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Bmp4  -  bone morphogenetic protein 4

Rattus norvegicus

Synonyms: BMP-2B, BMP-4, Bmp-4, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, ...
 
 
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Disease relevance of Bmp4

 

High impact information on Bmp4

 

Biological context of Bmp4

 

Anatomical context of Bmp4

 

Associations of Bmp4 with chemical compounds

 

Regulatory relationships of Bmp4

  • BMP-2 and BMP-6 also inhibited BMP-4 mRNA levels [12].
  • In cerebellar cultures prepared at P6 or P10, BMP4 activates Smad1 signaling to modulate cell differentiation [20].
  • We show that during the initial appearance and subsequent maturation of OPCs, BMP4 was expressed specifically in the dorsal midline and its expression was correlated spatially and temporally with phospho-Smad 1+, BMP4-responsive cells [14].
 

Other interactions of Bmp4

  • BMP-2 showed reduced potency compared to either BMP-4 or -6 [21].
  • During the inflammatory response on day 1, slightly increased expression of BMP-3, BMP-4, BMP-R1a, and BMP-R2 was observed, with immunostaining seen among inflammatory cells at the injury site [22].
  • Transforming growth factor beta1 increased, whereas fibroblast growth factor-2, platelet-derived growth factor BB, and insulin-like growth factor I decreased BMP-4 mRNA in Ob cells [12].
  • Whereas, cell bodies remained rounded in control medium or with only BMPs present, addition of BMP4 or BMP6 robustly increased the neuritogenic effect of NGF within 2 days [15].
  • In dissociated cell cultures of embryonic rat spinal cord, Shh and BMP4 had antagonistic effects on OPC development and the sensitivity of oligodendrocyte lineage cells to BMP4 increased with maturation [14].
 

Analytical, diagnostic and therapeutic context of Bmp4

References

  1. Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo. Lin, L., Fu, X., Zhang, X., Chen, L.X., Zhang, J.Y., Yu, C.L., Ma, K.T., Zhou, C.Y. Acta Pharmacol. Sin. (2006) [Pubmed]
  2. Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture. Yaoita, H., Orimo, H., Shirai, Y., Shimada, T. J. Bone Miner. Metab. (2000) [Pubmed]
  3. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda, M., Giacomini, D., Refojo, D., Nagashima, A.C., Hopfner, U., Grubler, Y., Chervin, A., Goldberg, V., Goya, R., Hentges, S.T., Low, M.J., Holsboer, F., Stalla, G.K., Arzt, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. The role of cell type in bone healing mediated by ex vivo gene therapy. Rose, T., Peng, H., Shen, H.C., Usas, A., Kuroda, R., Lill, H., Fu, F.H., Huard, J. Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie. (2003) [Pubmed]
  5. Expression and purification of biologically active rat bone morphogenetic protein-4 produced as inclusion bodies in recombinant Escherichia coli. Klösch, B., Fürst, W., Kneidinger, R., Schuller, M., Rupp, B., Banerjee, A., Redl, H. Biotechnol. Lett. (2005) [Pubmed]
  6. A functional bone morphogenetic protein system in the ovary. Shimasaki, S., Zachow, R.J., Li, D., Kim, H., Iemura, S., Ueno, N., Sampath, K., Chang, R.J., Erickson, G.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Fang, J., Zhu, Y.Y., Smiley, E., Bonadio, J., Rouleau, J.P., Goldstein, S.A., McCauley, L.K., Davidson, B.L., Roessler, B.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression. Kiyono, M., Shibuya, M. Mol. Cell. Biol. (2003) [Pubmed]
  9. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. Kalyani, A.J., Piper, D., Mujtaba, T., Lucero, M.T., Rao, M.S. J. Neurosci. (1998) [Pubmed]
  10. Spatial and temporal patterns of expression of Noggin and BMP4 in embryonic and postnatal rat hippocampus. Fan, X., Xu, H., Cai, W., Yang, Z., Zhang, J. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  11. Cloning and sequence of bone morphogenetic protein 4 cDNA from fetal rat calvarial cell. Chen, D., Feng, J.Q., Feng, M., Harris, M.A., Mundy, G.R., Harris, S.E. Biochim. Biophys. Acta (1993) [Pubmed]
  12. Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts. Pereira, R.C., Rydziel, S., Canalis, E. J. Cell. Physiol. (2000) [Pubmed]
  13. Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4. Shen, H.C., Peng, H., Usas, A., Gearhart, B., Fu, F.H., Huard, J. The journal of gene medicine. (2004) [Pubmed]
  14. Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4. Miller, R.H., Dinsio, K., Wang, R., Geertman, R., Maier, C.E., Hall, A.K. J. Neurosci. Res. (2004) [Pubmed]
  15. Bone morphogenetic protein signalling in NGF-stimulated PC12 cells. Althini, S., Usoskin, D., Kylberg, A., ten Dijke, P., Ebendal, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  16. Developmental abnormalities in rat embryos leading to tibial ray deficiencies induced by busulfan. Otsuji, M., Takahara, M., Naruse, T., Guan, D., Harada, M., Zhe, P., Takagi, M., Ogino, T. Birth defects research. Part A, Clinical and molecular teratology. (2005) [Pubmed]
  17. Converse relationship between in vitro osteogenic differentiation and in vivo bone healing elicited by different populations of muscle-derived cells genetically engineered to express BMP4. Peng, H., Usas, A., Gearhart, B., Olshanski, A., Shen, H.C., Huard, J. J. Bone Miner. Res. (2004) [Pubmed]
  18. Identification of new thyroid hormone-regulated genes in rat brain neuronal cultures. Martel, J., Cayrou, C., Puymirat, J. Neuroreport (2002) [Pubmed]
  19. The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function. Gregori, N., Pröschel, C., Noble, M., Mayer-Pröschel, M. J. Neurosci. (2002) [Pubmed]
  20. Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. Angley, C., Kumar, M., Dinsio, K.J., Hall, A.K., Siegel, R.E. J. Neurosci. (2003) [Pubmed]
  21. The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro. Hughes, F.J., Collyer, J., Stanfield, M., Goodman, S.A. Endocrinology (1995) [Pubmed]
  22. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo, T.Q., Scherer, M.A., Zhou, F.H., Foster, B.K., Xian, C.J. J. Histochem. Cytochem. (2006) [Pubmed]
  23. Enhancement of fibronectin synthesis and fibrillogenesis by BMP-4 in cultured rat osteoblast. Tang, C.H., Yang, R.S., Liou, H.C., Fu, W.M. J. Bone Miner. Res. (2003) [Pubmed]
 
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