Disease relevance of noc

• Several larva lethal l(2)35Ba alleles cause both hypertrophy and mislocation of the embryonic supraesophageal ganglion (brain) to the dorsal surface of the embryo [1].

High impact information on noc

• Mutations in the genes paralytic and Scutoid cause olfactory defects, as do mutations in genes encoding products that mediate visual responses [2].
• Consistent with the observed embryonic phenotype, l(2)35Ba/nocA shows a complex embryonic expression pattern which includes the procephalic lobe [1].
• Sequence analysis of two full-length l(2)35Ba/nocA cDNAs with distinct polyadenylation sites shows that they encode the same deduced protein of 537 amino acids with a serine- and threonine-rich N-terminal region, two putative zinc finger motifs near the carboxyl terminus, and several alanine-rich domains [1].
• Indeed, in elB or noc mutants, expanded expression of tracheal branch-specific genes was observed [3].
• These overgrowths depend on Notch activity suggesting that elbow and noc repress a Upd independent role of Notch in driving cell proliferation [4].

Biological context of noc

• The Sco phenotype is thought to result from a position effect at the newly created noc/l(2)br28 junction [5].
• Exchange mapping locates the dominant mutation Scutoid to the right of Adh on chromosome arm 2L of D. melanogaster [5].
• The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation [5].
• The noc gene, as defined by the mapping of nearly 30 breakpoints, is at least 50 X 10(3) base-pairs in size [6].

Anatomical context of noc

• These findings suggest the involvement of Sco in an olfactory pathway in adults which is specific for short-chain acetate esters and ketones [7].

Associations of noc with chemical compounds

• Scutoid mutation of Drosophila melanogaster specifically decreases olfactory responses to short-chain acetate esters and ketones [7].
• Sco adults had an impaired behavioral response to EtAC but not to banana or propionate [7].
• Two independent lines of research led to the finding that the dominant Scutoid (Sco) mutation causes a diminished extracellular electroantennogram response to the odorants ethyl acetate (EtAC) and acetone (AC) [7].

Regulatory relationships of noc

• The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VI. Induced revertants of scutoid [8].

Other interactions of noc

• It consists of three discrete genetic regions el, l(2)35Ba and noc, each of which has a distinct phenotype when mutant [9].

References