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Gene Review

RSAD2  -  radical S-adenosyl methionine domain...

Homo sapiens

Synonyms: 2510004L01Rik, CIG5, Cytomegalovirus-induced gene 5 protein, Radical S-adenosyl methionine domain-containing protein 2, Viperin, ...
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Disease relevance of RSAD2


High impact information on RSAD2

  • HCMV infection causes the redistribution of the induced viperin from its normal endoplasmic reticulum association, first to the Golgi apparatus and then to cytoplasmic vacuoles containing gB and pp28 [1].
  • Expression before HCMV infection reduces viperin redistribution from the endoplasmic reticulum to the Golgi apparatus and prevents vacuolar localization, perhaps reflecting the mechanism used by HCMV to evade the antiviral function [1].
  • Stimulation of Huh-7 and HepG2 cells with IFN-alpha or -gamma revealed viperin is predominantly a type I ISG [2].
  • Furthermore, viperin expression could also be induced following transfection of Huh-7 cells with either poly(I:C) or HCV RNA [2].
  • Transient expression of viperin in cells harboring the HCV genomic replicon resulted in a significant decrease in HCV replication, suggesting that viperin has anti-HCV activity [2].

Biological context of RSAD2


Anatomical context of RSAD2

  • Viperin was expressed by endothelial cells in atherosclerotic arteries and significantly elevated in atherosclerotic compared with normal arteries [8].
  • This study tested the hypothesis that RSAD2 and IFIH1 were induced in the endometrium in a cell type-specific manner by IFNT from the conceptus during early pregnancy [6].
  • Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus [6].
  • In pregnant ewes, RSAD2 and IFIH1 mRNAs increased in endometrial glands, and stroma and immune cells, but not in the luminal epithelium [6].
  • Moreover, IRF3-deficient, but not IFNalpha/betaR deficient, macrophages still induced Viperin in response to SV [4].

Associations of RSAD2 with chemical compounds


Regulatory relationships of RSAD2


Analytical, diagnostic and therapeutic context of RSAD2


  1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Chin, K.C., Cresswell, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Helbig, K.J., Lau, D.T., Semendric, L., Harley, H.A., Beard, M.R. Hepatology (2005) [Pubmed]
  3. TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig5. Rivieccio, M.A., Suh, H.S., Zhao, Y., Zhao, M.L., Chin, K.C., Lee, S.C., Brosnan, C.F. J. Immunol. (2006) [Pubmed]
  4. Toll-like receptor-dependent and -independent Viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. Severa, M., Coccia, E.M., Fitzgerald, K.A. J. Biol. Chem. (2006) [Pubmed]
  5. vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. Boudinot, P., Massin, P., Blanco, M., Riffault, S., Benmansour, A. J. Virol. (1999) [Pubmed]
  6. Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus. Song, G., Bazer, F.W., Spencer, T.E. Reproduction (2007) [Pubmed]
  7. Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi. Sun, B.J., Nie, P. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  8. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Olofsson, P.S., Jatta, K., Wågsäter, D., Gredmark, S., Hedin, U., Paulsson-Berne, G., Söderberg-Nauclér, C., Hansson, G.K., Sirsjö, A. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  9. JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets. Verma, S., Ziegler, K., Ananthula, P., Co, J.K., Frisque, R.J., Yanagihara, R., Nerurkar, V.R. Virology (2006) [Pubmed]
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