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Gene Review

Krt18  -  keratin 18, type I

Rattus norvegicus

Synonyms: CK-18, Cytokeratin-18, K18, Keratin, type I cytoskeletal 18, Keratin-18, ...
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Disease relevance of Krt1-18

  • The results show that K18 expression in cells may result in the suppression of the motile and tumorigenic abilities of this adenocarcinoma [1].
  • Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected [2].

High impact information on Krt1-18

  • In this study, we investigated the potential stem cell marker Thy1 and hepatocytic marker CK-18 during liver development to identify putative fetal liver stem cell candidates [3].
  • In conclusion, hepatic progenitor cells (CK-18 positive) in fetal rat liver express Thy1 [3].
  • All SHs at day 10 immunocytochemically showed positivity for albumin, transferrin, CK8, and CK18, which are markers for hepatocytes [4].
  • The results reported here show first, that CKs are expressed before sexual differentiation in gonadal blastema in which no epithelial organization is observed, and second, that there is a CK 18/CK 19 shift in expression during morphogenesis of the testis which is not observed in the differentiating ovary [5].
  • Under these growth-restrictive conditions, immunocytochemical analysis shows that NRP-152 cells acquire the luminal markers Z0-1 (a tight-junction associated protein), occludin (integral tight-junction protein), and cytokeratin 18, and lose the basal markers cytokeratins 5 and 14 [6].

Biological context of Krt1-18


Anatomical context of Krt1-18


Associations of Krt1-18 with chemical compounds


Other interactions of Krt1-18

  • Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat [7].
  • At the onset of testicular differentiation, when the first Sertoli cells differentiate in the gonad of 13.5-day old male fetuses, positive staining for CK 18 became evident, in addition to CK 8 and CK 19 expression [5].
  • Immunohistochemistry was performed on the induced tumors using four commercially available monoclonal antibodies specific for CK 18 (TR1031), CK 13 (K8.12), CK 19 (K4.62), and the CKs 5, 7, and 8 (K8.13) [19].
  • These results suggest that expression of cytokeratin 18, a later phenotypic change in foci than induction of GST-P and GGT, correlates more closely with tumour outcome in this model [20].
  • Lung specimens from all animals were examined for the presence of apoptosis in type II pneumocytes by an in situ apoptosis assay and for proliferative nuclear antigen, cytokeratin-18, Fas, and Fas ligand with an immunohistochemical stain [21].

