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Gene Review

IFNE  -  interferon, epsilon

Homo sapiens

Synonyms: IFN-E, IFN-epsilon, IFNE1, IFNT1, INFE1, ...
 
 
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Disease relevance of IFNE1

 

High impact information on IFNE1

  • We hypothesized that the effectiveness of IFNT on extending corpus luteum (CL) life span in nonpregnant ewes would depend upon the dose and manner of administration and would be correlated with the response in gene expression in endometrium [2].
  • In ruminants, conceptus interferon-tau (IFNT) alters maternal physiology to accommodate a pregnancy [2].
  • Consistent with early elongation of blastocysts, interferon tau (IFNT) protein was about 50-fold greater in uterine flushes from Day 12 in ewes receiving P4 compared with those receiving CO [3].
  • Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin [4].
  • Particularly, differential regulation of genes related to central nervous system by rhIFN-epsilon suggests a role for IFN-epsilon in maintenance of the structure and function of brain [1].
 

Associations of IFNE1 with chemical compounds

  • These results indicate that conceptus IFNT induces both RSAD2 and IFIH1 in a P4-independent manner in the ovine uterine endometrium [5].
 

Analytical, diagnostic and therapeutic context of IFNE1

References

  1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. Peng, F.W., Duan, Z.J., Zheng, L.S., Xie, Z.P., Gao, H.C., Zhang, H., Li, W.P., Hou, Y.D. Protein Expr. Purif. (2007) [Pubmed]
  2. Effect of interferon-tau administration on endometrium of nonpregnant ewes: a comparison with pregnant ewes. Chen, Y., Green, J.A., Antoniou, E., Ealy, A.D., Mathialagan, N., Walker, A.M., Avalle, M.P., Rosenfeld, C.S., Hearne, L.B., Roberts, R.M. Endocrinology (2006) [Pubmed]
  3. Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus. Satterfield, M.C., Bazer, F.W., Spencer, T.E. Biol. Reprod. (2006) [Pubmed]
  4. Characterization of the type I interferon locus and identification of novel genes. Hardy, M.P., Owczarek, C.M., Jermiin, L.S., Ejdebäck, M., Hertzog, P.J. Genomics (2004) [Pubmed]
  5. Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Song, G., Bazer, F.W., Spencer, T.E. Reproduction (2007) [Pubmed]
  6. Molecular Characterization of the Interferon-tau Gene of the Mithun (Bos frontalis). Rajaravindra, K.S., Mitra, A., Sharma, A.K., Deb, S.M., Sharma, A. Zool. Sci. (2006) [Pubmed]
 
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