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Gene Review

Tbxas1  -  thromboxane A synthase 1, platelet

Rattus norvegicus

Synonyms: Cyp5, Cyp5a1, Cytochrome P450 5A1, TXA synthase, TXS, ...
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Disease relevance of Tbxas1


High impact information on Tbxas1


Biological context of Tbxas1


Anatomical context of Tbxas1


Associations of Tbxas1 with chemical compounds

  • 1. The thromboxane A2 synthase (TXS) inhibitory activity and the thromboxane A2 (TP)-receptor blocking action of ZD1542 (4(Z)-6-[2S,4S,5R)-2-[1-methyl-1-(2-nitro-4-tolyloxy)ethyl]-4-(3- pyridyl)-1,3-dioxan-5-yl]hex-4-enoic acid) has been evaluated in vitro on platelets and whole blood from a range of species including man [6].
  • In contrast, the thromboxane A synthase inhibitor, dazoxiben, only partially improved abnormal acetylcholine-induced relaxations in aorta from SHR [9].


  1. Correction of ischaemic brain acidosis with SQ29,548/1-benzylimidazole. Pettigrew, L.C., Hazle, J.D., Gutierrez, G., Smith, C.D., Ogletree, M.L. Neurol. Res. (1992) [Pubmed]
  2. The role of prostaglandin and thromboxane synthesis by the glomeruli in the development of acute renal failure. Chatziantoniou, C., Papanikolaou, N. Eicosanoids (1989) [Pubmed]
  3. Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2. Ikeda, Y., Sugawara, A., Taniyama, Y., Uruno, A., Igarashi, K., Arima, S., Ito, S., Takeuchi, K. J. Biol. Chem. (2000) [Pubmed]
  4. Immunohistochemical localization of thromboxane receptor and thromboxane synthase in rat testis. Takahashi, N., Takeuchi, K., Abe, T., Murakami, K., Yamaguchi, M., Abe, K. Endocrinology (1995) [Pubmed]
  5. Selective impairment of endothelium-dependent relaxations by prostaglandin endoperoxide. Tesfamariam, B. J. Hypertens. (1994) [Pubmed]
  6. ZD1542, a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. Brownlie, R.P., Brownrigg, N.J., Butcher, H.M., Garcia, R., Jessup, R., Lee, V.J., Tunstall, S., Wayne, M.G. Br. J. Pharmacol. (1993) [Pubmed]
  7. Assignment of rat thromboxane synthase gene (Tbxas) to chromosome 4q21-->q22 by fluorescence in situ hybridization. Takeuchi, K., Tsutsumi, E., Abe, T., Takahashi, N., Kato, T., Taniyama, Y., Ikeda, Y., Abe, K. Cytogenet. Cell Genet. (1997) [Pubmed]
  8. Anti-endotoxic shock effects of cyproheptadine in rats. Wang, L., Zhang, Q., Hu, X., Lun, N., Wang, B., Zhu, F. Chin. Med. J. (2002) [Pubmed]
  9. Dissociation of endothelial cell dysfunction and blood pressure in SHR. Tesfamariam, B., Ogletree, M.L. Am. J. Physiol. (1995) [Pubmed]
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