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Gene Review

Cyp6a9  -  Cytochrome P450-6a9

Drosophila melanogaster

Synonyms: 6a9, CG10246, CYP6A9, CYPVIA9, Cyt-P450-rAF4, ...
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High impact information on Cyp6a9

  • Waters and colleagues recently suggested [Waters, L. C., Zelhof, A. C., Shaw, B. J. & Ch'ang, L.-Y. (1992) Proc. Natl. Acad. Sci. USA 89, 4855-4859] that an insertion of a long terminal repeat of transposable element 17.6 into the 3' untranslated region of a P450 gene leads to susceptibility to the insecticide DDT in Drosophila melanogaster [1].
  • Immunoblot analyses of mature and regressed corpora lutea indicated a parallel expression of Ad4BP and side-chain cleavage P-450, and both proteins significantly decreased in the regressed tissues [2].
  • Ad4BP, a zinc finger DNA-binding protein, was identified as a transcription factor regulating steroidogenic P-450 genes in a cAMP-dependent manner [2].
  • P450-dependent bioactivation of Tris-BP [3].
  • Formation of 2-bromoacrolein (2BA) from tris(2,3-dibromopropyl)phosphate (Tris-BP) by cytochrome P450 (cyt. P450) activity is most likely responsible for the high mutagenicity of Tris-BP for bacteria in vitro when rat liver microsomes are used for metabolic activation [3].

Biological context of Cyp6a9


Associations of Cyp6a9 with chemical compounds

  • The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M [6].
  • Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity [6].

Other interactions of Cyp6a9

  • In between them another Cyp gene is present which is more related to Cyp6a9 than to Cyp6a8 [4].

Analytical, diagnostic and therapeutic context of Cyp6a9

  • In the current study, a degenerate polymerase chain reaction (PCR) primer was targeted to the highly conserved region of P450 genes that encodes the heme-binding decapeptide [7].


  1. Noninvolvement of the long terminal repeat of transposable element 17.6 in insecticide resistance in Drosophila. Delpuech, J.M., Aquadro, C.F., Roush, R.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Morohashi, K., Iida, H., Nomura, M., Hatano, O., Honda, S., Tsukiyama, T., Niwa, O., Hara, T., Takakusu, A., Shibata, Y. Mol. Endocrinol. (1994) [Pubmed]
  3. Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution. van Beerendonk, G.J., Nivard, M.J., Vogel, E.W., Nelson, S.D., Meerman, J.H. Carcinogenesis (1994) [Pubmed]
  4. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra, S., Dombrowski, S.M., Waters, L.C., Ganguly, R. Gene (1996) [Pubmed]
  5. Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera:papilionidae). Hung, C.F., Berenbaum, M.R., Schuler, M.A. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  6. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh, D.P., Mitchell, M.J., Crooks, J.R., Smith, S.L. Experientia (1992) [Pubmed]
  7. Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha,25 dihydroxy-D3 24-hydroxylase. Danielson, P.B., Fogleman, J.C. Insect Biochem. Mol. Biol. (1997) [Pubmed]
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