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Gene Review

Slc20a2  -  solute carrier family 20 (phosphate...

Rattus norvegicus

Synonyms: Ab1-188, Glvr2, Phosphate transporter 2, PiT-2, Pit-2, ...
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Disease relevance of Slc20a2

  • We have identified the cellular receptor for amphotropic murine retroviruses, Ram-1, by screening a rat cDNA expression library introduced into amphotropic virus-resistant hamster cells [1].
  • Furthermore, we have constructed Ram-1/Glvr-1 hybrid receptors that allow entry of both GALV and amphotropic virus [2].

High impact information on Slc20a2

  • Phosphate uptake was reduced by > 50% in mouse fibroblasts expressing amphotropic envelope glycoprotein, which binds to Ram-1, indicating that Ram-1 is a major phosphate transporter in these cells [3].
  • CHO cells express the hamster homolog of Ram-1 but are resistant to amphotropic retroviruses [4].
  • The induction of Glvr-2 mRNA by Pi was inhibited in the presence of cycloheximide (CHX) [5].
  • These data indicate that extracellular Pi regulates Glvr-2 mRNA expression, provide insights into possible mechanisms whereby Pi may regulate protein phosphorylation, and suggest a potential role for the Pi transporter in rat bone marrow stromal cells [5].
  • On the other hand, there was near absence of gene transfer in untreated rats perfused with rMoMuLV Twenty-four hours after the initial manipulation, abundant expression of Ram-1 mRNA was observed in rat hepatocytes treated with HGF plus T3 [6].

Chemical compound and disease context of Slc20a2

  • Our data also reveal that other known Na+/P(i) cotransporter genes, NaPi-2 and Ram-1 (a receptor for amphotropic murine retrovirus), are not regulated by insulin and glucose [7].

Biological context of Slc20a2


Anatomical context of Slc20a2


Associations of Slc20a2 with chemical compounds

  • We tested the effects of extracellular Pi, Ca(2+) and IGF-I on Na(d)Pi transport and Pit-1 or Pit-2 mRNA expression in rat osteoblastic (PyMS) cells [8].

Analytical, diagnostic and therapeutic context of Slc20a2

  • The amphotropic retroviral receptor (Ram-1) expression of liver was evaluated at different time points after injecting HGF and T3 by means of Northern blotting using Ram-1 cDNA probe [6].


  1. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Miller, D.G., Edwards, R.H., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. A family of retroviruses that utilize related phosphate transporters for cell entry. Miller, D.G., Miller, A.D. J. Virol. (1994) [Pubmed]
  3. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Kavanaugh, M.P., Miller, D.G., Zhang, W., Law, W., Kozak, S.L., Kabat, D., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species. Kozak, S.L., Siess, D.C., Kavanaugh, M.P., Miller, A.D., Kabat, D. J. Virol. (1995) [Pubmed]
  5. Extracellular inorganic phosphate regulates gibbon ape leukemia virus receptor-2/phosphate transporter mRNA expression in rat bone marrow stromal cells. Wada, K., Mizuno, M., Komori, T., Tamura, M. J. Cell. Physiol. (2004) [Pubmed]
  6. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. Minami, H., Tada, K., Chowdhury, N.R., Chowdhury, J.R., Onji, M. J. Hepatol. (2000) [Pubmed]
  7. Regulation of rat Na+/Pi cotransporter-1 gene expression: the roles of glucose and insulin. Li, H., Ren, P., Onwochei, M., Ruch, R.J., Xie, Z. Am. J. Physiol. (1996) [Pubmed]
  8. Regulation of phosphate (Pi) transport and NaPi-III transporter (Pit-1) mRNA in rat osteoblasts. Zoidis, E., Ghirlanda-Keller, C., Gosteli-Peter, M., Zapf, J., Schmid, C. J. Endocrinol. (2004) [Pubmed]
  9. Lack of functional Pit-1 and Pit-2 expression on hematopoietic stem cell lines. Thomsen, S., Vogt, B., von Laer, D., Heberlein, C., Rein, A., Ostertag, W., Stocking, C. Acta Haematol. (1998) [Pubmed]
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