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Gene Review

KRT13  -  keratin 13, type I

Homo sapiens

Synonyms: CK-13, CK13, Cytokeratin-13, K13, Keratin, type I cytoskeletal 13, ...
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Disease relevance of KRT13


High impact information on KRT13


Chemical compound and disease context of KRT13

  • Monoclonal antibodies against Escherichia coli type 1 pili and the K13 capsular polysaccharide strongly influenced the interaction between human polymorphonuclear leucocytes (PMNL) and E. coli 06:K13:H1 [9].

Biological context of KRT13


Anatomical context of KRT13


Associations of KRT13 with chemical compounds

  • In warts of RTRs, retinoid treatment correlated significantly with a particularly strong, segmental K13 expression pattern, which we termed zebroid [14].
  • Treatment of epidermal cells with arotinoid Ro 13-6298, a potent synthetic analog of retinoic acid, increased the abundance of mRNA for keratin 13 by 25-fold and for keratin 19 by greater than 40-fold but had no effect on the abundance of mRNA for keratins 5 and 6 [15].
  • Furthermore, in the rabbit implantation chambers, CK13 was predominantly localized at the cell apex of luminal epithelial cells, where it assembled into a dense filamentous network [13].
  • The expression of CK13 was reduced in epithelial cells cultured on the titanium alloy, as compared with commercially pure titanium [16].
  • After acitretin treatment, an increase in K13 (P =.006) and K19 (P =.05) was found, together with a change in expression towards a focal or band-like staining pattern [17].

Physical interactions of KRT13


Regulatory relationships of KRT13

  • CK 19 and 14 were expressed only in the basal layer while CK 13 was found selectively n the spinal cells [19].
  • In contrast, expression of a dominant negative STAT3 (Y705F) inhibited the expression of keratin 13 [20].
  • Inclusion of EGF induced abnormal differentiation with minimal expression of keratin 13 [21].
  • Taken together, the present data suggest that cholesteatoma is a hyperproliferative disease and that cholesteatoma expresses CK 16 near the external ear canal and transforms to express CK 13 during growth distally [22].

Other interactions of KRT13

  • Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients [14].
  • OBJECTIVES: To search for possible mutations in KRT4 and KRT13 [23].
  • Long-range restriction mapping analysis of clone 211F11 and of two smaller YAC clones that were also isolated with KRT13-specific primers, suggests that KRT13, 14, 15, 16 and their linked type I genes KRT17 and 19, are contained in less than 150 kb of genomic DNA [24].
  • A cytokeratin mixture lacking CK13 was ineffective as an inhibitor of binding [2].
  • The parabasal cell layers reacted intensely to the cRNA probe complementary to CK16 mRNA, as were the reactions in the suprabasal cell layers of the PJE for the CK 13 and 4 probes [25].

Analytical, diagnostic and therapeutic context of KRT13

  • We now show by Southern blot hybridization and PFGE analyses that KRT13, 14, 15, and 16 are all contained within YAC clone 211F11 [24].
  • Western blots of BEC extracts probed with a specific monoclonal antibody to CK13 confirmed the identification [2].
  • Colocalization of CK13 and B. cepacia by confocal microscopy demonstrated that intact nonpermeabilized NHBE cells express small amounts of surface CK13 and bind Cbl-positive B. cepacia in the same location [2].
  • Tryptic peptides of keratin 13 were separated on a HPLC column and one peptide was sequenced [12].
  • Human cytokeratin 13 is one of the most abundant intermediate filament (IF) proteins of many internal stratified epithelia and occurs, at least in certain cell cultures, in an O-glycosylated form binding the lectin, wheat germ agglutinin (WGA) [26].


