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FBN1  -  fibrillin 1

Gallus gallus

 
 
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High impact information on FBN1

  • These morphological traits together with the distribution of vimentin, the ES/130 protein, and the JB3/fibrillin-associated antigen suggested a localized transformation of some epicardial mesothelial cells into mesenchyme [1].
  • Furthermore, we immunolocated, in the proepicardial mesothelium, three proteins specifically expressed during the endothelial-mesenchymal transition of the endocardial cushions, namely the JB3/fibrillin-associated antigen, the ES/130 protein and the smooth muscle cell alpha-actin [1].
  • Cross-linked elastin can be found in association with several microfibril-associated proteins including fibrillin-1, fibrillin-2 and fibulin-1 suggesting that these proteins contribute to elastic fiber assembly, structure or function [2].
  • Prior to stage 21 the embryonic heart lacks elastin but exhibits a matrix scaffold of fibrillin and emilin associated with the endocardium and the developing cardiac jelly [3].
  • The epicardium constitutes an additional region of elastic matrix deposition during these later stages and contains elastic, fibrillin, and collagen type VI.(ABSTRACT TRUNCATED AT 400 WORDS)[3]
 

Anatomical context of FBN1

 

Analytical, diagnostic and therapeutic context of FBN1

  • Using homologous PCR we amplified and cloned a 407 nt fragment of chicken cDNA that appears to code for an orthologue of FBN-1 [7].
  • Using primers specific for FBN-1 and FBN-2 in RT-PCR reactions we confirm the presence of fib- 1 and fib-2 mRNA in early embryonic stages [7].
  • The distributions of elastin and fibrillin were studied immunohistochemically in whole-mount preparations using confocal laser microscopy [8].

References

  1. The origin of the subepicardial mesenchyme in the avian embryo: an immunohistochemical and quail-chick chimera study. Pérez-Pomares, J.M., Macías, D., García-Garrido, L., Muñoz-Chápuli, R. Dev. Biol. (1998) [Pubmed]
  2. Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development. Visconti, R.P., Barth, J.L., Keeley, F.W., Little, C.D. Matrix Biol. (2003) [Pubmed]
  3. Elastic extracellular matrix of the embryonic chick heart: an immunohistological study using laser confocal microscopy. Hurle, J.M., Kitten, G.T., Sakai, L.Y., Volpin, D., Solursh, M. Dev. Dyn. (1994) [Pubmed]
  4. Partial cloning and sequencing of chick fibrillin-1 cDNA. Zhou, G., Price, C.E., Rosenquist, T.H., Gadson, P.F., Godfrey, M. In Vitro Cell. Dev. Biol. Anim. (2000) [Pubmed]
  5. Fibrillin delineates the primary axis of the early avian embryo. Gallagher, B.C., Sakai, L.Y., Little, C.D. Dev. Dyn. (1993) [Pubmed]
  6. Immunohistological and ultrastructural study of the developing tendons of the avian foot. Ros, M.A., Rivero, F.B., Hinchliffe, J.R., Hurle, J.M. Anat. Embryol. (1995) [Pubmed]
  7. Distribution of fibrillin I in extracellular matrix and epithelia during early development of avian embryos. Burke, R.D., Wang, D., Mark, S., Martens, G. Anat. Embryol. (2000) [Pubmed]
  8. Elastin exhibits a distinctive temporal and spatial pattern of distribution in the developing chick limb in association with the establishment of the cartilaginous skeleton. Hurle, J.M., Corson, G., Daniels, K., Reiter, R.S., Sakai, L.Y., Solursh, M. J. Cell. Sci. (1994) [Pubmed]
 
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