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Gene Review

MuHV1_gp092  -  UL99 (pp28)

Murid herpesvirus 1

 
 
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Disease relevance of MuHV1gpM99

 

High impact information on MuHV1gpM99

 

Biological context of MuHV1gpM99

 

Anatomical context of MuHV1gpM99

  • Presence of AM3/pp50 mRNA, as well as IE-1 transcripts, was confirmed by reverse transcription-polymerase chain reaction in 3 of 5 latently infected spleens [11].
  • During transient expression of pp50 in COS-1 cells, the phosphoprotein was readily detectable in the nuclei, indicating that it possesses a nuclear localization signal (NLS) [12].
  • Similarly, during MCMV infection of Balb/3T3 fibroblasts, pp50 was present in the nuclei of infected cells between 8 and 24 hr postinfection, suggesting that the protein contains a functional nuclear targeting sequence [4].
  • We have identified an abundant 50K phosphoprotein (pp50) in MCMV-infected 3T3-L1 cells and shown by immunofluorescence microscopy and surface-iodination experiments that pp50 is localized to the plasma membrane of the infected cell [10].
 

Associations of MuHV1gpM99 with chemical compounds

  • Finally, results from our analysis by nonreducing and native gel electrophoresis, as well as fractionation by sucrose gradients suggested that pp50 expressed in the absence of viral infection can form disulfide-linked homopolymers [4].
 

Analytical, diagnostic and therapeutic context of MuHV1gpM99

References

  1. Cloning, characterization, and expression of the murine cytomegalovirus homologue of the human cytomegalovirus 28-kDa matrix phosphoprotein (UL99). Cranmer, L.D., Clark, C., Spector, D.H. Virology (1994) [Pubmed]
  2. Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65). Morello, C.S., Cranmer, L.D., Spector, D.H. J. Virol. (2000) [Pubmed]
  3. In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83). Morello, C.S., Cranmer, L.D., Spector, D.H. J. Virol. (1999) [Pubmed]
  4. Sequence analysis and expression of the murine cytomegalovirus phosphoprotein pp50, a homolog of the human cytomegalovirus UL44 gene product. Loh, L.C., Britt, W.J., Raggo, C., Laferté, S. Virology (1994) [Pubmed]
  5. Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase. Del Val, M., Münch, K., Reddehase, M.J., Koszinowski, U.H. Cell (1989) [Pubmed]
  6. DNA immunization confers protection against murine cytomegalovirus infection. González Armas, J.C., Morello, C.S., Cranmer, L.D., Spector, D.H. J. Virol. (1996) [Pubmed]
  7. The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis. Schickedanz, J., Philipson, L., Ansorge, W., Pepperkok, R., Klein, R., Koszinowski, U.H. J. Virol. (1988) [Pubmed]
  8. The 89,000-Mr murine cytomegalovirus immediate-early protein activates gene transcription. Koszinowski, U.H., Keil, G.M., Volkmer, H., Fibi, M.R., Ebeling-Keil, A., Münch, K. J. Virol. (1986) [Pubmed]
  9. Sequence and structural organization of murine cytomegalovirus immediate-early gene 1. Keil, G.M., Ebeling-Keil, A., Koszinowski, U.H. J. Virol. (1987) [Pubmed]
  10. Characterization of a membrane-associated phosphoprotein of murine cytomegalovirus (pp50) and its immunological cross-reactivity with a human cytomegalovirus protein. Loh, L.C., Balachandran, N., Britt, W.J. Virology (1991) [Pubmed]
  11. Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. Yu, Y., Henry, S.C., Xu, F., Hamilton, J.D. J. Infect. Dis. (1995) [Pubmed]
  12. Sequence requirements for the nuclear localization of the murine cytomegalovirus M44 gene product pp50. Loh, L.C., Keeler, V.D., Shanley, J.D. Virology (1999) [Pubmed]
  13. Immediate-early genes of murine cytomegalovirus: location, transcripts, and translation products. Keil, G.M., Ebeling-Keil, A., Koszinowski, U.H. J. Virol. (1987) [Pubmed]
 
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