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Nfat5  -  nuclear factor of activated T-cells 5,...

Rattus norvegicus

Synonyms: NF-AT5, Nfat, Nuclear factor of activated T-cells 5, T-cell transcription factor NFAT5, TonEBP
 
 
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Disease relevance of Nfat5_predicted

  • For investigating regulation of TonEBP in the kidney, rats were subjected to water loading or dehydration [1].
 

High impact information on Nfat5_predicted

  • The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression [2].
  • Tonicity responsive enhancer binding protein (TonEBP) is the transcription factor that regulates tonicity responsive expression of proteins that catalyze cellular accumulation of compatible osmolytes [1].
  • Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression [1].
  • Notable exceptions were the middle to terminal portions of the inner medullary collecting ducts and blood vessels, where a change in TonEBP distribution was not evident [1].
  • In embryonic kidneys, TonEBP immunoreactivity was detected 16 days postcoitus in the cytoplasm of the endothelial cells surrounding the medullary collecting ducts (MCD) [3].
 

Biological context of Nfat5_predicted

 

Anatomical context of Nfat5_predicted

  • The conclusions are as follows: 1) TonEBP protein or mRNA expression is reduced by hyposmolality in thymus, liver, and brain [5].
  • By 20 days, TonEBP was detected in most tubular profiles in the medulla, including the loop of Henle and MCD, and interstitial cells [3].
  • In rats subjected to prolonged systemic hypertonicity, TonEBP labeling increased in the cell nuclei of neurons only [4].
  • Nevertheless these non-neuronal TonEBP-positive nuclei which belonged to oligodendrocytes and to a small subpopulation of astrocytes remained always very weakly labeled when compared with neuron nuclei [6].
 

Associations of Nfat5_predicted with chemical compounds

  • In the renal medulla, TonEBP stimulates genes encoding proteins involved in cellular accumulation of organic osmolytes, the vasopressin-regulated urea transporters (UT-A), and heat shock protein 70 [3].
 

Physical interactions of Nfat5_predicted

  • Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain [6].
 

Other interactions of Nfat5_predicted

 

Analytical, diagnostic and therapeutic context of Nfat5_predicted

  • We measured TonEBP mRNA (real-time PCR) and protein (Western blot analysis) in tissues of control (plasma osmolality 294 +/- 1 mosmol/kgH2O) and hyposmotic (dDAVP infusion plus water loading for 3 days, 241 +/- 2 mosmol/kgH2O) rats to test whether the ubiquitous expression of TonEBP mRNA is osmotically regulated around the normal plasma osmolality [5].
  • In normal rats, TonEBP immunolabeling and TonEBP-mRNA in situ hybridization labeling showed a widespread, uneven and parallel distribution [4].
  • TonEBP-expressing cells were identified using double immunofluorescence and appropriate cell type markers [6].

References

  1. Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney. Cha, J.H., Woo, S.K., Han, K.H., Kim, Y.H., Handler, J.S., Kim, J., Kwon, H.M. J. Am. Soc. Nephrol. (2001) [Pubmed]
  2. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. Nakayama, Y., Peng, T., Sands, J.M., Bagnasco, S.M. J. Biol. Chem. (2000) [Pubmed]
  3. Maturation of TonEBP expression in developing rat kidney. Han, K.H., Woo, S.K., Kim, W.Y., Park, S.H., Cha, J.H., Kim, J., Kwon, H.M. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  4. Differential cellular distribution of tonicity-induced expression of transcription factor TonEBP in the rat brain following prolonged systemic hypertonicity. Maallem, S., Mutin, M., Kwon, H.M., Tappaz, M.L. Neuroscience (2006) [Pubmed]
  5. Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. Zhang, Z., Ferraris, J.D., Brooks, H.L., Brisc, I., Burg, M.B. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  6. Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Loyher, M.L., Mutin, M., Woo, S.K., Kwon, H.M., Tappaz, M.L. Neuroscience (2004) [Pubmed]
 
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