic progressive MS. Bever, C.T., Panitch, H.S., Levy, H.B., McFarlin, D.E., Johnson, K.P. Neurology (1991) [Pubmed]
  38. Polyanions inhibit binding of human autoantibodies to certain cellular proteins. Kabakov, A.E., Griaznova, Y.B., Saenko, V.A., Poverenny, A.M. Immunol. Lett. (1990) [Pubmed]
  39. Inosinic acid 5'-monophosphate dehydrogenase of Escherichia coli: purification by affinity chromatography and some properties. Krishnaiah, K.V. Arch. Biochem. Biophys. (1975) [Pubmed]
  40. Metabolism changes in single human fibres during brief maximal exercise. Karatzaferi, C., de Haan, A., van Mechelen, W., Sargeant, A.J. Exp. Physiol. (2001) [Pubmed]
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