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Gene Review

Pycard  -  PYD and CARD domain containing

Mus musculus

Synonyms: 9130417A21Rik, Apoptosis-associated speck-like protein containing a CARD, Asc, CARD5, PYD and CARD domain-containing protein, ...
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Disease relevance of Pycard

  • A comparison of the initial rates of aminoacylation of tRNAs isolated from different sources for 17 amino acids was performed. tRNA was isolated from NMRI mouse liver (tRNA L) and from Krebs II ascites tumors (tRNA Asc), and aminoacyl-tRNA synthetases were prepared from the latter cells [1].
  • Extracted antigen (Asc) and eggs that had been killed also were able to induce marked eosinophilia; however, their levels were significantly lower (p less than 0.001) [2].

High impact information on Pycard


Biological context of Pycard


Anatomical context of Pycard

  • Upon stimulation with LPS, Asc(-/-) macrophages failed in the processing of procaspase-1 and maturation of pro-IL-1beta and pro-IL-18, but normally produced other pro-inflammatory cytokines including TNF-alpha and IL-6 [5].
  • It is possible to measure Asc.- easily using ESR and a dialysis method in which Asc.- was collected at room temperature in the interstitial fluid through the dialysis membrane [6].
  • To study the effect of antigenic competition on T and B cells, donor mice of one or the other cell type received in addition the competitor antigen (Asc) at immunization [7].

Associations of Pycard with chemical compounds

  • These results suggest that the amount of HO. and O2.- produced is reflected in the Asc.- production [6].
  • The addition of ferrous ions and ascorbic acid (Fe2+/ Asc) to mouse sperm suspensions increases the formation of thiobarbituric acid-reactive substances (TBARS), an indicator of lipid peroxide breakdown products, without significantly affecting the level of sulfhydryl groups [8].
  • Also, the increase in Asc.- production when WR-2721 was administered prior to irradiation was less than for experiments in which irradiation only was performed [6].
  • Asc.- increased after treatment with the agents H2O2 and FeCl2, while it decreased after treatment with SOD and catalase [6].

Analytical, diagnostic and therapeutic context of Pycard


  1. Comparison of the rate of aminoacylation of tRNA isolated from NMRI mouse liver with tRNA isolated from Krebs II ascites or mouse plasmacytoma cells. Berg, B.H., Pryme, I.F. Cancer Lett. (1981) [Pubmed]
  2. Eosinophilia in mouse regulated by multiple factors following repeated stimulations with ascaris eggs into the peritoneal cavity. Kano, S., Kasuya, S., Ohtomo, H. Int. Arch. Allergy Appl. Immunol. (1989) [Pubmed]
  3. Regulation of antibody response in different immunoglobulin classes. II. Induction of in vitro IgE antibody response in murine spleen cells and demonstration of a possible involvement of distinct T-helper cells in IgE and IgG antibody responses. Kimoto, M., Kishimoto, T., Noguchi, S., Watanabe, T., Yamamura, Y. J. Immunol. (1977) [Pubmed]
  4. Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Masumoto, J., Taniguchi, S., Nakayama, K., Ayukawa, K., Sagara, J. Exp. Cell Res. (2001) [Pubmed]
  5. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Yamamoto, M., Yaginuma, K., Tsutsui, H., Sagara, J., Guan, X., Seki, E., Yasuda, K., Yamamoto, M., Akira, S., Nakanishi, K., Noda, T., Taniguchi, S. Genes Cells (2004) [Pubmed]
  6. Detection of an increase in ascorbate radical in an irradiated experimental tumour system using ESR. Isoda, H., Akagi, K., Hasegawa, T., Tanaka, Y., Kihara, T., Sakata, S., Ikeda, M. Int. J. Radiat. Biol. (1995) [Pubmed]
  7. Antigenic competition in IgE antibody production. III. Suppressive effect on Th and B cells. Soares, M.F., de Macedo, M.S., Perini, A., Mota, I. Int. Arch. Allergy Appl. Immunol. (1986) [Pubmed]
  8. Effect of sperm lipid peroxidation on fertilization. Kodama, H., Kuribayashi, Y., Gagnon, C. J. Androl. (1996) [Pubmed]
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