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Gene Review

ANAPC2  -  anaphase promoting complex subunit 2

Homo sapiens

Synonyms: APC2, Anaphase-promoting complex subunit 2, Cyclosome subunit 2, KIAA1406
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Disease relevance of ANAPC2

  • We have fine mapped APC2 to a small region of chromosome 19p13.3 containing markers D19S883 and WI-19632, a region commonly lost in a variety of cancers, particularly ovarian cancer [1].
  • Severe adverse events included APC 2/13 (15%) stricture, 1/13 (8%) odynophagia, chest pain and fever; PDT 2/13 (15%) photosensitivity, 2/13 (15%) stricture [2].

High impact information on ANAPC2


Biological context of ANAPC2

  • However, the minimal APC2/11 ubiquitin ligase module does not possess substrate specificity, because it also ubiquitinates the destruction box deletion mutants of securin and cyclin B1 [4].
  • Altogether, APC2 have come to age; they mediate Th2 differentiation, tolerance induction, downregulation of inflammation and healing [5].
  • Macrophages (M phi) as well as dendritic cells (DCs) can undergo Th1- or Th2-like polarization; APC1 and APC2 thus acquire the capacity to drive the development of naive T cells and the reactivation of resting T cells towards either a Th1 or a Th2 phenotype, respectively [5].

Anatomical context of ANAPC2


Associations of ANAPC2 with chemical compounds

  • Antibodies against the NH2 terminus of human APC2 show that endogenous APC2 is diffusely distributed in the cytoplasm and colocalizes with both the Golgi apparatus and actin filaments [1].

Other interactions of ANAPC2

  • APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex [4].


  1. Human APC2 localization and allelic imbalance. Jarrett, C.R., Blancato, J., Cao, T., Bressette, D.S., Cepeda, M., Young, P.E., King, C.R., Byers, S.W. Cancer Res. (2001) [Pubmed]
  2. Endoscopic ablation of dysplastic Barrett's oesophagus comparing argon plasma coagulation and photodynamic therapy: a randomized prospective trial assessing efficacy and cost-effectiveness. Ragunath, K., Krasner, N., Raman, V.S., Haqqani, M.T., Phillips, C.J., Cheung, I. Scand. J. Gastroenterol. (2005) [Pubmed]
  3. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Yu, H., Peters, J.M., King, R.W., Page, A.M., Hieter, P., Kirschner, M.W. Science (1998) [Pubmed]
  4. APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Ozkan, E., Hakala, K., Deisenhofer, J., Yu, H. Mol. Biol. Cell (2001) [Pubmed]
  5. Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing. Gratchev, A., Schledzewski, K., Guillot, P., Goerdt, S. Skin Pharmacol. Appl. Skin Physiol. (2001) [Pubmed]
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