Analytical, diagnostic and therapeutic context of Krt1-18


  1. Contrasting effects of K8 and K18 on stabilizing K19 expression, cell motility and tumorigenicity in the BSp73 adenocarcinoma. Pankov, R., Simcha, I., Zöller, M., Oshima, R.G., Ben-Ze'ev, A. J. Cell. Sci. (1997) [Pubmed]
  2. Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis. Jeong, W.I., Jeong, D.H., Do, S.H., Yang, H.J., Hong, I.H., Chang, S.J., Yuan, D.W., Kwak, D.M., Kim, T.H., Kim, Y.K., Lee, I.S., Jeong, K.S. In Vivo (2005) [Pubmed]
  3. Characterization of cell types during rat liver development. Fiegel, H.C., Park, J.J., Lioznov, M.V., Martin, A., Jaeschke-Melli, S., Kaufmann, P.M., Fehse, B., Zander, A.R., Kluth, D. Hepatology (2003) [Pubmed]
  4. Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. Mitaka, T., Sato, F., Mizuguchi, T., Yokono, T., Mochizuki, Y. Hepatology (1999) [Pubmed]
  5. Differential expression of acidic cytokeratins 18 and 19 during sexual differentiation of the rat gonad. Fridmacher, V., Locquet, O., Magre, S. Development (1992) [Pubmed]
  6. Transdifferentiation of NRP-152 rat prostatic basal epithelial cells toward a luminal phenotype: regulation by glucocorticoid, insulin-like growth factor-I and transforming growth factor-beta. Danielpour, D. J. Cell. Sci. (1999) [Pubmed]
  7. Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat. Fridmacher, V., Le Bert, M., Guillou, F., Magre, S. Mech. Dev. (1995) [Pubmed]
  8. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. Toivola, D.M., Goldman, R.D., Garrod, D.R., Eriksson, J.E. J. Cell. Sci. (1997) [Pubmed]
  9. Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. Auten, R.L., Whorton, M.H., Nicholas Mason, S. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  10. Cytokeratin expression patterns in the rat respiratory tract as markers of epithelial differentiation in inhalation toxicology. II. Changes in cytokeratin expression patterns following 8-day exposure to room-aged cigarette sidestream smoke. Schlage, W.K., Bülles, H., Friedrichs, D., Kuhn, M., Teredesai, A., Terpstra, P.M. Toxicologic pathology. (1998) [Pubmed]
  11. Regulation of cytokeratin expression in rat lung alveolar epithelial cells in vitro. Paine, R., Gaposchkin, D., Kelly, C., Wilcoxen, S.E. Am. J. Physiol. (1995) [Pubmed]
  12. Oxygen and glucocorticoids modulate alphaENaC mRNA translation in fetal distal lung epithelium. Otulakowski, G., Rafii, B., Harris, M., O'Brodovich, H. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  13. Estrogen treatment of Dunning tumors in castrated rats: qualitative and quantitative morphology. Landström, M., Bergh, A., Thornell, L.E., Virtanen, I., Damber, J.E. Prostate (1992) [Pubmed]
  14. Cytoskeletal markers allowing discrimination between brush cells and other epithelial cells of the gut including enteroendocrine cells. Höfer, D., Drenckhahn, D. Histochem. Cell Biol. (1996) [Pubmed]
  15. Hepatic lineages isolated from developing rat liver show different ways of maturation. Fiegel, H.C., Kluth, J., Lioznov, M.V., Holzhüter, S., Fehse, B., Zander, A.R., Kluth, D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  16. Site-specificity of ethanol-induced dephosphorylation of rat hepatocyte keratins 8 and 18: A 31P NMR study. Eckert, B.S., Yeagle, P.L. Cell Motil. Cytoskeleton (1996) [Pubmed]
  17. Evidence for post-transcriptional regulation of cytokeratin gene expression in a rat liver epithelial cell line. Blouin, R., Swierenga, S.H., Marceau, N. Biochem. Cell Biol. (1992) [Pubmed]
  18. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. Akino, K., Akita, S., Mizuguchi, T., Takumi, I., Yu, R., Wang, X.Y., Rozga, J., Demetriou, A.A., Melmed, S., Ohtsuru, A., Yamashita, S. J. Surg. Res. (2005) [Pubmed]
  19. Correlation of DNA ploidy levels with altered cytokeratin patterns in rat bladder tumors. Reedy, E.A., Cottrell, J.R., Resau, J.H. Pathobiology (1991) [Pubmed]
  20. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers. Manson, M.M., Hudson, E.A., Ball, H.W., Barrett, M.C., Clark, H.L., Judah, D.J., Verschoyle, R.D., Neal, G.E. Carcinogenesis (1998) [Pubmed]
  21. Fas/Fas ligand pathway is involved in the resolution of type II pneumocyte hyperplasia after acute lung injury: evidence from a rat model. Wang, H.C., Shun, C.T., Hsu, S.M., Kuo, S.H., Luh, K.T., Yang, P.C. Crit. Care Med. (2002) [Pubmed]
  22. Alterations of hepatocellular intermediate filaments during extrahepatic cholestasis in rat liver. Song, J.Y., Van Noorden, C.J., Frederiks, W.M. Virchows Arch. (1997) [Pubmed]
  23. Hepatocytic gene expression in cultured rat mesenchymal stem cells. Lange, C., Bassler, P., Lioznov, M.V., Bruns, H., Kluth, D., Zander, A.R., Fiegel, H.C. Transplant. Proc. (2005) [Pubmed]
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