Disease relevance of ASC

• AIMS: The present study was designed to determine the individual and combined effects of acidified sodium chlorite (ASC, 0.1%, 24 +/- 1 degrees C), cetylpyridinium chloride (CPC, 0.5%, 24 +/- 1 degrees C) and hot water (HW, 93 +/- 1 degrees C) treatments on the survival of Listeria monocytogenes and Staphylococcus aureus [1].

High impact information on ASC

• Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development [2].
• 3. Uptake of proline, glycine and glutamine via system ASC was identified by inhibition with alanine or serine [3].
• 4. System Gly was identified by the inhibition of glycine transport with excess sarcosine (a substrate for system Gly) whilst systems A and ASC were inhibited [3].
• Na+ -dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removal [4].
• System A transports Pro, Ala, His, Asn, Ser, and Gln; system ASC transports Ser, Gly, Met, Val, Leu, Ile, Cys, and Thr; system N transports Gln, His, Ser, and Asn; Na+ -LNAA transports Leu, Ile, Val, Trp, Tyr, Phe, Met, Ala, His, Thr, and Gly [4].

Associations of ASC with chemical compounds

• Specific transport components of lysine uptake were estimated to be: 63% occurring through the cationic (Y+) system, 17% via the neutral alanine (A) and alanine, serine, cysteine (ASC) amino acid transport systems, and 20% through nonsaturable processes [5].
• The specific transport components of methionine uptake were estimated as 54% occurring through the neutral branched chain leucine (L) systems, 28% through the ASC system, 15% through the A system and 25% through nonsaturable processes [5].
• Phase 1 tested water, SH, PAA, LA, and 0.5% CPC on meat inoculated with non-acid-habituated pathogen populations, whereas phase 2 tested water, SC, AH, ASC, LA, and 0.1% CPC on meat inoculated with acid- and non-acid-habituated populations [6].
• Reductions from phase 2 for acid-habituated cells increased in the order NT = water = SC < ASC = LA = AH < CPC, whereas on non-acid-habituated cells the order observed was NT = water = SC < AH = ASC < LA < CPC [6].

References