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Gene Review

Dg  -  Dystroglycan

Drosophila melanogaster

Synonyms: CG18250, CT41273, DG, DmDG, Dmel\CG18250, ...
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Disease relevance of Dg


High impact information on Dg


Biological context of Dg

  • We suggest that the interaction of Pcan and Dg at the basal side of the epithelium promotes basal membrane differentiation and is required for maintenance of cell polarity in the FCE [4].
  • These data suggest that the primary function of Dystroglycan in oogenesis is to organize cellular polarity; and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics [1].
  • In Dg, the isolated G-type sequence carries a 420-bp insertion in the promoter region, which is probably responsible for inactivation [5].

Anatomical context of Dg

  • In epithelial cells, reduced expression of Dg is associated with increased invasiveness of cancer cells [4].
  • Dystroglycan (Dg) is a widely expressed extracellular matrix (ECM) receptor required for muscle viability, synaptogenesis, basementmembrane formation and epithelial development [4].
  • As an integral component of the Dystrophin-associated glycoprotein complex, Dg plays a central role in linking the ECM and the cytoskeleton [4].
  • Our data indicate that Dystroglycan links EGFR-induced repression of the anterior follicle cell fate and anterior-posterior polarity formation in the oocyte [3].

Other interactions of Dg

  • Furthermore, Dg depends on Pcan but not on Laminin A for its localization in the basal-cell membrane, and the two proteins bind in vitro [4].
  • Finally, we describe two examples of how Dg promotes the differentiation of the basal membrane domain: (1) by recruiting/anchoring the cytoplasmic protein Dystrophin; and (2) by excluding the transmembrane protein Neurexin [4].


  1. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Deng, W.M., Schneider, M., Frock, R., Castillejo-Lopez, C., Gaman, E.A., Baumgartner, S., Ruohola-Baker, H. Development (2003) [Pubmed]
  2. Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. Shcherbata, H.R., Yatsenko, A.S., Patterson, L., Sood, V.D., Nudel, U., Yaffe, D., Baker, D., Ruohola-Baker, H. EMBO J. (2007) [Pubmed]
  3. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Poulton, J.S., Deng, W.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Schneider, M., Khalil, A.A., Poulton, J., Castillejo-Lopez, C., Egger-Adam, D., Wodarz, A., Deng, W.M., Baumgartner, S. Development (2006) [Pubmed]
  5. Structure and expression of clustered P element homologues in Drosophila subobscura and Drosophila guanche. Miller, W.J., Paricio, N., Hagemann, S., Martínez-Sebastián, M.J., Pinsker, W., de Frutos, R. Gene (1995) [Pubmed]
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