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IFI35  -  interferon-induced protein 35

Homo sapiens

Synonyms: IFP 35, IFP35, Ifi-35, Interferon-induced 35 kDa protein
 
 
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High impact information on IFI35

  • Partial sequences of the 1A1-3B B-box protein pseudogene and IFP 35, an interferon induced leucine zipper protein, reside within the contig [1].
  • A deletion analysis revealed that Nmi must interact with IFP 35 to prevent its degradation and that the amino terminus of Nmi is required, but not sufficient, for this function [2].
  • Two-dimensional gel analysis indicates that the IFN-induced complex formation correlates with IFP35 dephosphorylation [3].
  • Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35 [3].
  • Sucrose gradient sedimentation and size fractionation showed a shift of Nmi-IFP35 heterodimers toward a heavier fraction (100-200 kDa) in IFN-alpha-treated cells [3].
 

Biological context of IFI35

 

Anatomical context of IFI35

 

Physical interactions of IFI35

  • The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling [5].
 

Regulatory relationships of IFI35

  • Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain [8].
  • IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution [4].
 

Other interactions of IFI35

  • The stabilization of IFP 35 by Nmi may serve to amplify the physiologic effects of IFNs [2].
  • Notable IFP 35 is a unique novel leucine zipper protein in that it lacks a basic domain critical for DNA binding [4].
  • The ratio of Nmi to CKIP-1 determines the stability of IFP35 and control cytokine signaling in a novel mechanism [5].
 

Analytical, diagnostic and therapeutic context of IFI35

  • Nmi and IFP 35 proteins associate into a high molecular mass complex of 300-400 kDa as determined by native gel electrophoresis and gel filtration [2].
  • A combination of immunoprecipitation and immunofluorescence studies of cells transfected with a hemagglutinin epitope-tagged IFP 35 expression construct demonstrated complex formation and co-localization of endogenous and transfected IFP 35 [7].

References

  1. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Smith, T.M., Lee, M.K., Szabo, C.I., Jerome, N., McEuen, M., Taylor, M., Hood, L., King, M.C. Genome Res. (1996) [Pubmed]
  2. Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35. Chen, J., Shpall, R.L., Meyerdierks, A., Hagemeier, M., Böttger, E.C., Naumovski, L. J. Biol. Chem. (2000) [Pubmed]
  3. Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. Zhou, X., Liao, J., Meyerdierks, A., Feng, L., Naumovski, L., Bottger, E.C., Omary, M.B. J. Biol. Chem. (2000) [Pubmed]
  4. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. Bange, F.C., Vogel, U., Flohr, T., Kiekenbeck, M., Denecke, B., Böttger, E.C. J. Biol. Chem. (1994) [Pubmed]
  5. The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Zhang, L., Tang, Y., Tie, Y., Tian, C., Wang, J., Dong, Y., Sun, Z., He, F. Cell. Signal. (2007) [Pubmed]
  6. Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. Chen, J., Naumovski, L. J. Interferon Cytokine Res. (2002) [Pubmed]
  7. A cytoplasmic structure resembling large protein aggregates induced by interferons. Meyerdierks, A., Denecke, B., Rohde, M., Taparowsky, E.J., Böttger, E.C. J. Histochem. Cytochem. (1999) [Pubmed]
  8. Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain. Lee, N.D., Chen, J., Shpall, R.L., Naumovski, L. J. Interferon Cytokine Res. (1999) [Pubmed]
 
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