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Gene Review

Cyp6a8  -  Cytochrome P450-6a8

Drosophila melanogaster

Synonyms: 6a8, CG10248, CYP6A8, CYPVIA8, Cyt-P450-rAF5, ...
 
 
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Disease relevance of Cyp6a8

  • Heterologous expression of the CYP6A2 protein in lepidopteran cells infected with a Cyp6a2-recombinant baculovirus was observed by Western blotting of cell lysates and by spectral characterization of the reduced-CO complex of the P450 [1].
 

High impact information on Cyp6a8

 

Biological context of Cyp6a8

  • These results suggest that -11/-761 Cyp6a8 DNA of the 91-R strain can respond to the active repressor present in the hybrid genome and further support our previous findings that overexpression of Cyp6a8 is a result of mutation of a repressor gene rather than mutation of the cis-regulatory sequences [5].
  • Cyp6a8 has two introns of which intron II is similar to the introns of other insect CYP genes with respect to its length and position [5].
  • Analysis of Cyp6a8 upstream DNA of the overproducer 91-R strain showed that DNA sequences between -199 and -761 bp are required for the highest constitutive and barbital-induced expression of Cyp6a8 [5].
  • In the genome, Cyp6a8 and Cyp6a9 genes are closely clustered within 4 kb and map at region 51C of the second chromosome [4].
  • It is also in-frame with the CYP6A8 open reading frame [5].
 

Associations of Cyp6a8 with chemical compounds

 

Other interactions of Cyp6a8

  • In between them another Cyp gene is present which is more related to Cyp6a9 than to Cyp6a8 [4].
 

Analytical, diagnostic and therapeutic context of Cyp6a8

References

  1. The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. Dunkov, B.C., Guzov, V.M., Mocelin, G., Shotkoski, F., Brun, A., Amichot, M., Ffrench-Constant, R.H., Feyereisen, R. DNA Cell Biol. (1997) [Pubmed]
  2. Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture. Bhaskara, S., Dean, E.D., Lam, V., Ganguly, R. Gene (2006) [Pubmed]
  3. Factors on the third chromosome affect the level of cyp6a2 and cyp6a8 expression in Drosophila melanogaster. Maitra, S., Dombrowski, S.M., Basu, M., Raustol, O., Waters, L.C., Ganguly, R. Gene (2000) [Pubmed]
  4. Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster. Maitra, S., Dombrowski, S.M., Waters, L.C., Ganguly, R. Gene (1996) [Pubmed]
  5. Cyp6a8 of Drosophila melanogaster: gene structure, and sequence and functional analysis of the upstream DNA. Maitra, S., Price, C., Ganguly, R. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  6. Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila. Le Goff, G., Boundy, S., Daborn, P.J., Yen, J.L., Sofer, L., Lind, R., Sabourault, C., Madi-Ravazzi, L., ffrench-Constant, R.H. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  7. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. Helvig, C., Tijet, N., Feyereisen, R., Walker, F.A., Restifo, L.L. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  8. Expression and activity of a house-fly cytochrome P450, CYP6D1, in Drosophila melanogaster. Korytko, P.J., MacLntyre, R.J., Scott, J.G. Insect Mol. Biol. (2000) [Pubmed]
  9. cDNA and deduced protein sequence of CYP6D1: the putative gene for a cytochrome P450 responsible for pyrethroid resistance in house fly. Tomita, T., Scott, J.G. Insect Biochem. Mol. Biol. (1995) [Pubmed]
 
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