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Gene Review

Gdnf  -  glial cell derived neurotrophic factor

Rattus norvegicus

Synonyms: ATF, Astrocyte-derived trophic factor, Glial cell line-derived neurotrophic factor
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  1. Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Harada, C., Harada, T., Quah, H.M., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L.F., Tanaka, K. Neuroscience (2003) [Pubmed]
  2. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. Nosheny, R.L., Bachis, A., Aden, S.A., De Bernardi, M.A., Mocchetti, I. J. Neurobiol. (2006) [Pubmed]
  3. Glial cell line-derived neurotrophic factor and nerve growth factor receptor mRNAs are expressed in distinct subgroups of dorsal root ganglion neurons and are differentially regulated by peripheral axotomy in the rat. Kashiba, H., Hyon, B., Senba, E. Neurosci. Lett. (1998) [Pubmed]
  4. Synaptic targeting of retrogradely transported trophic factors in motoneurons: comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin. Rind, H.B., Butowt, R., von Bartheld, C.S. J. Neurosci. (2005) [Pubmed]
  5. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Tümer, N., Scarpace, P.J., Dogan, M.D., Broxson, C.S., Matheny, M., Yurek, D.M., Peden, C.S., Burger, C., Muzyczka, N., Mandel, R.J. Neurobiol. Aging (2006) [Pubmed]
  6. Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Araujo, D.M., Hilt, D.C. Neuroscience (1997) [Pubmed]
  7. Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats. Lapchak, P.A., Miller, P.J., Jiao, S. Neuroscience (1997) [Pubmed]
  8. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Beck, K.D., Valverde, J., Alexi, T., Poulsen, K., Moffat, B., Vandlen, R.A., Rosenthal, A., Hefti, F. Nature (1995) [Pubmed]
  9. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Lin, L.F., Doherty, D.H., Lile, J.D., Bektesh, S., Collins, F. Science (1993) [Pubmed]
  10. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. Dezawa, M., Kanno, H., Hoshino, M., Cho, H., Matsumoto, N., Itokazu, Y., Tajima, N., Yamada, H., Sawada, H., Ishikawa, H., Mimura, T., Kitada, M., Suzuki, Y., Ide, C. J. Clin. Invest. (2004) [Pubmed]
  11. Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Kruger, G.M., Mosher, J.T., Tsai, Y.H., Yeager, K.J., Iwashita, T., Gariepy, C.E., Morrison, S.J. Neuron (2003) [Pubmed]
  12. TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. Krieglstein, K., Suter-Crazzolara, C., Fischer, W.H., Unsicker, K. EMBO J. (1995) [Pubmed]
  13. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. Skaper, S.D., Kee, W.J., Facci, L., Macdonald, G., Doherty, P., Walsh, F.S. J. Neurochem. (2000) [Pubmed]
  14. Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro. Eggert, K., Schlegel, J., Oertel, W., Würz, C., Krieg, J.C., Vedder, H. Neurosci. Lett. (1999) [Pubmed]
  15. Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells. Shao, Z., Dyck, L.E., Wang, H., Li, X.M. Journal of psychiatry & neuroscience : JPN. (2006) [Pubmed]
  16. Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets. Kholodilov, N., Yarygina, O., Oo, T.F., Zhang, H., Sulzer, D., Dauer, W., Burke, R.E. J. Neurosci. (2004) [Pubmed]
  17. Expression of Ret receptor tyrosine kinase after transient forebrain ischemia is modulated by glial cell line-derived neurotrophic factor in rat hippocampus. Miyazaki, H., Nagashima, K., Okuma, Y., Nomura, Y. Neurosci. Lett. (2002) [Pubmed]
  18. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. Trupp, M., Belluardo, N., Funakoshi, H., Ibáñez, C.F. J. Neurosci. (1997) [Pubmed]
  19. Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Boyd, J.G., Gordon, T. Exp. Neurol. (2003) [Pubmed]
  20. Upregulation of glial cell line-derived neurotrophic factor and artemin mRNA in the auditory nerve of deafened rats. Wissel, K., Wefstaedt, P., Rieger, H., Miller, J.M., Lenarz, T., Stöver, T. Neuroreport (2006) [Pubmed]
  21. Activation of cell-survival signal Akt by GDNF in normal rat brain. Jin, G., Omori, N., Li, F., Sato, K., Nagano, I., Manabe, Y., Shoji, M., Abe, K. Brain Res. (2002) [Pubmed]
