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Gene Review

DNMT3L  -  DNA (cytosine-5-)-methyltransferase 3-like

Homo sapiens

Synonyms: DNA (cytosine-5)-methyltransferase 3-like, MGC1090
 
 
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Disease relevance of DNMT3L

 

High impact information on DNMT3L

 

Biological context of DNMT3L

  • Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L [3].
  • Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting [4].
  • Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family [5].
  • Significantly, whilst the murine Dnmt3L gene is both expressed and essential for imprint establishment during murine oogenesis, transcripts of the human DNMT3L gene were only detected after fertilisation [6].
 

Anatomical context of DNMT3L

 

Associations of DNMT3L with chemical compounds

 

Physical interactions of DNMT3L

  • Here we show that DNMT3L can also repress transcription by binding directly to HDAC1 protein [7].
 

Other interactions of DNMT3L

References

  1. DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. Minami, K., Chano, T., Kawakami, T., Ushida, H., Kushima, R., Okabe, H., Okada, Y., Okamoto, K. Clin. Cancer Res. (2010) [Pubmed]
  2. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Chedin, F., Lieber, M.R., Hsieh, C.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. Kareta, M.S., Botello, Z.M., Ennis, J.J., Chou, C., Chédin, F. J. Biol. Chem. (2006) [Pubmed]
  4. Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting. Yokomine, T., Hata, K., Tsudzuki, M., Sasaki, H. Cytogenet. Genome Res. (2006) [Pubmed]
  5. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. Aapola, U., Kawasaki, K., Scott, H.S., Ollila, J., Vihinen, M., Heino, M., Shintani, A., Kawasaki, K., Minoshima, S., Krohn, K., Antonarakis, S.E., Shimizu, N., Kudoh, J., Peterson, P. Genomics (2000) [Pubmed]
  6. Expression of mRNAs for DNA methyltransferases and methyl-CpG-binding proteins in the human female germ line, preimplantation embryos, and embryonic stem cells. Huntriss, J., Hinkins, M., Oliver, B., Harris, S.E., Beazley, J.C., Rutherford, A.J., Gosden, R.G., Lanzendorf, S.E., Picton, H.M. Mol. Reprod. Dev. (2004) [Pubmed]
  7. Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Aapola, U., Liiv, I., Peterson, P. Nucleic Acids Res. (2002) [Pubmed]
 
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