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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Krt13  -  keratin 13, type I

Rattus norvegicus

Synonyms: CK-13, Cytokeratin-13, K13, Ka13, Keratin, type I cytoskeletal 13, ...
 
 
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Disease relevance of Ka13

  • To understand the mechanisms underlying the cortical lesions, urinary tract infection was induced in three-week-old rats by an intravesical infusion of E. coli, type 06 K13 HL a rat nephropathogenic strain [1].
  • Acute pyelonephritis in rats caused by Escherichia coli O6K13H1 produced serum and urinary antibodies against O6 and K13 antigens [2].
 

High impact information on Ka13

  • We studied the immune response and the colonization pattern in vitamin A-deficient rats that were colonized with the Escherichia coli O6 K13 pOmp 21 strain, which is genetically manipulated to produce ovalbumin and to be resistant to ampicillin [3].
  • K13 was the only mRNA expressed in both neuronal and non-neuronal cell populations, including the cells of choroid plexus and pia [4].
  • Thus, a-Id treatment in the first generation gave, in the second generation, a greatly enhanced serum antibody response to the spatially related antigens OVA and O6 LPS, as well as to the idiotypically connected antigen K13 [5].
  • In the anterior nasal cavity level 1 (NL1), changes in CK expression patterns were observed in the respiratory epithelium of the lateral wall and the maxilloturbinate (CK14, CK15, and CK18) and in the squamous epithelium of the ventral meatus (CK13) [6].
  • This phenotype was accompanied by loss of transglutaminase (TGase) type II and keratin 18 and expression of the squamous markers TGase type I and keratin 13 [7].
 

Anatomical context of Ka13

 

Other interactions of Ka13

  • Unique immunohistochemically detectable changes in CK expression were the loss of CK 13 expression in invasive TCC cells and the loss of CK 19 expression in induced TCC [9].
 

Analytical, diagnostic and therapeutic context of Ka13

  • During the 21-week period the mean oral load of C. albicans in the control group of rats varied between (26-274) x 10(1) cfu/ml whereas the two test groups of rats carrying C. krusei CK9 and CK13 had a mean load of (2-10) x 10(1) cfu/ml [10].

References

  1. Pyelonephritis provokes growth retardation and apoptosis in infant rat renal cortex. Serlachius, E., Sundelin, B., Eklöf, A.C., Jahnke, M., Laestadius, A., Aperia, A. Kidney Int. (1997) [Pubmed]
  2. Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity. Kaijser, B., Larsson, P., Olling, S. Infect. Immun. (1978) [Pubmed]
  3. Increased translocation of Escherichia coli and development of arthritis in vitamin A-deficient rats. Wiedermann, U., Hanson, L.A., Bremell, T., Kahu, H., Dahlgren, U.I. Infect. Immun. (1995) [Pubmed]
  4. Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Verma-Kurvari, S., Border, B., Joho, R.H. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  5. Antibodies given orally in the neonatal period can affect the immune response for two generations: evidence for active maternal influence on the newborn's immune system. Lundin, B.S., Dahlman-Höglund, A., Pettersson, I., Dahlgren, U.I., Hanson, L.A., Telemo, E. Scand. J. Immunol. (1999) [Pubmed]
  6. Cytokeratin expression patterns in the rat respiratory tract as markers of epithelial differentiation in inhalation toxicology. II. Changes in cytokeratin expression patterns following 8-day exposure to room-aged cigarette sidestream smoke. Schlage, W.K., Bülles, H., Friedrichs, D., Kuhn, M., Teredesai, A., Terpstra, P.M. Toxicologic pathology. (1998) [Pubmed]
  7. Rat tracheal epithelial cell differentiation in vitro. Kaartinen, L., Nettesheim, P., Adler, K.B., Randell, S.H. In Vitro Cell. Dev. Biol. Anim. (1993) [Pubmed]
  8. Changes in cytokeratin, vimentin and desmoplakin distribution during the repair of irradiation-induced lung injury in adult rats. Kasper, M., Rudolf, T., Haase, M., Schuh, D., Müller, M. Virchows Arch., B, Cell Pathol. (1993) [Pubmed]
  9. Correlation of DNA ploidy levels with altered cytokeratin patterns in rat bladder tumors. Reedy, E.A., Cottrell, J.R., Resau, J.H. Pathobiology (1991) [Pubmed]
  10. The relative pathogenicity of Candida krusei and C. albicans in the rat oral mucosa. Samaranayake, Y.H., Wu, P.C., Samaranayake, L.P., Ho, P.L. J. Med. Microbiol. (1998) [Pubmed]
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