  22. Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo. Oo, T.F., Kholodilov, N., Burke, R.E. J. Neurosci. (2003) [Pubmed]
  23. Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Chao, C.C., Ma, Y.L., Chu, K.Y., Lee, E.H. Neurobiol. Aging (2003) [Pubmed]
  24. Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells. Iwase, T., Jung, C.G., Bae, H., Zhang, M., Soliven, B. J. Neurochem. (2005) [Pubmed]
  25. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF). Yan, Q., Wang, J., Matheson, C.R., Urich, J.L. J. Neurobiol. (1999) [Pubmed]
  26. Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system. Glazner, G.W., Mu, X., Springer, J.E. J. Comp. Neurol. (1998) [Pubmed]
  27. Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease. Pérez-Navarro, E., Akerud, P., Marco, S., Canals, J.M., Tolosa, E., Arenas, E., Alberch, J. Neuroscience (2000) [Pubmed]
  28. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Sajadi, A., Bauer, M., Thöny, B., Aebischer, P. J. Neurochem. (2005) [Pubmed]
  29. Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells. Armstrong, K.J., Niles, L.P. Neuroreport (2002) [Pubmed]
  30. Expression of GFR alpha-1, GFR alpha-2, and c-Ret mRNAs in rat adrenal gland. Schober, A., Arumäe, U., Saarma, M., Unsicker, K. J. Neurocytol. (2000) [Pubmed]
  31. Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons. Feng, L., Wang, C.Y., Jiang, H., Oho, C., Dugich-Djordjevic, M., Mei, L., Lu, B. Neuroscience (1999) [Pubmed]
  32. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. Trupp, M., Scott, R., Whittemore, S.R., Ibáñez, C.F. J. Biol. Chem. (1999) [Pubmed]
  33. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. Vellani, V., Colucci, M., Lattanzi, R., Giannini, E., Negri, L., Melchiorri, P., McNaughton, P.A. J. Neurosci. (2006) [Pubmed]
  34. Glial cell line-derived neurotrophic factor stimulates the morphological differentiation of cultured ventral mesencephalic calbindin- and calretinin-expressing neurons. Widmer, H.R., Schaller, B., Meyer, M., Seiler, R.W. Exp. Neurol. (2000) [Pubmed]
  35. Glial cell line-derived neurotrophic factor promotes the arborization of cultured striatal neurons through the p42/p44 mitogen-activated protein kinase pathway. García-Martínez, J.M., Pérez-Navarro, E., Gavaldà, N., Alberch, J. J. Neurosci. Res. (2006) [Pubmed]
  36. Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones. Bauer, M., Suppmann, S., Meyer, M., Hesslinger, C., Gasser, T., Widmer, H.R., Ueffing, M. J. Neurochem. (2002) [Pubmed]
  37. Glial cell line-derived neurotrophic factor modulates ischemia-induced tyrosine hydroxylase expression in rat hippocampus. Miyazaki, H., Ono, T., Okuma, Y., Nagashima, K., Nomura, Y. Eur. J. Neurosci. (2000) [Pubmed]
  38. Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2. Garcès, A., Livet, J., Grillet, N., Henderson, C.E., Delapeyrière, O. Dev. Dyn. (2001) [Pubmed]
  39. Additivity and potentiation of IGF-I and GDNF in the complete rescue of postnatal motor neurons. Bilak, M.M., Corse, A.M., Kuncl, R.W. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2001) [Pubmed]
  40. Alterations in expression of the neurotrophic factors glial cell line-derived neurotrophic factor, ciliary neurotrophic factor and brain-derived neurotrophic factor, in the target-deprived olfactory neuroepithelium. Buckland, M.E., Cunningham, A.M. Neuroscience (1999) [Pubmed]
  41. Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors. Woodhall, E., West, A.K., Chuah, M.I. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  42. cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Springer, J.E., Seeburger, J.L., He, J., Gabrea, A., Blankenhorn, E.P., Bergman, L.W. Exp. Neurol. (1995) [Pubmed]
  43. Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Gao, J., Prough, D.S., McAdoo, D.J., Grady, J.J., Parsley, M.O., Ma, L., Tarensenko, Y.I., Wu, P. Exp. Neurol. (2006) [Pubmed]
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