  1. Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients. Dorn, J., Schmitt, M., Kates, R., Schmalfeldt, B., Kiechle, M., Scorilas, A., Diamandis, E.P., Harbeck, N. Clin. Cancer Res. (2007) [Pubmed]
  2. Cable-piliated Burkholderia cepacia binds to cytokeratin 13 of epithelial cells. Sajjan, U.S., Sylvester, F.A., Forstner, J.F. Infect. Immun. (2000) [Pubmed]
  3. A novel mutation in the keratin 13 gene causing oral white sponge nevus. Terrinoni, A., Rugg, E.L., Lane, E.B., Melino, G., Felix, D.H., Munro, C.S., McLean, W.H. J. Dent. Res. (2001) [Pubmed]
  4. Intermediate filaments as differentiation markers of normal pancreas and pancreas cancer. Schüssler, M.H., Skoudy, A., Ramaekers, F., Real, F.X. Am. J. Pathol. (1992) [Pubmed]
  5. Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. Richard, G., De Laurenzi, V., Didona, B., Bale, S.J., Compton, J.G. Nat. Genet. (1995) [Pubmed]
  6. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells. Stürzl, M., Hohenadl, C., Zietz, C., Castanos-Velez, E., Wunderlich, A., Ascherl, G., Biberfeld, P., Monini, P., Browning, P.J., Ensoli, B. J. Natl. Cancer Inst. (1999) [Pubmed]
  7. Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. Kedes, D.H., Lagunoff, M., Renne, R., Ganem, D. J. Clin. Invest. (1997) [Pubmed]
  8. Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. Kopan, R., Traska, G., Fuchs, E. J. Cell Biol. (1987) [Pubmed]
  9. The effect of monoclonal antibodies against Escherichia coli type 1 pili and capsular polysaccharides on the interaction between bacteria and human granulocytes. Söderström, T., Ohman, L. Scand. J. Immunol. (1984) [Pubmed]
  10. Chromosomal mapping of human cytokeratin 13 gene (KRT13). Romano, V., Raimondi, E., Bosco, P., Feo, S., Di Pietro, C., Leube, R.E., Troyanovsky, S.M., Ceratto, N. Genomics (1992) [Pubmed]
  11. Isolation, sequence and expression of the gene encoding human keratin 13. Waseem, A., Alam, Y., Dogan, B., White, K.N., Leigh, I.M., Waseem, N.H. Gene (1998) [Pubmed]
  12. Sequence of a human keratin 13 specific cDNA encompassing coil 1B through the 3' end. Schulz, P., Wachter, E., Hochstrasser, K., Wild, A.G., Mischke, D. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  13. Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium. Olson, G.E., Winfrey, V.P., Blaeuer, G.L., Palisano, J.R., NagDas, S.K. Biol. Reprod. (2002) [Pubmed]
  14. Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients. Blokx, W.A., Smit, J.V., de Jong, E.M., Link, M.M., van de Kerkhof, P.C., Ruiter, D.J. Archives of dermatology. (2002) [Pubmed]
  15. Cloning of cDNAs specifying vitamin A-responsive human keratins. Eckert, R.L., Green, H. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. Cytokeratin expression in human oral gingival epithelial cells: in vitro regulation by titanium-based implant materials. Lagneau, C., Farges, J.C., Exbrayat, P., Lissac, M. Biomaterials (1998) [Pubmed]
  17. Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects. Smit, J.V., de Sévaux, R.G., Blokx, W.A., van de Kerkhof, P.C., Hoitsma, A.J., de Jong, E.M. J. Am. Acad. Dermatol. (2004) [Pubmed]
  18. Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium. Urban, T.A., Goldberg, J.B., Forstner, J.F., Sajjan, U.S. Infect. Immun. (2005) [Pubmed]
  19. Increased expression of cytokeratins 14, 18 and 19 correlates with tumor progression in the uterine cervix. Nair, S.A., Nair, M.B., Jayaprakash, P.G., Rajalekshmy, T.N., Nair, M.K., Pillai, M.R. Pathobiology (1997) [Pubmed]
  20. Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium. Wu, R., Sun, S., Steinberg, B.M. Mol. Med. (2003) [Pubmed]
  21. Laryngeal papilloma cells have high levels of epidermal growth factor receptor and respond to epidermal growth factor by a decrease in epithelial differentiation. Vambutas, A., Di Lorenzo, T.P., Steinberg, B.M. Cancer Res. (1993) [Pubmed]
  22. Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. Sasaki, H., Huang, C.C. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1994) [Pubmed]
  23. A novel mutation in the keratin 4 gene causing white sponge naevus. Chao, S.C., Tsai, Y.M., Yang, M.H., Lee, J.Y. Br. J. Dermatol. (2003) [Pubmed]
  24. Human type I cytokeratin genes are a compact cluster. Ceratto, N., Dobkin, C., Carter, M., Jenkins, E., Yao, X.L., Cassiman, J.J., Aly, M.S., Bosco, P., Leube, R., Langbein, L., Feo, S., Romano, V. Cytogenet. Cell Genet. (1997) [Pubmed]
  25. In situ hybridization study of cytokeratin 4, 13, 16 and 19 mRNAs in human developing junctional epithelium. Feghali-Assaly, M., Sawaf, M.H., Ouhayoun, J.P. Eur. J. Oral Sci. (1997) [Pubmed]
  26. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. Kuruc, N., Leube, R.E., Moll, I., Bader, B.L., Franke, W.W. Differentiation (1989) [Pubmed]
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