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Gene Review

AQP6  -  aquaporin 6, kidney specific

Homo sapiens

Synonyms: AQP-6, AQP2L, Aquaporin-2-like, Aquaporin-6, KID, ...
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High impact information on AQP6

  • Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13 [1].
  • PCR analysis of a human/rodent somatic hybrid panel localized the hKID gene to chromosome 12 [2].
  • Expression of hKID cRNA in Xenopus oocytes did not increase glycerol or urea permeability, but increased osmotic water permeability from (2.8 +/- 0.5) x 10(-4) to (7.4 +/- 0.7) x 10(-4) cm/s (10 degrees C) in a mercurial-sensitive manner [2].
  • Sequence comparison of hKID cDNA with a cloned 21-kb genomic DNA indicated three introns (lengths 0.7, 0.25, and 0.4 kb) separating four exons with boundaries at amino acids 121, 174, and 201 [2].
  • A 1.8-kb cDNA clone (designed hKID, gene symbol AQP2L) with homology to the aquaporins was isolated from a human kidney cDNA library [2].

Biological context of AQP6

  • The intracellular distribution indicates that AQP6 has a function distinct from trans-epithelial water movement [3].

Anatomical context of AQP6

  • AQP6 is localized intracellular vesicles in the kidney collecting duct cells [4].
  • Presence or absence at the plasma membrane of AQP6 constructs was confirmed by electrophysiological methods [3].
  • BACKGROUND INFORMATION: Most AQPs (aquaporins) function at the plasma membrane, however AQP6 is exclusively localized to membranes of intracellular vesicles in acid-secreting type-A intercalated cells of renal collecting ducts [3].

Associations of AQP6 with chemical compounds


Analytical, diagnostic and therapeutic context of AQP6


  1. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Ma, T., Yang, B., Umenishi, F., Verkman, A.S. Genomics (1997) [Pubmed]
  2. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. Ma, T., Yang, B., Kuo, W.L., Verkman, A.S. Genomics (1996) [Pubmed]
  3. Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells. Beitz, E., Liu, K., Ikeda, M., Guggino, W.B., Agre, P., Yasui, M. Biol. Cell (2006) [Pubmed]
  4. Aquaporins: water channel proteins of the cell membrane. Takata, K., Matsuzaki, T., Tajika, Y. Progress in histochemistry and cytochemistry. (2004) [Pubmed]
  5. Aquaporin 6 is permeable to glycerol and urea. Holm, L.M., Klaerke, D.A., Zeuthen, T. Pflugers Arch. (2004) [Pubmed]
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