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Gene Review

Dok1  -  docking protein 1

Rattus norvegicus

Synonyms: Docking protein 1, Downstream of tyrosine kinase 1
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High impact information on Dok1


Biological context of Dok1


Anatomical context of Dok1


Associations of Dok1 with chemical compounds

  • These findings identify Dok-1 as mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators [5].
  • The negative regulatory role of Dok-1 was further validated by the expression of small interfering RNA directed against Dok-1, which enhanced activation of MAP kinase and subsequent release of arachidonic acid and tumor necrosis factor-alpha [5].

Enzymatic interactions of Dok1


Other interactions of Dok1


  1. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Liu, F., Sells, M.A., Chernoff, J. Mol. Cell. Biol. (1998) [Pubmed]
  2. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. Huang, J., Hamasaki, H., Nakamoto, T., Honda, H., Hirai, H., Saito, M., Takato, T., Sakai, R. J. Biol. Chem. (2002) [Pubmed]
  3. Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis. Nehrbass, D., Klimek, F., Bannasch, P. Am. J. Pathol. (1998) [Pubmed]
  4. Platelet-derived growth factor stimulates growth factor receptor binding protein-2 association with Shc in vascular smooth muscle cells. Benjamin, C.W., Jones, D.A. J. Biol. Chem. (1994) [Pubmed]
  5. Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Hiragun, T., Peng, Z., Beaven, M.A. Mol. Pharmacol. (2005) [Pubmed]
  6. Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor. Abramson, J., Rozenblum, G., Pecht, I. Eur. J. Immunol. (2003) [Pubmed]
  7. G protein-coupled receptor agonist-stimulated expression of ATF3/LRF-1 and c-myc and comitogenic effects in hepatocytes do not require EGF receptor transactivation. Nilssen, L.S., Odegård, J., Thoresen, G.H., Molven, A., Sandnes, D., Christoffersen, T. J. Cell. Physiol. (2004) [Pubmed]
  8. Immunochemical analysis of rough and smooth microsomes from rat liver. Segregation of docking protein in rough membranes. Hortsch, M., Meyer, D.I. Eur. J. Biochem. (1985) [Pubmed]
  9. Restriction of docking protein to the rough endoplasmic reticulum: immunocytochemical localization in rat liver. Hortsch, M., Griffiths, G., Meyer, D.I. Eur. J. Cell Biol. (1985) [Pubmed]
  10. Organization of functional domains in the docking protein p130Cas. Nasertorabi, F., Garcia-Guzman, M., Briknarová, K., Larsen, E., Havert, M.L., Vuori, K., Ely, K.R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by oxidant stress in cerebellar granule neurons: modulation by N-methyl-D-aspartate through calcineurin activity. Hallak, H., Ramadan, B., Rubin, R. J. Neurochem. (2001) [Pubmed]
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