Gene Review:
Tbxas1 - thromboxane A synthase 1, platelet
Mus musculus
Synonyms:
CYP5, CYP5A1, Cyp5, Cyp5a1, Cytochrome P450 5A1, ...
- TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Yu, I.S., Lin, S.R., Huang, C.C., Tseng, H.Y., Huang, P.H., Shi, G.Y., Wu, H.L., Tang, C.L., Chu, P.H., Wang, L.H., Wu, K.K., Lin, S.W. Blood (2004)
- Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates. Houghton, P.J., Rahman, A., Will, C.L., Dolnick, B.J., Houghton, J.A. Cancer Res. (1992)
- Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells. Shaw, D., Berger, F.G., Spencer, H.T. Hum. Gene Ther. (2001)
- Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine. Cao, S., McGuire, J.J., Rustum, Y.M. Clin. Cancer Res. (1999)
- Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression. Powell, C.M., Rudge, T.L., Zhu, Q., Johnson, L.F., Hansen, U. EMBO J. (2000)
- p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. Deveaux, S., Cohen-Kaminsky, S., Shivdasani, R.A., Andrews, N.C., Filipe, A., Kuzniak, I., Orkin, S.H., Roméo, P.H., Mignotte, V. EMBO J. (1997)
- Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression. Nussbaum, R.L., Walmsley, R.M., Lesko, J.G., Airhart, S.D., Ledbetter, D.H. Am. J. Hum. Genet. (1985)
- Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase. Jones, T.R., Varney, M.D., Webber, S.E., Lewis, K.K., Marzoni, G.P., Palmer, C.L., Kathardekar, V., Welsh, K.M., Webber, S., Matthews, D.A., Appelt, K., Smith, W.W., Janson, C.A., Villafranca, J.E., Bacquet, R.J., Howland, E.F., Booth, C.L., Herrmann, S.M., Ward, R.W., White, J., Moomaw, E.W., Bartlett, C.A., Morse, C.A. J. Med. Chem. (1996)
- Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. Jones, T.R., Webber, S.E., Varney, M.D., Reddy, M.R., Lewis, K.K., Kathardekar, V., Mazdiyasni, H., Deal, J., Nguyen, D., Welsh, K.M., Webber, S., Johnston, A., Matthews, D.A., Smith, W.W., Janson, C.A., Bacquet, R.J., Howland, E.F., Booth, C.L., Herrmann, S.M., Ward, R.W., White, J., Bartlett, C.A., Morse, C.A. J. Med. Chem. (1997)
- Gene expression in cells infected with gammaherpesvirus saimiri: properties of transcripts from two immediate-early genes. Nicholas, J., Smith, E.P., Coles, L., Honess, R. Virology (1990)
- The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo. Ehrnrooth, E., von der Maase, H., Sørensen, B.S., Poulsen, J.H., Horsman, M.R. Int. J. Radiat. Biol. (1999)
- Genomic organization, chromosomal localization, and expression of the murine thromboxane synthase gene. Zhang, L., Xiao, H., Schultz, R.A., Shen, R.F. Genomics (1997)
- Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. Kuwamoto, S., Inoue, H., Tone, Y., Izumi, Y., Tanabe, T. FEBS Lett. (1997)
- Multiple factors regulating the expression of human thromboxane synthase gene. Lee, K.D., Baek, S.J., Shen, R.F. Biochem. J. (1996)
- Molecular cloning and expression of murine thromboxane synthase. Zhang, L., Chase, M.B., Shen, R.F. Biochem. Biophys. Res. Commun. (1993)
- Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. van der Wilt, C.L., Backus, H.H., Smid, K., Comijn, L., Veerman, G., Wouters, D., Voorn, D.A., Priest, D.G., Bunni, M.A., Mitchell, F., Jackman, A.L., Jansen, G., Peters, G.J. Cancer Res. (2001)
- ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Jackman, A.L., Taylor, G.A., Gibson, W., Kimbell, R., Brown, M., Calvert, A.H., Judson, I.R., Hughes, L.R. Cancer Res. (1991)
- Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. Rafi, I., Boddy, A.V., Calvete, J.A., Taylor, G.A., Newell, D.R., Bailey, N.P., Lind, M.J., Green, M., Hines, J., Johnstone, A., Clendeninn, N., Calvert, A.H. J. Clin. Oncol. (1998)
- Analysis of thymidylate synthase gene amplification and of mRNA levels in the cell cycle. Imam, A.M., Crossley, P.H., Jackman, A.L., Little, P.F. J. Biol. Chem. (1987)
- Activin A and retinoic acid synergize in cyclooxygenase-1 and thromboxane synthase induction during differentiation of J774.1 macrophages. Nüsing, R.M., Mohr, S., Ullrich, V. Eur. J. Biochem. (1995)
- Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues. Welsh, S.J., Titley, J., Brunton, L., Valenti, M., Monaghan, P., Jackman, A.L., Aherne, G.W. Clin. Cancer Res. (2000)
- Schedule-dependent synergism of vinorelbine and 5-fluorouracil/UFT against non-small cell lung cancer. Matsumoto, S., Igishi, T., Hashimoto, K., Kodani, M., Shigeoka, Y., Nakanishi, H., Touge, H., Kurai, J., Makino, H., Takeda, K., Yasuda, K., Hitsuda, Y., Shimizu, E. Int. J. Oncol. (2004)
- Experimental studies on potentiation of the antitumor activity of 5-fluorouracil with 3'-azido-3'-deoxythymidine for the gastric cancer cell line MKN28 in vivo. Yasuda, C., Kato, M., Kuroda, D., Ohyanagi, H. Jpn. J. Cancer Res. (1997)
- S-1, an oral fluoropyrimidine, enhances radiation response of DLD-1/FU human colon cancer xenografts resistant to 5-FU. Nakata, E., Fukushima, M., Takai, Y., Nemoto, K., Ogawa, Y., Nomiya, T., Nakamura, Y., Milas, L., Yamada, S. Oncol. Rep. (2006)