High impact information on TUBA8

• A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine [1].
• These data confirm the results obtained with the neuronal cell line and emphasize the importance of the three promoter elements for the transferrin gene-specific expression in the central nervous system compared with only two elements required for liver- and testis-specific expression [2].
• H1t is a testis-specific H1 variant found in pachytene spermatocytes and round spermatids of mammals [3].
• Moreover, as HINTW is distinctly different from its homolog on the Z chromosome (HINTZ), is a candidate gene in avian sex determination, and evolves rapidly under positive selection, it shows several common features to ampliconic and testis-specific genes on the mammalian Y chromosome [4].
• A comparison of the globular domain sequences of the somatic H1d and testis-specific H1t revealed a single substitution of lysine 52 in H1d to glutamine 54 in H1t, which is one of the three crucial residues within the second DNA binding site [5].

Biological context of TUBA8

• A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y [6].
• Expression of lactate dehydrogenases A and B during chicken spermatogenesis: characterization of testis specific transcripts [7].
• These testis specific transcripts and the mRNA of mammalian LDH-C show several properties in common, such as temporal correlation of expression, mRNA stability, and repression of premature translation [7].
• A set of testis-specific novel genes collected from a collection of Korean Native Chicken ESTs [8].

Anatomical context of TUBA8

• Our results suggest that the use of a testis-specific promoter would result in the incorporation of somatic promoter sequences into the 5' UTR of the testis message [9].
• The testis-specific histone Hlt (from rat) did not have an H1o-like structure and it appears that H1o does not occur in spermatocytes in any form [10].

Associations of TUBA8 with chemical compounds

• Cloning of chicken lanosterol 14alpha-demethylase (CYP51) cDNA: Discovery of a testis-specific CYP51 transcript [11].

Other interactions of TUBA8

• Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals [12].
• While mammals and columbid birds express the testis specific LDH-C gene in meiotic and postmeiotic cells, several LDH-B testis specific transcripts were detected in the corresponding cells during chicken spermatogenesis [7].

Analytical, diagnostic and therapeutic context of TUBA8

• Unlike the mammals, no evidence for a single domain, testis specific form of ACE was found in the chicken testis by either Northern blot or enzyme assay [12].

References