Gene Review:
Bcar1 - breast cancer anti-estrogen resistance 1
Rattus norvegicus
Synonyms:
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas, Crkas, P130CAS, ...
- Organization of functional domains in the docking protein p130Cas. Nasertorabi, F., Garcia-Guzman, M., Briknarová, K., Larsen, E., Havert, M.L., Vuori, K., Ely, K.R. Biochem. Biophys. Res. Commun. (2004)
- p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts. Honda, H., Nakamoto, T., Sakai, R., Hirai, H. Biochem. Biophys. Res. Commun. (1999)
- Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. Minegishi, M., Tachibana, K., Sato, T., Iwata, S., Nojima, Y., Morimoto, C. J. Exp. Med. (1996)
- A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. Sakai, R., Iwamatsu, A., Hirano, N., Ogawa, S., Tanaka, T., Mano, H., Yazaki, Y., Hirai, H. EMBO J. (1994)
- Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation. Yano, H., Uchida, H., Iwasaki, T., Mukai, M., Akedo, H., Nakamura, K., Hashimoto, S., Sabe, H. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Vuori, K., Hirai, H., Aizawa, S., Ruoslahti, E. Mol. Cell. Biol. (1996)
- Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate. Huang, J., Hamasaki, H., Nakamoto, T., Honda, H., Hirai, H., Saito, M., Takato, T., Sakai, R. J. Biol. Chem. (2002)
- Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells. Hoon Kim, D., Jeon Choi, S., Kook, S., Kim, W., Keun Song, W. Biochem. Biophys. Res. Commun. (2003)
- Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. Nojima, Y., Morino, N., Mimura, T., Hamasaki, K., Furuya, H., Sakai, R., Sato, T., Tachibana, K., Morimoto, C., Yazaki, Y. J. Biol. Chem. (1995)
- Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions. Pellicena, P., Miller, W.T. J. Biol. Chem. (2001)
- The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. Briknarová, K., Nasertorabi, F., Havert, M.L., Eggleston, E., Hoyt, D.W., Li, C., Olson, A.J., Vuori, K., Ely, K.R. J. Biol. Chem. (2005)
- Glucose stimulates the tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells. Konrad, R.J., Gold, G., Lee, T.N., Workman, R., Broderick, C.L., Knierman, M.D. J. Biol. Chem. (2003)
- Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Kovacic-Milivojević, B., Roediger, F., Almeida, E.A., Damsky, C.H., Gardner, D.G., Ilić, D. Mol. Biol. Cell (2001)
- SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. Dail, M., Kalo, M.S., Seddon, J.A., Côté, J.F., Vuori, K., Pasquale, E.B. J. Biol. Chem. (2004)
- Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation. Kyaw, M., Yoshizumi, M., Tsuchiya, K., Kagami, S., Izawa, Y., Fujita, Y., Ali, N., Kanematsu, Y., Toida, K., Ishimura, K., Tamaki, T. Mol. Pharmacol. (2004)
- Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Liu, F., Sells, M.A., Chernoff, J. Curr. Biol. (1998)
- A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction. Ogden, K., Thompson, J.M., Hickner, Z., Huang, T., Tang, D.D., Watts, S.W. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells. Kook, S., Shim, S.R., Choi, S.J., Ahnn, J., Kim, J.I., Eom, S.H., Jung, Y.K., Paik, S.G., Song, W.K. Mol. Biol. Cell (2000)
- Reduction of tyrosine-phosphorylated proteins in involuted thymuses of stressed rats: a study using immunological methods. Nishio, H., Tsuji, H., Tamura, A., Suzuki, K. Electrophoresis (2000)